Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Simona, Rapposelli"'
Autor:
Maria Marchese, Sara Bernardi, Asahi Ogi, Rosario Licitra, Giada Silvi, Serena Mero, Daniele Galatolo, Nicola Gammaldi, Stefano Doccini, Gian Michele Ratto, Simona Rapposelli, Stephan C.F. Neuhauss, Jingjing Zang, Silvia Rocchiccioli, Elena Michelucci, Elisa Ceccherini, Filippo M. Santorelli
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106536- (2024)
CLN8 is an endoplasmic reticulum cargo receptor and a regulator of lysosome biogenesis whose loss of function leads to neuronal ceroid lipofuscinosis. CLN8 has been linked to autophagy and lipid metabolism, but much remains to be learned, and there a
Externí odkaz:
https://doaj.org/article/bd2e6d5478aa489c96203c1abf34b6d7
Autor:
Andrea Caddeo, Marina Serra, Francesca Sedda, Andrea Bacci, Clementina Manera, Simona Rapposelli, Amedeo Columbano, Andrea Perra, Marta Anna Kowalik
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionSeveral lines of evidence suggest that the thyroid hormone signaling pathway is altered in patients with NAFLD and that pharmacological strategies to target the thyroid hormone/thyroid hormone nuclear receptor axis (TH/THR) in the liver m
Externí odkaz:
https://doaj.org/article/12be0e61ed8d46dc99ce7eb38fd5f8db
Autor:
Rebecca Ferrisi, Francesca Gado, Beatrice Polini, Caterina Ricardi, Kawthar A. Mohamed, Lesley A. Stevenson, Gabriella Ortore, Simona Rapposelli, Giuseppe Saccomanni, Roger G. Pertwee, Robert B. Laprairie, Clementina Manera, Grazia Chiellini
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
It is well known that G protein–coupled receptors (GPCRs) assume multiple active states. Orthosteric ligands and/or allosteric modulators can preferentially stabilize specific conformations, giving rise to pathway-biased signaling. One of the most
Externí odkaz:
https://doaj.org/article/2b848fee1ff74619863f32ed3419e73b
Autor:
Vito Antonio Baldassarro, Corinne Quadalti, Massimiliano Runfola, Clementina Manera, Simona Rapposelli, Laura Calzà
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1207 (2023)
Oligodendrocytes and their precursors are the cells responsible for developmental myelination and myelin repair during adulthood. Their differentiation and maturation processes are regulated by a complex molecular machinery driven mainly by triiodoth
Externí odkaz:
https://doaj.org/article/398aa36f048c4a6289a0411069f6cdb8
Autor:
Graeme Barker, Simona Rapposelli
Publikováno v:
Molecules, Vol 28, Iss 15, p 5632 (2023)
The field of synthetic methodology plays a pivotal role in the quest for safe and effective drugs [...]
Externí odkaz:
https://doaj.org/article/a0cc854949ef4721b8209ca56627ffde
Autor:
Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins, Agnieszka Szopa, Marcelo Villagran, Lorena Mardones, Miquel Martorell, Anca Oana Docea, Daniela Calina
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-21 (2021)
Abstract The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Ch
Externí odkaz:
https://doaj.org/article/ac9dc371255a4f8db9439b66372d4632
Autor:
Francesco Bertoni, Simona Rapposelli
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/2860f24028874a54a5c711b50d440a3c
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/fa95b6df8af943e89f0c6c123f3461ea
Autor:
Aikaterini Emmanouilidi, Chanse A. Fyffe, Riccardo Ferro, Charlotte E. Edling, Emily Capone, Simona Sestito, Simona Rapposelli, Rossano Lattanzio, Stefano Iacobelli, Gianluca Sala, Tania Maffucci, Marco Falasca
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Abstract Background The very aggressive nature and low survival rate of pancreatic ductal adenocarcinoma (PDAC) dictates the necessity to find novel efficacious therapies. Recent evidence suggests that phosphoinositide 3-kinase (PI3K) and 3-phosphoin
Externí odkaz:
https://doaj.org/article/7a7c4d16610446cf847b2d32f06af08d
Autor:
Andrea Bacci, Francesca Corsi, Massimiliano Runfola, Simona Sestito, Ilaria Piano, Clementina Manera, Giuseppe Saccomanni, Claudia Gargini, Simona Rapposelli
Publikováno v:
Pharmaceuticals, Vol 15, Iss 6, p 688 (2022)
Overproduction of reactive oxygen species (ROS) and alterations in metallostasis are common and related hallmarks in several neurodegenerative diseases (NDDs). Nature-based derivatives always represent an attractive tool in MTDL drug design, especial
Externí odkaz:
https://doaj.org/article/01cccc83f1664f2b81c758eca66ebccf