Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Simona, Polo"'
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114970- (2024)
Externí odkaz:
https://doaj.org/article/b2ea199df0684449960748dac3c283bb
Autor:
Orhi Barroso-Gomila, Laura Merino-Cacho, Veronica Muratore, Coralia Perez, Vincenzo Taibi, Elena Maspero, Mikel Azkargorta, Ibon Iloro, Fredrik Trulsson, Alfred C. O. Vertegaal, Ugo Mayor, Felix Elortza, Simona Polo, Rosa Barrio, James D. Sutherland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Hundreds of E3 ligases play a critical role in recognizing specific substrates for modification by ubiquitin (Ub). Separating genuine targets of E3s from E3-interactors remains a challenge. We present BioE3, a powerful approach for matching
Externí odkaz:
https://doaj.org/article/4ccb7e7077984547931c1b4504e71284
Autor:
Luca Menin, Janine Weber, Stefano Villa, Emanuele Martini, Elena Maspero, Carlos A. Niño, Valeria Cancila, Alessandro Poli, Paolo Maiuri, Andrea Palamidessi, Emanuela Frittoli, Fabrizio Bianchi, Claudio Tripodo, Kylie J. Walters, Fabio Giavazzi, Giorgio Scita, Simona Polo
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 113001- (2023)
Summary: Tissue fluidification and collective motility are pivotal in regulating embryonic morphogenesis, wound healing, and tumor metastasis. These processes frequently require that each cell constituent of a tissue coordinates its migration activit
Externí odkaz:
https://doaj.org/article/22953853652d4619b8b280426582d615
Autor:
Valentina Fajner, Fabio Giavazzi, Simona Sala, Amanda Oldani, Emanuele Martini, Francesco Napoletano, Dario Parazzoli, Giuliana Cesare, Roberto Cerbino, Elena Maspero, Thomas Vaccari, Simona Polo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Ribonucleoprotein (RNP) granules are responsible for mRNA transport and local translation required for neuronal and oocyte maturation. Here the authors show that loss of the Drosophila Ub ligase Hecw enlarges RNP granules, leads to a liquid to gel-li
Externí odkaz:
https://doaj.org/article/80abb9b6aba7465aa4f6053e0a5e349f
Autor:
Francesco Napoletano, Gloria Ferrari Bravo, Ilaria Anna Pia Voto, Aurora Santin, Lucia Celora, Elena Campaner, Clara Dezi, Arianna Bertossi, Elena Valentino, Mariangela Santorsola, Alessandra Rustighi, Valentina Fajner, Elena Maspero, Federico Ansaloni, Valeria Cancila, Cesare Fabio Valenti, Manuela Santo, Osvaldo Basilio Artimagnella, Sara Finaurini, Ubaldo Gioia, Simona Polo, Remo Sanges, Claudio Tripodo, Antonello Mallamaci, Stefano Gustincich, Fabrizio d’Adda di Fagagna, Fiamma Mantovani, Valeria Specchia, Giannino Del Sal
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109694- (2021)
Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, inc
Externí odkaz:
https://doaj.org/article/e42ceae700674016b2bc9029cf16e18c
Autor:
Matteo Biancospino, Gwen R. Buel, Carlos A. Niño, Elena Maspero, Rossella Scotto di Perrotolo, Andrea Raimondi, Lisa Redlingshöfer, Janine Weber, Frances M. Brodsky, Kylie J. Walters, Simona Polo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Clathrin light chains (CLCa and CLCb) are major constituents of clathrin-coated vesicles. Here authors find and structurally characterize the selective interaction between CLCa and the actin motor protein myosin VI which act together to generate the
Externí odkaz:
https://doaj.org/article/8f91af4c82334c6394eedff499f3dee1
Autor:
Aaron S. Dhanda, Connie Yu, Katarina T. Lulic, A. Wayne Vogl, Valentina Rausch, Diana Yang, Benjamin J. Nichols, Sung Hyun Kim, Simona Polo, Carsten G. Hansen, Julian A. Guttman
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Listeria monocytogenes moves from one cell to another using actin-rich membrane protrusions that propel the bacterium toward neighboring cells. Despite cholesterol being required for this transfer process, the precise host internalization me
Externí odkaz:
https://doaj.org/article/f192d030cbcf439984a879535aeec796
Autor:
Kevin B Myant, Patrizia Cammareri, Michael C Hodder, Jimi Wills, Alex Von Kriegsheim, Balázs Győrffy, Mamun Rashid, Simona Polo, Elena Maspero, Lynsey Vaughan, Basanta Gurung, Evan Barry, Angeliki Malliri, Fernando Camargo, David J Adams, Antonio Iavarone, Anna Lasorella, Owen J Sansom
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 2, Pp 181-197 (2016)
Abstract Cancer genome sequencing projects have identified hundreds of genetic alterations, often at low frequencies, raising questions as to their functional relevance. One exemplar gene is HUWE1, which has been found to be mutated in numerous studi
Externí odkaz:
https://doaj.org/article/bef900f514eb4dfa924a42f8550e2f55
Autor:
Wolfgang Wagner, Kristina Lippmann, Frank F. Heisler, Kira V. Gromova, Franco L. Lombino, Mona K. Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R. Schwarz, Jens Eilers, Matthias Kneussel
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 11-20.e9 (2019)
Summary: Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons. We find that myosin VI localizes at cer
Externí odkaz:
https://doaj.org/article/afe916e1b356400f8e150af47c713128
Autor:
Roberta Pascolutti, Veronica Algisi, Alexia Conte, Andrea Raimondi, Mithun Pasham, Srigokul Upadhyayula, Raphael Gaudin, Tanja Maritzen, Elisa Barbieri, Giusi Caldieri, Chiara Tordonato, Stefano Confalonieri, Stefano Freddi, Maria Grazia Malabarba, Elena Maspero, Simona Polo, Carlo Tacchetti, Volker Haucke, Tom Kirchhausen, Pier Paolo Di Fiore, Sara Sigismund
Publikováno v:
Cell Reports, Vol 27, Iss 10, Pp 3049-3061.e6 (2019)
Summary: Adaptor protein 2 (AP2) is a major constituent of clathrin-coated pits (CCPs). Whether it is essential for all forms of clathrin-mediated endocytosis (CME) in mammalian cells is an open issue. Here, we demonstrate, by live TIRF microscopy, t
Externí odkaz:
https://doaj.org/article/621ad877eaa14894b7e9f36e39fad5bd