Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Simona, Bianco"'
Autor:
Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Andrea Fontana, Francesca Vercellone, Mattia Conte, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 can re-structure chromatin organization and alter the epigenomic landscape of the host genome, but the mechanisms that produce such changes remain unclear. Here, we use polymer physics to investigate how the chromatin of the host
Externí odkaz:
https://doaj.org/article/34229b608a134e5c8d7dae241dafcf19
Autor:
Mattia Conte, Ehsan Irani, Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Two main mechanisms have been proposed to shape 3D genome architecture - loop extrusion and phase separation. Here the authors combine these mechanisms in polymer models in a manner that best fits 3D genome, based on both Hi-C and super-resolution lo
Externí odkaz:
https://doaj.org/article/5970e283afc74da1b576894812c227e8
Publikováno v:
Biophysical Reports, Vol 2, Iss 3, Pp 100070- (2022)
It is unclear how the length of a repetitive DNA tract determines the onset and progression of repeat expansion diseases, but the dynamics of secondary DNA structures formed by repeat sequences are believed to play an important role. It was recently
Externí odkaz:
https://doaj.org/article/2df4a8e74b124d479b112cef3f96548e
Autor:
Mattia Conte, Luca Fiorillo, Simona Bianco, Andrea M. Chiariello, Andrea Esposito, Mario Nicodemi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The molecular and physical mechanisms underlying chromatin folding at the single DNA molecule level remain poorly understood. Here, the authors use polymer modeling to investigate the conformations of two 2Mb-wide DNA loci in normal and cohesin deple
Externí odkaz:
https://doaj.org/article/83550059761641128b264d751599f703
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3660 (2023)
Understanding the mechanisms underlying the complex 3D architecture of mammalian genomes poses, at a more fundamental level, the problem of how two or multiple genomic sites can establish physical contacts in the nucleus of the cells. Beyond stochast
Externí odkaz:
https://doaj.org/article/f702cac95b1247da9214a43cdb7a2534
Autor:
Mattia Conte, Andrea M. Chiariello, Alex Abraham, Simona Bianco, Andrea Esposito, Mario Nicodemi, Tommaso Matteuzzi, Francesca Vercellone
Publikováno v:
Algorithms, Vol 15, Iss 9, p 330 (2022)
Recent super-resolution imaging technologies enable tracing chromatin conformation with nanometer-scale precision at the single-cell level. They revealed, for example, that human chromosomes fold into a complex three-dimensional structure within the
Externí odkaz:
https://doaj.org/article/90a28e8cd81a410caf0cdfbbaf6fac64
Autor:
Andrea Esposito, Alex Abraham, Mattia Conte, Francesca Vercellone, Antonella Prisco, Simona Bianco, Andrea M. Chiariello
Publikováno v:
Polymers, Vol 14, Iss 9, p 1918 (2022)
Within cell nuclei, several biophysical processes occur in order to allow the correct activities of the genome such as transcription and gene regulation. To quantitatively investigate such processes, polymer physics models have been developed to unve
Externí odkaz:
https://doaj.org/article/b4a6e09632f744ffa1e971a86c45315e
Autor:
Loredana Poeta, Michela Malacarne, Agnese Padula, Denise Drongitis, Lucia Verrillo, Maria Brigida Lioi, Andrea M. Chiariello, Simona Bianco, Mario Nicodemi, Maria Piccione, Emanuela Salzano, Domenico Coviello, Maria Giuseppina Miano
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3084 (2022)
The X-linked gene encoding aristaless-related homeobox (ARX) is a bi-functional transcription factor capable of activating or repressing gene transcription, whose mutations have been found in a wide spectrum of neurodevelopmental disorders (NDDs); th
Externí odkaz:
https://doaj.org/article/4a7bce0dd2454bdfa17af3f3648600a7
Autor:
Federica N Vigotti, Carlo Di Benedetto, Fabrizio Fop, Simona Bianco, Donatella Bilucaglia, Giulio Cesano
Publikováno v:
Clinical Kidney Journal. 16:541-548
BackgroundInterest in point-of-care ultrasound (POCUS) and lung ultrasound (LUS) is growing in the nephrology and dialysis field, and the number of nephrologists skilled in what is proving to be the “5th pillar of bedside physical examination” is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8a79e5606309a36feb1adadf06d1720
https://doi.org/10.1093/ckj/sfac250
https://doi.org/10.1093/ckj/sfac250
Autor:
Irene Salamon, Simone Serio, Simona Bianco, Christina Pagiatakis, Silvia Crasto, Andrea M. Chiariello, Mattia Conte, Paola Cattaneo, Luca Fiorillo, Arianna Felicetta, Elisa di Pasquale, Paolo Kunderfranco, Mario Nicodemi, Roberto Papait, Gianluigi Condorelli
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101539- (2020)
Summary: Enhancer RNAs (eRNAs) are a subset of long noncoding RNA generated from genomic enhancers: they are thought to act as potent promoters of the expression of nearby genes through interaction with the transcriptional and epigenomic machineries.
Externí odkaz:
https://doaj.org/article/1c45108cf33d43c585a27b5c9e5e722c