Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Simona Frateschi"'
1
Akademický článek
Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity
Autor: Elodie Ehret, Sévan Stroh, Muriel Auberson, Frédérique Ino, Yannick Jäger, Marc Maillard, Roman Szabo, Thomas H. Bugge, Simona Frateschi, Edith Hummler
Publikováno v: Cells, Vol 12, Iss 19, p 2342 (2023)
The serine proteases CAP1/Prss8 and CAP3/St14 are identified as ENaC channel-activating proteases in vitro, highly suggesting that they are required for proteolytic activation of ENaC in vivo. The present study tested whether CAP3/St14 is relevant fo
Externí odkaz: https://doaj.org/article/c6b5a932c8c94f73bb776dd9d47fb1a1
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2
Akademický článek
Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway
Autor: Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger, Ivan Gautschi, Roman Szabo, Thomas H. Bugge, Lotte K. Vogel, Edith Hummler, Simona Frateschi
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 12, p 6745 (2022)
The serine protease prostasin (CAP1/Prss8, channel-activating protease-1) is a confirmed in vitro and in vivo activator of the epithelial sodium channel ENaC. To test whether proteolytic activity or CAP1/Prss8 abundance itself are required for ENaC a
Externí odkaz: https://doaj.org/article/1cc4224e73f845d493dd991c918734ff
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3
Akademický článek
Lack of Renal Tubular Glucocorticoid Receptor Decreases the Thiazide-Sensitive Na+/Cl– Cotransporter NCC and Transiently Affects Sodium Handling
Autor: Jérémie Canonica, Simona Frateschi, Emilie Boscardin, Anna Ebering, Chloé Sergi, Yannick Jäger, Thibaud Peyrollaz, Anne-Marie Mérillat, Marc Maillard, Petra Klusonova, Alex Odermatt, Robert Koesters, Anne Debonneville, Olivier Staub, Sophia N. Verouti, Edith Hummler
Publikováno v: Frontiers in Physiology, Vol 10 (2019)
Chronic glucocorticoid infusion impairs NCC activity and induces a non-dipping profile in mice, suggesting that glucocorticoids are essential for daily blood pressure variations. In this paper, we studied mice lacking the renal tubular glucocorticoid
Externí odkaz: https://doaj.org/article/94cec7ac22974ea5b7e7c6c28a09bae4
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4
Akademický článek
The channel-activating protease CAP1/Prss8 is required for placental labyrinth maturation.
Autor: Edith Hummler, Aline Dousse, Audrey Rieder, Jean-Christophe Stehle, Isabelle Rubera, Maria-Chiara Osterheld, Friedrich Beermann, Simona Frateschi, Roch-Philippe Charles
Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55796 (2013)
The serine protease CAP1/Prss8 is crucial for skin barrier function, lung alveolar fluid clearance and has been unveiled as diagnostic marker for specific cancer types. Here, we show that a constitutive knockout of CAP1/Prss8 leads to embryonic letha
Externí odkaz: https://doaj.org/article/9a580cb873b145eba6aa52e64ed5ac1b
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5
Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice
Autor: Edith Hummler, Emilie Boscardin, Simona Frateschi, Sophia N. Verouti
Publikováno v: CURRENT OPINION IN PHARMACOLOGY
The activity of the thiazide-sensitive Na(+)/Cl(-) cotransporter (NCC) and of the amiloride-sensitive epithelial Na(+) channel (ENaC) is pivotal for blood pressure regulation. NCC is responsible for Na(+) reabsorption in the distal convoluted tubule
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a3c170f3d178d9caede5d2565579a
https://doi.org/10.1016/j.coph.2014.12.012
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6
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19
Autor: Edith Hummler, Emilie Boscardin, Simona Frateschi, Omar Alijevic, Stephan Kellenberger
Publikováno v: British Journal of Pharmacology
British Journal of Pharmacology, vol. 173, no. 18, pp. 2671-2701
Acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC) are both members of the ENaC/degenerin family of amiloride-sensitive Na(+) channels. ASICs act as proton sensors in the nervous system where they contribute, besides other role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b1b554c7b6c1e7b539a55b95210d67
https://pubmed.ncbi.nlm.nih.gov/27278329
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7
Mutations of the Serine Protease CAP1/Prss8 Lead to Reduced Embryonic Viability, Skin Defects, and Decreased ENaC Activity
Autor: Edith Hummler, Nicole Fowler-Jaeger, Chloé Sergi, Carole Planès, Justyna Iwaszkiewicz, Anna Keppner, Nadia Randrianarison, Sumedha Malsure, Anne-Marie Mérillat, Simona Frateschi
Publikováno v: American Journal of Pathology, vol. 181, no. 2, pp. 605-615
The American journal of pathology
AMERICAN JOURNAL OF PATHOLOGY
CAP1/Prss8 is a membrane-bound serine protease involved in the regulation of several different effectors, such as the epithelial sodium channel ENaC, the protease-activated receptor PAR2, the tight junction proteins, and the profilaggrin polypeptide.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac3987ab693ab3bb118ea3000b07385
https://doi.org/10.1016/j.ajpath.2012.05.007
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9
Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype
Autor: Dominique Loffing-Cueni, Johannes Loffing, Simona Frateschi, Bernard C. Rossier, Robert Koesters, Petra Klusonova, Marc Maillard, Edith Hummler, Chloé Sergi, Jérémie Canonica, Alex Odermatt
Publikováno v: Pflugers Archiv : European journal of physiology, vol. 468, no. 5, pp. 895-908
Aldosterone is the main mineralocorticoid hormone controlling sodium balance, fluid homeostasis, and blood pressure by regulating sodium reabsorption in the aldosterone-sensitive distal nephron (ASDN). Germline loss-of-function mutations of the miner
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::724bc1e66a675014dd603413a737b34d
https://pubmed.ncbi.nlm.nih.gov/26762397
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10
Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit
Autor: Sumedha Malsure, Robert Koesters, Bernard C. Rossier, Dominique Loffing-Cueni, Romain Perrier, Marc Maillard, Mads V. Sorensen, Emilie Boscardin, Simona Frateschi, Johannes Loffing, Edith Hummler, Chloé Sergi
Publikováno v: Perrier, R, Boscardin, E, Malsure, S, Sergi, C, Maillard, M P, Loffing, J, Loffing, D C, Sørensen, M V, Koesters, R, Rossier, B C, Frateschi, S & Hummler, E 2016, ' Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit ', Journal of the American Society of Nephrology, vol. 27, no. 8, pp. 2309-2318 . https://doi.org/10.1681/ASN.2015020154
Journal of the American Society of Nephrology, vol. 27, no. 8, pp. 2309-2318
Systemic pseudohypoaldosteronism type 1 (PHA-1) is a severe salt-losing syndrome caused by loss-of-function mutations of the amiloride-sensitive epithelial sodium channel (ENaC) and characterized by neonatal life-threatening hypovolemia and hyperkale
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd0fca94575752321c3e8161d911141
https://pubmed.ncbi.nlm.nih.gov/26701978
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