Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Simon. J. Davis"'
Autor:
Rita F. Santos, Annika de Sousa Linhares, Peter Steinberger, Simon. J. Davis, Liliana Oliveira, Alexandre M. Carmo
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background T-cell membrane scaffold proteins are pivotal in T cell function, acting as versatile signaling hubs. While CD6 forms a large intracellular signalosome, it is distinguished from typical scaffolds like LAT or PAG by possessing a su
Externí odkaz:
https://doaj.org/article/e75938de1adf4148a1f3617d7c5720b5
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The mechanistic detail of how PD-1 inhibits T cell activation is lacking. Here, the authors show PD-1 suppresses the cooperative TCR–pMHC–CD8 interaction by inhibiting TCR proximal signalling.
Externí odkaz:
https://doaj.org/article/2e4502623e2b43e3b586f623ee548395
Autor:
Johannes Pettmann, Anna Huhn, Enas Abu Shah, Mikhail A Kutuzov, Daniel B Wilson, Michael L Dustin, Simon J Davis, P Anton van der Merwe, Omer Dushek
Publikováno v:
eLife, Vol 10 (2021)
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) antigens. Although the discriminatory power of the TCR is widely believed
Externí odkaz:
https://doaj.org/article/bcd2f1d193024b08b393a17283f277a4
Autor:
Hayden Pearce, Wayne Croft, Samantha M. Nicol, Sandra Margielewska-Davies, Richard Powell, Richard Cornall, Simon J. Davis, Francesca Marcon, Matthew R. Pugh, Éanna Fennell, Sarah Powell-Brett, Brinder S. Mahon, Rachel M. Brown, Gary Middleton, Keith Roberts, Paul Moss
Publikováno v:
Cancer Immunology Research. 11:435-449
Pancreatic ductal adenocarcinoma (PDAC) has a poor clinical outlook. Responses to immune checkpoint blockade are suboptimal and a much more detailed understanding of the tumor immune microenvironment is needed if this situation is to be improved. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bac2cbbe3a03a5478871da3e2da07fb
https://doi.org/10.1158/2326-6066.cir-22-0121
https://doi.org/10.1158/2326-6066.cir-22-0121
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic development, but how they contribute to immune responses in the periphery is unclear. Coreceptors strengthen T-cell responses by many orders of magnitude – bey
Externí odkaz:
https://doaj.org/article/718d990dbd3f4b5ab090986fc4573a64
Autor:
James H. Felce, Sarah L. Latty, Rachel G. Knox, Susan R. Mattick, Yuan Lui, Steven F. Lee, David Klenerman, Simon J. Davis
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2654-2665 (2017)
The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of mostly individual receptors. Here, we use a large-scal
Externí odkaz:
https://doaj.org/article/ac280b470ad0472b9932a24d661938b7
Autor:
Sam Daly, João Ferreira Fernandes, Ezra Bruggeman, Anoushka Handa, Ruby Peters, Sarah Benaissa, Boya Zhang, Joseph S. Beckwith, Edward W. Sanders, Ruth R. Sims, David Klenerman, Simon J. Davis, Kevin O’Holleran, Steven F. Lee
Volumetric super-resolution microscopy typically encodes the 3D position of single-molecule fluorescence into a 2D image by changing the shape of the point spread function (PSF) as a function of depth. However, the resulting large and complex PSF spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56296e81d2b17318b183bf80ce855b1f
https://doi.org/10.1101/2023.05.02.539032
https://doi.org/10.1101/2023.05.02.539032
Autor:
Paul Moss, Keith Roberts, Gary Middleton, Rachel M. Brown, Brinder S. Mahon, Sarah Powell-Brett, Éanna Fennell, Matthew R. Pugh, Francesca Marcon, Simon J. Davis, Richard Cornall, Richard Powell, Sandra Margielewska-Davies, Samantha M. Nicol, Wayne Croft, Hayden Pearce
Supplementary Figures S1 - S12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e42f4ba5f8a45010341e7e26126c08b
https://doi.org/10.1158/2326-6066.22551825.v1
https://doi.org/10.1158/2326-6066.22551825.v1
Autor:
Paul Moss, Keith Roberts, Gary Middleton, Rachel M. Brown, Brinder S. Mahon, Sarah Powell-Brett, Éanna Fennell, Matthew R. Pugh, Francesca Marcon, Simon J. Davis, Richard Cornall, Richard Powell, Sandra Margielewska-Davies, Samantha M. Nicol, Wayne Croft, Hayden Pearce
Supplementary Tables 1 - 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e74e530824afb1115fdefea5b5c60d5
https://doi.org/10.1158/2326-6066.22551822.v1
https://doi.org/10.1158/2326-6066.22551822.v1
Autor:
Paul Moss, Keith Roberts, Gary Middleton, Rachel M. Brown, Brinder S. Mahon, Sarah Powell-Brett, Éanna Fennell, Matthew R. Pugh, Francesca Marcon, Simon J. Davis, Richard Cornall, Richard Powell, Sandra Margielewska-Davies, Samantha M. Nicol, Wayne Croft, Hayden Pearce
Pancreatic ductal adenocarcinoma (PDAC) has a poor clinical outlook. Responses to immune checkpoint blockade are suboptimal and a much more detailed understanding of the tumor immune microenvironment is needed if this situation is to be improved. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0956501f70c6005fb8627d9a6f61d847
https://doi.org/10.1158/2326-6066.c.6534790.v2
https://doi.org/10.1158/2326-6066.c.6534790.v2