Výsledky vyhledávání - "Simona Tomaselli"

Akademický článek

Antibacterial Properties of Polyurethane Foams Additivated with Terpenes from a Bio-Based Polyol

Autor: Simona Tomaselli, Fabio Bertini, Angelica Cifarelli, Adriano Vignali, Laura Ragona, Simona Losio

Publikováno v: Molecules, Vol 28, Iss 4, p 1966 (2023)

Water-blown polyurethane (PU) foams were prepared by bio-polyols from epoxidized linseed oils and caprylic acid in combination with toluene diisocianate (TDI). A series of terpenes (menthol, geraniol, terpineol, and borneol), natural compounds with r

Externí odkaz: https://doaj.org/article/11337077c11b4b6d8677804930c49889

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Akademický článek

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Autor: Katiuscia Pagano, Simona Tomaselli, Henriette Molinari, Laura Ragona

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders, with no cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) peptides are recognized as the main cause of AD progression, leading t

Externí odkaz: https://doaj.org/article/878361269cee42229ed8a6d9027e1e4d

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Bacteria as sensors: Real-time NMR analysis of extracellular metabolites detects sub-lethal amounts of bactericidal molecules released from functionalized materials

Autor: Simona Tomaselli, Mariacecilia Pasini, Erika Kozma, Umberto Giovanella, Guido Scavia, Katiuscia Pagano, Henriette Molinari, Salvatore Iannace, Laura Ragona

Publikováno v: Biochimica et biophysica acta. General subjects. 1867(1)

Cells exposed to stress factors experience time-dependent variations of metabolite concentration, acting as reliable sensors of the effective concentration of drugs in solution. NMR can detect and quantify changes in metabolite concentration, thus pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ffcfb2fcb5cbbc44800ae9eb1efe23
https://pubmed.ncbi.nlm.nih.gov/36228877

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Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization in Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer’s Disease

Autor: Gianluigi Forloni, Pietro La Vitola, Luca Banfi, Giulia Santamaria, Claudia Fracasso, Denise Galante, Claudia Balducci, Jacopo Lucchetti, Chiara Lambruschini, Laura Ragona, Simona Tomaselli, Cristina D'Arrigo, Edoardo Brandi, Katiuscia Pagano, Lisa Moni, Henriette Molinari

Publikováno v: ACS Chemical Neuroscience. 10:4462-4475

In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of Aβ42 oligomers, the most toxic species causing synaptic dysfunction, neuroinflammation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ea55cd5bf0c5868db078c86e657a73
https://doi.org/10.1021/acschemneuro.9b00241

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Akademický článek

BILE ACID BINDING PROTEIN: A VERSATILE HOST OF SMALL HYDROPHOBIC LIGANDS FOR APPLICATIONS IN THE FIELDS OF MRI CONTRAST AGENTS AND BIO-NANOMATERIALS

Autor: Katiuscia Pagano, Simona Tomaselli, Serena Zanzoni, Michael Assfalg, Henriette Molinari, Laura Ragona

Publikováno v: Computational and Structural Biotechnology Journal, Vol 6, Iss 7 (2013)

During the last decade a growing amount of evidence has been obtained, supporting the role of the beta-clamshell family of intracellular lipid binding proteins (iLBPs) not only in the translocation of lipophilic molecules but also in lipid mediated s

Externí odkaz: https://doaj.org/article/f6f40a6bd51247859685d7befd212183

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Molecular Basis of the Antiangiogenic Action of Rosmarinic Acid, a Natural Compound Targeting Fibroblast Growth Factor-2/FGFR Interactions

Autor: Giulia Taraboletti, Katiuscia Pagano, Laura Ragona, Laura Carminati, Simona Tomaselli, Henriette Molinari

Publikováno v: ChemBioChem
(2020).
info:cnr-pdr/source/autori:Katiuscia Pagano*[a], Laura Carminati [b], Simona Tomaselli [a], Henriette Molinari [a], Giulia Taraboletti [b] and Laura Ragona*[a]/titolo:Molecular basis of the antiangiogenic action of rosmarinic acid, a natural compound targeting Fibroblast Growth Factor-2%2FFGFR interactions/doi:/rivista:ChemBioChem (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Fibroblast growth factor (FGF2)/fibroblast growth factor receptor (FGFR) signalling plays a major role both in physiology and in several pathologies, including cancer development, metastasis formation and resistance to therapy. The development of sma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d052f9806f89e21a9cb20d3fa5b0bed4
https://pubmed.ncbi.nlm.nih.gov/32975328

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Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine

Autor: Simona Tomaselli, Laura Ragona, F. Samperi, Katiuscia Pagano, Silvia Destri, Umberto Giovanella, Francesco Galeotti, Giorgio Grisci, Wojciech Mróz, William Porzio

Publikováno v: Journal of Materials Chemistry B 3 (2015): 4892–4903. doi:10.1039/c5tb00679a
info:cnr-pdr/source/autori:Grisci G.; Mroz W.; Giovanella U.; Pagano K.; Porzio W.; Ragona L.; Samperi F.; Tomaselli S.; Galeotti F.; Destri S./titolo:Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine/doi:10.1039%2Fc5tb00679a/rivista:Journal of Materials Chemistry B/anno:2015/pagina_da:4892/pagina_a:4903/intervallo_pagine:4892–4903/volume:3

Conjugated polyelectrolytes (CPEs) have recently emerged as label-free materials for biosensing due to their intrinsic ability to transduce an amplified optical signal in response to interactions with different analytes. Herein, the conformational ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea28b648b0004feb290d81eb3d3588f7
https://pubmed.ncbi.nlm.nih.gov/32262678

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Natural Compounds as Inhibitors of A? Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Autor: Henriette Molinari, Katiuscia Pagano, Laura Ragona, Simona Tomaselli

Publikováno v: Frontiers in neuroscience
(2020).
info:cnr-pdr/source/autori:Katiuscia Pagano, Simona Tomaselli, Henriette Molinari and Laura Ragona/titolo:Natural Compounds as Inhibitors of A? Peptide Aggregation: Chemical Requirements and Molecular Mechanisms/doi:/rivista:Frontiers in neuroscience (Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e1a92d5bcf2c2519961e4e733c7535
http://www.cnr.it/prodotto/i/440372

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Akademický článek

Direct and allosteric inhibition of the FGF2/HSPGs/FGFR1 ternary complex formation by an antiangiogenic, thrombospondin-1-mimic small molecule.

Autor: Katiuscia Pagano, Rubben Torella, Chiara Foglieni, Antonella Bugatti, Simona Tomaselli, Lucia Zetta, Marco Presta, Marco Rusnati, Giulia Taraboletti, Giorgio Colombo, Laura Ragona

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36990 (2012)

Fibroblast growth factors (FGFs) are recognized targets for the development of therapies against angiogenesis-driven diseases, including cancer. The formation of a ternary complex with the transmembrane tyrosine kinase receptors (FGFRs), and heparan

Externí odkaz: https://doaj.org/article/061b20b1ac724c3e97bcd6d72331e2bd

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