Phytochemical Analysis and Biological Evaluation of Carob Leaf (Ceratonia siliqua L.) Crude Extracts Using NMR and Mass Spectroscopic Techniques

Autor: Themistoklis Venianakis, Nikolaos Parisis, Atalanti Christou, Vlasios Goulas, Nikolaos Nikoloudakis, George Botsaris, Tjaša Goričan, Simona Golič Grdadolnik, Andreas G. Tzakos, Ioannis P. Gerothanassis

Publikováno v: Molecules, Vol 29, Iss 22, p 5273 (2024)

Carob leaves have gained attention for their bioactive properties and traditional medicinal uses, including as treatment for diabetes, digestive disorders, and microbial infections. The aim of this study was to explore the phytochemical composition o

Externí odkaz: https://doaj.org/article/92c5215174b6459cae32f0943eaebf9e

Evaluation of Selected CYP51A1 Polymorphisms in View of Interactions with Substrate and Redox Partner

Autor: Tadeja Režen, Iza Ogris, Marko Sever, Franci Merzel, Simona Golic Grdadolnik, Damjana Rozman

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that

Externí odkaz: https://doaj.org/article/1c2d9dfa2aab4a0787f4b54c53cf2729

Polymorphisms of CYP51A1 from cholesterol synthesis: associations with birth weight and maternal lipid levels and impact on CYP51 protein structure.

Autor: Monika Lewińska, Urska Zelenko, Franci Merzel, Simona Golic Grdadolnik, Jeffrey C Murray, Damjana Rozman

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82554 (2013)

We investigated the housekeeping cytochrome P450 CYP51A1 encoding lanosterol 14α-demethylase from cholesterol synthesis that was so far not directly linked to human disorders. By direct sequencing of CYP51A1 in 188 women with spontaneous preterm del

Externí odkaz: https://doaj.org/article/cb474d49852545a1865a31c6ff35af1e

Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions

Autor: Doriano Lamba, Sonia Covaceuszach, Franci Merzel, Alberto Cassetta, Francesca Paoletti, Simona Golic Grdadolnik, Iza Ogris, Jože Grdadolnik

Publikováno v: Computational and Structural Biotechnology Journal 19 (2021): 2938–2949. doi:10.1016/j.csbj.2021.05.009
info:cnr-pdr/source/autori:Paoletti F.; Merzel F.; Cassetta A.; Ogris I.; Covaceuszach S.; Grdadolnik J.; Lamba D.; Golic Grdadolnik S./titolo:Endogenous modulators of neurotrophin signaling: Landscape of the transient ATP-NGF interactions/doi:10.1016%2Fj.csbj.2021.05.009/rivista:Computational and Structural Biotechnology Journal/anno:2021/pagina_da:2938/pagina_a:2949/intervallo_pagine:2938–2949/volume:19
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2938-2949 (2021)
Computational and Structural Biotechnology Journal

Graphical abstract
Highlights • High-resolution solution NMR structure of rhNGF has been determined. • Quinary interactions characterize ATP binding to rhNGF. • SPR, ITC and STD-NMR reveal ATP binding to rhNGF with mM affinity. • NMR and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad8b1ec3a685ab9524b7c239670f5be
https://doi.org/10.1016/j.csbj.2021.05.009

Drug Incorporation in the Drug Delivery System of Micelles

Autor: Evangelia Soumelidou, Simona Golic Grdadolnik, Thomas Mavromoustakos

Publikováno v: Supramolecules in Drug Discovery and Drug Delivery ISBN: 9781071609194

Micelles is a system frequently used for drug delivery. Drugs are incorporated and protected in micelles before being delivered. Nuclear magnetic resonance is a suitable technique to detect the localization and incorporation of drugs into the micelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06702a51088c3cb3f35775c9c9be2678
https://doi.org/10.1007/978-1-0716-0920-0_8