Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Simona Distinto"'
Autor:
Shiu-Wen Huang, Ming Jen Hsu, Hsiu-Chen Chen, Rita Meleddu, Simona Distinto, Elias Maccioni, Filippo Cottiglia
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractThe phytochemical investigation of the methanol extract of the seeds of Magydaris pastinacea afforded two undescribed benzofuran glycosides, furomagydarins A-B (1, 2), together with three known coumarins. The structures of the new isolates we
Externí odkaz:
https://doaj.org/article/4ede0bc6e01e44d398ce55962401b995
Autor:
Daniela Secci, Erica Sanna, Simona Distinto, Alessia Onali, Antonio Lupia, Laura Demuru, Giulia Atzeni, Rita Meleddu, Filippo Cottiglia, Andrea Angeli, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Molecules, Vol 29, Iss 18, p 4444 (2024)
Human Carbonic Anhydrases (hCA) are enzymes that contribute to cancer’s development and progression. Isoforms IX and XII have been identified as potential anticancer targets, and, more specifically, hCA IX is overexpressed in hypoxic tumor cells, w
Externí odkaz:
https://doaj.org/article/df5f80cd728340e8a291dc5da994202e
Autor:
Lisa Sequeira, Simona Distinto, Rita Meleddu, Marco Gaspari, Andrea Angeli, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering the high pharmacological potential of the chromene scaffold as selective ligand of the IX an
Externí odkaz:
https://doaj.org/article/608a90cbda4941e490d99c961256b83c
Autor:
Angela Corona, Rita Meleddu, Olivier Delelis, Frederic Subra, Filippo Cottiglia, Francesca Esposito, Simona Distinto, Elias Maccioni, Enzo Tramontano
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
In the effort to identify and develop new HIV-1 inhibitors endowed with innovative mechanisms, we focused our attention on the possibility to target more than one viral encoded enzymatic function with a single molecule. In this respect, we have previ
Externí odkaz:
https://doaj.org/article/e76955d00e3c468984a0ef7bc516ae20
Autor:
Rita Meleddu, Serenella Deplano, Elias Maccioni, Francesco Ortuso, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Andrea Angeli, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Simona Distinto
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 685-692 (2021)
A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carboni
Externí odkaz:
https://doaj.org/article/b4e1f0d1e7d5471eb96942409fad975f
Autor:
Benedetta Fois, Angela Corona, Enzo Tramontano, Simona Distinto, Elias Maccioni, Rita Meleddu, Pierluigi Caboni, Costantino Floris, Filippo Cottiglia
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 749-757 (2021)
Bioassay-guided fractionation of the ethyl acetate extract from Teucrium flavum subsp. glaucum, endowed with inhibitory activity towards the HIV-1 reverse transcriptase–associated RNase H function, led to the isolation of salvigenin (1), cirsimarit
Externí odkaz:
https://doaj.org/article/d6c2cdb23685453bad1bac9f008c7cb8
Autor:
Benedetta Fois, Simona Distinto, Rita Meleddu, Serenella Deplano, Elias Maccioni, Costantino Floris, Antonella Rosa, Mariella Nieddu, Pierluigi Caboni, Claudia Sissi, Andrea Angeli, Claudiu T. Supuran, Filippo Cottiglia
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 539-548 (2020)
In an in vitro screening for human carbonic anhydrase (hCA) inhibiting agents from higher plants, the petroleum ether and ethyl acetate extracts of Magydaris pastinacea seeds selectively inhibited hCA IX and hCA XII isoforms. The phytochemical invest
Externí odkaz:
https://doaj.org/article/ba38eeee14924a808934f20776c11ded
Autor:
Simona Distinto, Rita Meleddu, Francesco Ortuso, Filippo Cottiglia, Serenella Deplano, Lisa Sequeira, Claudia Melis, Benedetta Fois, Andrea Angeli, Clemente Capasso, Rossella Angius, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1526-1533 (2019)
A library of 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzene-1-sulphonamides (EMAC8002a–m) was designed and synthesised to evaluate the effect of substituents in the positions 3 and 4 of the dihydrothiazole ring on the inhibitor
Externí odkaz:
https://doaj.org/article/3c9f17df024d4132a83d710a56a3090b
Autor:
Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, Elias Maccioni, Enzo Tramontano, Oriana Tabarrini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 55-74 (2019)
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2
Externí odkaz:
https://doaj.org/article/b4e8f0c07ca642ccb28f0ad18fbcbe9c
Autor:
Claudia Melis, Rita Meleddu, Andrea Angeli, Simona Distinto, Giulia Bianco, Clemente Capasso, Filippo Cottiglia, Rossella Angius, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 68-73 (2017)
The isatin scaffold is the constitutive fragment of several natural and synthetic bioactive molecules. Albeit several benzene sulphonamide-based carbonic anhydrase inhibitors (CAIs) have been reported, only recently isatin benzene sulphonamides have
Externí odkaz:
https://doaj.org/article/8e3c55a9ca1043289f5af1d682be8f71