Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Autor: James L. Weaver, Grainne A. Tobin, Taylor Ingle, Simona Bancos, David Stevens, Rodney Rouse, Kristina E. Howard, David Goodwin, Alan Knapton, Xiaohong Li, Katherine Shea, Sharron Stewart, Lin Xu, Peter L. Goering, Qin Zhang, Paul C. Howard, Jessie Collins, Saeed Khan, Kidon Sung, Katherine M. Tyner

Publikováno v: Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-14 (2017)

Abstract Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate

Externí odkaz: https://doaj.org/article/785283ca27204af9b663b605868fcf5a

Skin Sensitization Testing Needs and Data Uses by U.S. Regulatory and Research Agencies

Autor: Naomi Hudson, Abigail Jacobs, Surender Ahir, Amber B. Daniel, Emily N. Reinke, Cecilia Aguila, Joanna Matheson, Judy Strickland, Simona Bancos, David M. Lehmann, Stanislav Vukmanovic, Evisabel Craig, David Allen, Dori R. Germolec, Chandramallika Ghosh, Nakissa Sadrieh, Nicole Kleinstreuer

United States regulatory and research agencies may rely upon skin sensitization test data to assess the sensitization hazards associated with dermal exposure to chemicals and products. These data are evaluated to ensure that such substances will not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ec0856875aeac992204463a7947d88
https://europepmc.org/articles/PMC6363849/

Evaluating the potential of gold, silver, and silica nanoparticles to saturate mononuclear phagocytic system tissues under repeat dosing conditions

Autor: Saeed A. Khan, Paul C. Howard, Qin Zhang, Taylor Ingle, David Goodwin, Kidon Sung, David L Stevens, Grainne A. McMahon Tobin, Alan Knapton, Katherine Shea, Lin Xu, Jessie Collins, James L. Weaver, Rodney Rouse, Peter L. Goering, Katherine M. Tyner, Simona Bancos, Xiaohong Li, Sharron Stewart, Kristina E. Howard

Publikováno v: Particle and Fibre Toxicology
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-14 (2017)

Background As nanoparticles (NPs) become more prevalent in the pharmaceutical industry, questions have arisen from both industry and regulatory stakeholders about the long term effects of these materials. This study was designed to evaluate whether g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6be9374a86e3ff913a3b09a034d493
https://doi.org/10.1186/s12989-017-0206-4

Immunotoxicity Testing for Drug–Nanoparticle Conjugates: Regulatory Considerations

Autor: Katherine M. Tyner, Simona Bancos, James L. Weaver

Publikováno v: Handbook of Immunological Properties of Engineered Nanomaterials: Volume 1: Key Considerations for Nanoparticle Characterization Prior to Immunotoxicity Studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7235a111632b7529f43394fd6378c563
https://doi.org/10.1142/9789813140431_0009

Evaluation of Viability and Proliferation Profiles on Macrophages Treated with Silica Nanoparticles In Vitro via Plate-Based, Flow Cytometry, and Coulter Counter Assays

Autor: Katherine M. Tyner, Simona Bancos, De-Hao Tsai, Vincent A. Hackley, James L. Weaver

Publikováno v: ISRN Nanotechnology. 2012:1-11

Nanoparticles (NPs) are known to interfere with many high-throughput cell viability and cell proliferation assays, which complicates the assessment of their potential toxic effects. The aim of this study was to compare viability and proliferation res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e8ec70f86ca08a5814275cdb8bad9a
https://doi.org/10.5402/2012/454072