Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Simona Ghenea"'
Autor:
Simona Ghenea, Marioara Chiritoiu, Robi Tacutu, Antonio Miranda-Vizuete, Stefana Maria Petrescu
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010069 (2022)
EDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many p
Externí odkaz:
https://doaj.org/article/4faf25871f044cfb9e78bf3cecbbe3bd
Autor:
Lavinia Liliana Ruta, Ya-Fen Lin, Ralph Kissen, Ioana Nicolau, Aurora Daniela Neagoe, Simona Ghenea, Atle M Bones, Ileana Cornelia Farcasanu
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178393 (2017)
In this study we engineered yeast cells armed for heavy metal accumulation by targeting plant metallothioneins to the inner face of the yeast plasma membrane. Metallothioneins (MTs) are cysteine-rich proteins involved in the buffering of excess metal
Externí odkaz:
https://doaj.org/article/b40b3d630e484063828706d1cfa544bf
Autor:
Marioara B Marin, Simona Ghenea, Laurentiu N Spiridon, Gabriela N Chiritoiu, Andrei-Jose Petrescu, Stefana-Maria Petrescu
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42998 (2012)
EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing
Externí odkaz:
https://doaj.org/article/102caa9e862244ed938780359f9a13ac
Autor:
Daniela Cioaca, Simona Ghenea, Laurentiu N Spiridon, Marioara Marin, Andrei-Jose Petrescu, Stefana M Petrescu
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19979 (2011)
The N-glycans of membrane glycoproteins are mainly exposed to the extracellular space. Human tyrosinase is a transmembrane glycoprotein with six or seven bulky N-glycans exposed towards the lumen of subcellular organelles. The central active site reg
Externí odkaz:
https://doaj.org/article/747e8b81fd7b43c0b6e18b6e50aada05
Autor:
Dmitri Toren, Simona Ghenea, Vimbai Netsai Charity Samukange, Gabriela Bunu, Robi Tacutu, Ioan Valentin Matei
Publikováno v:
Aging (Albany NY)
Genetic manipulations can ameliorate the aging process and extend the lifespan of model organisms. The aim of this research was to identify novel genetic interventions that promote both lifespan and healthspan, by combining the effects of multiple lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d7d16667e2592f4749338c1c373a3b
http://europepmc.org/articles/PMC8457566
http://europepmc.org/articles/PMC8457566
Age-related pathologies are so widely presented in old age that in most cases they are hardly distinguishable at the molecular level from the so-called ‘‘normal’’ aging. Both aging and age-related diseases are characterized by a wide range of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::790923d95554c9afaa5ea9b1dbd4927b
https://doi.org/10.1101/2022.11.01.514657
https://doi.org/10.1101/2022.11.01.514657
Autor:
Simona Ghenea, Marioara Chiritoiu, Robi Tacutu, Antonio Miranda-Vizuete, Stefana Maria Petrescu
Publikováno v:
PLoS genetics. 18(2)
EDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a37b5a77f018b98fce0cbb7fb15bd8
https://pubmed.ncbi.nlm.nih.gov/35192599
https://pubmed.ncbi.nlm.nih.gov/35192599
Autor:
Petruta R. Alexandru, Gabriela Chiritoiu, Cristian V.A. Munteanu, Marius Surleac, Georgiana Manica, Simona Ghenea, Andrei-Jose Petrescu, Cristian M. Butnaru, Stefana M. Petrescu, Eliza C. Martin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2172, p 2172 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences
Volume 22
Issue 4
EDEM3 recognizes and directs misfolded proteins to the ER-associated protein degradation (ERAD) process. EDEM3 was predicted to act as lectin or as a mannosidase because of its homology with the GH47 catalytic domain of the Man1B1, but the contributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb40f9045b86e10f846967c051cb6d28
https://pubmed.ncbi.nlm.nih.gov/33671632
https://pubmed.ncbi.nlm.nih.gov/33671632
Autor:
Marioara Chirițoiu, Simona Ghenea, Gabriela N. Chirițoiu, Andrei-Jose Petrescu, Stefana M. Petrescu, Cristian V.A. Munteanu
Publikováno v:
Molecular & Cellular Proteomics : MCP
Various pathologies result from disruptions to or stress of endoplasmic reticulum (ER) homeostasis, such as Parkinson's disease and most neurodegenerative illnesses, diabetes, pulmonary fibrosis, viral infections, and cancers. A critical process in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00203f941821c97c93215890a483b51
https://pubmed.ncbi.nlm.nih.gov/34332121
https://pubmed.ncbi.nlm.nih.gov/34332121
Autor:
Pedro Romero, Philippe O. Gannon, Cristian V.A. Munteanu, Camilla Jandus, Stefana M. Petrescu, Gabriela Chiritoiu, Simona Ghenea
Publikováno v:
ELECTROPHORESIS. 37:1448-1460
The degradation process of the antigens specific to MHC-I presentation depends mainly on the proteasomal proteases in the cytosol. However, since many antigens are glycoproteins, including tumor antigens or viruses envelope proteins, their glycosylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::360c6b742459f16c3053a3dd19d87213
https://doi.org/10.1002/elps.201500449
https://doi.org/10.1002/elps.201500449