Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Simona Ceglia"'
Autor:
Enrico Iaccino, Selena Mimmi, Vincenzo Dattilo, Fabiola Marino, Patrizio Candeloro, Antonio Di Loria, Danilo Marimpietri, Antonio Pisano, Francesco Albano, Eleonora Vecchio, Simona Ceglia, Gaetanina Golino, Antonio Lupia, Giuseppe Fiume, Ileana Quinto, Giuseppe Scala
Publikováno v:
Molecular Cancer, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technology platforms for exosome isolat
Externí odkaz:
https://doaj.org/article/164c43bdb8ef4cbb86b7717c724f6144
Autor:
Giuseppe Fiume, Annarita Scialdone, Francesca Rizzo, Maria Rosaria De Filippo, Carmelo Laudanna, Francesco Albano, Gaetanina Golino, Eleonora Vecchio, Marilena Pontoriero, Selena Mimmi, Simona Ceglia, Antonio Pisano, Enrico Iaccino, Camillo Palmieri, Sergio Paduano, Giuseppe Viglietto, Alessandro Weisz, Giuseppe Scala, Ileana Quinto
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1848 (2016)
The IBTK gene encodes the major protein isoform IBTKα that was recently characterized as substrate receptor of Cul3-dependent E3 ligase, regulating ubiquitination coupled to proteasomal degradation of Pdcd4, an inhibitor of translation. Due to the p
Externí odkaz:
https://doaj.org/article/0d53e43eb0c0439d90b3284caa865dcb
Publikováno v:
bioRxiv
Lymphoid tissue inducer (LTi) cells develop during intrauterine life and rely on developmental programs to initiate the organogenesis of secondary lymphoid organs (SLOs). This evolutionary conserved process endows the fetus with the ability to orches
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff5a877369a254ff151ff9bfe12afe5
https://europepmc.org/articles/PMC10055282/
https://europepmc.org/articles/PMC10055282/
Autor:
Simona Ceglia, Alyssa Berthelette, Kelsey Howley, Yun Li, Nicole K. H. Yiew, Ying Xu, Robert Adrian Brink, Jason G. Cyster, Lora V. Hooper, Gwendalyn J. Randolph, Andrea Reboldi
Publikováno v:
The Journal of Immunology. 208:115.07-115.07
Immunoglobulin A (IgA) secretion by plasma cells (PCs), terminally differentiated B cells residing in the intestinal lamina propria, assures microbiome homeostasis and protects the host against enteric infections. However, whether exposure to diet-de
Autor:
Fiona Raso, Simona Ceglia, Kelsey Howley, Alyssa Berthelette, Andrea Reboldi, Bruno Caetano Trindade, Jagan R. Muppidi
Intestinal B cell responses are critical for the maintenance of gut homeostasis, yet environmental signals that control B cell metabolism and effector function remain poorly characterized. Here, we show that Peyer’s patches germinal center (GC) B c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c6015296f919a9bb2abb5fa85aaa820
https://doi.org/10.1101/2020.11.03.367177
https://doi.org/10.1101/2020.11.03.367177
Autor:
Xuqiu Lei, Khaja Muneeruddin, Ruth Wilson, Simona Ceglia, Fiachra Humphries, Liraz Shmuel-Galia, Katherine A. Fitzgerald, Scott A. Shaffer, JeanMarie Houghton, Doyle V. Ward, Andrea Reboldi, Natália Ketelut-Carneiro, Susanne Pechhold, Sage E. Foley, Beth A. McCormick, Zhaozhao Jiang, Ann Marshak-Rothstein
Publikováno v:
Immunity
Alterations in the cGAS-STING DNA-sensing pathway affect intestinal homeostasis. We sought to delineate the functional role of STING in intestinal inflammation. Increased STING expression was a feature of intestinal inflammation in mice with colitis
Autor:
Kelsey Howley, Jagan R. Muppidi, Andrea Reboldi, Bruno C. Trindade, Alyssa Berthelette, Fiona Raso, Simona Ceglia
Publikováno v:
Immunity. 54:2273-2287.e6
Summary Diets high in cholesterol alter intestinal immunity. Here, we examined how the cholesterol metabolite 25-hydroxycholesterol (25-HC) impacts the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase (CH25H), the enzyme generating
Autor:
Simona Ceglia, Giuseppe Fiume, Antonio Pisano, Enrico Iaccino, Giuseppe Scala, Ileana Quinto, Gaetanina Golino, Eleonora Vecchio, Giorgio Giurato, Selena Mimmi, Francesco Albano, Cristina Falcone, Domenico Britti
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 4, Pp 1-14 (2019)
Cell Death and Disease, Vol 10, Iss 4, Pp 1-14 (2019)
Increasing evidence supports the involvement of IBTK in cell survival and tumor growth. Previously, we have shown that IBTK RNA interference affects the wide genome expression and RNA splicing in cell-type specific manner. Further, the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58cb3c86b7bcd1465eedcee0b107002
http://hdl.handle.net/11386/4723158
http://hdl.handle.net/11386/4723158
Autor:
Simona Ceglia, Francesco Albano, Giuseppe Fiume, Marilena Pontoriero, Pierfrancesco Tassone, Marco Rossi, Antonio Pisano, Enrico Iaccino, Ileana Quinto, Gaetanina Golino, Giuseppe Scala, Camillo Palmieri, Federico Chiurazzi, Eleonora Vecchio, Antonio Lupia, Selena Mimmi
Publikováno v:
Leukemia
Evidence of shared epitopic reactivity among independent B-cell clones in chronic lymphocytic leukemia patients
Autor:
Antonio Pisano, Shibu Krishnan, Giuseppe Scala, Marilena Pontoriero, Annarita Scialdone, Marco Gaspari, Francesca Fasanella Masci, Selena Mimmi, Annamaria de Laurentiis, Enrico Iaccino, Rosanna Valea, Giovanni Cuda, Camillo Palmieri, Cristina Falcone, Ileana Quinto, Eleonora Vecchio, Simona Ceglia, Giuseppe Fiume
Publikováno v:
The Journal of Biological Chemistry
Background: IBtkα is an uncharacterized protein belonging to the family of BTB proteins. Results: IBtkα is the substrate receptor for a Cullin3-dependent ubiquitin ligase promoting ubiquitylation and proteasomal degradation of Pdcd4. Conclusion: By