Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Simona Federica Spampinato"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/d6f0a9aa876846e69b0ca7d57ff7a501
Autor:
Giorgia Serena Gullotta, Giuseppe Costantino, Maria Angela Sortino, Simona Federica Spampinato
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9144 (2023)
Microglia are the resident immune cells of the central nervous system that guarantee immune surveillance and exert also a modulating role on neuronal synaptic development and function. Upon injury, microglia get activated and modify their morphology
Externí odkaz:
https://doaj.org/article/73cf033ed6044086b15d1934c19908f3
Autor:
Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Pier Luigi Canonico, Maria Angela Sortino
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1174 (2022)
Microglia, together with astrocytes and pericytes, cooperate to ensure blood–brain barrier (BBB) stability, modulating endothelial responses to inflammatory insults. Agonists of the sphingosine 1 phosphate (S1P) receptors, such as siponimod (BAF-31
Externí odkaz:
https://doaj.org/article/ffa787aa74704d229a1bc62c6c310649
Autor:
Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Yasuteru Sano, Takashi Kanda, Maria Angela Sortino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which participate in neuroinflammation. Defects at the blood-brain barrier (BBB) facilitate PBM
Externí odkaz:
https://doaj.org/article/7169283a49624c18a37472c1341d7123
Autor:
Arianna Carolina Rosa, Patrizia Nardini, Silvia Sgambellone, Maura Gurrieri, Simona Federica Spampinato, Alfonso Dell’Accio, Paul L Chazot, Ilona Obara, Wai L Liu, Alessandro Pini
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 184 (2022)
Among the histamine receptors, growing evidence points to the histamine H3 receptor as a pharmacological candidate to counteract the autonomic neuropathy associated with diabetes. The study aimed to evaluate the effect of PF00868087 (also known as ZP
Externí odkaz:
https://doaj.org/article/e499ba4ea6514e01847df64e78640c43
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Glial-neuronal cross-talk has a critical role in the development of neurodegenerative conditions, including Alzheimer’s Disease, where it affects neuronal responses to β-amyloid peptide (Aβ)-induced toxicity. We set out to identify facto
Externí odkaz:
https://doaj.org/article/722c2f62e15647dca9f8e86af5410c9f
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1807 (2021)
Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, a socio-economic burden destined to worsen with increased population aging [...]
Externí odkaz:
https://doaj.org/article/9ec41760f0ef4156b6c9ce2dfa8d6903
Autor:
Simona Federica Spampinato, Valeria Bortolotto, Pier Luigi Canonico, Maria Angela Sortino, Mariagrazia Grilli
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Astrocytes are essential for proper regulation of the central nervous system (CNS). Importantly, these cells are highly secretory in nature. Indeed they can release hundreds of molecules which play pivotal physiological roles in nervous tissues and w
Externí odkaz:
https://doaj.org/article/7592da2b5563494fad29b2efec3dce8a
Autor:
Simona Federica Spampinato, Sara Merlo, Evelina Fagone, Mary Fruciano, Cristina Barbagallo, Takashi Kanda, Yasuteru Sano, Michele Purrello, Carlo Vancheri, Marco Ragusa, Maria Angela Sortino
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
BackgroundThe brain is protected by the blood-brain barrier (BBB), constituted by endothelial cells supported by pericytes and astrocytes. In Alzheimer’s disease a dysregulation of the BBB occurs since the early phases of the disease leading to an
Externí odkaz:
https://doaj.org/article/2ae6a18f2e964304bc73094274d26a68
Autor:
Grazia Ilaria Caruso, Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo, Maria Angela Sortino
Publikováno v:
Biomedicines, Vol 9, Iss 5, p 466 (2021)
Microglia represent a first-line defense in the brain. However, in pathological conditions such as Alzheimer’s disease (AD), a pro-inflammatory switch may occur, leading to loss of protective functions. Using the human microglial cell line HMC3, we
Externí odkaz:
https://doaj.org/article/77258bb773f04f89aff87045f3b129db