Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Simon Wing Fai Mok"'
Autor:
Lusha Ye, Yanan Gao, Simon Wing Fai Mok, Wucan Liao, Yazhou Wang, Changjiang Chen, Lijun Yang, Junfeng Zhang, Liyun Shi
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Acute lung injury (ALI) is generally caused by severe respiratory infection and characterized by overexuberant inflammatory responses and inefficient pathogens-containing, the two major processes wherein alveolar macrophages (AMs) play a cen
Externí odkaz:
https://doaj.org/article/50c887b161164c778bd6fa4334ebcecf
Autor:
Congling Qiu, Joyce Tsz Wai Chan, David Wei Zhang, Io Nam Wong, Yaling Zeng, Betty Yuen Kwan Law, Simon Wing Fai Mok, Ivo Ricardo De Seabra Rodrigues Dias, Wenfeng Liu, Liang Liu, Vincent Kam Wai Wong
Publikováno v:
Genes and Diseases, Vol 10, Iss 6, Pp 2252-2255 (2023)
Externí odkaz:
https://doaj.org/article/5d7f0cc244d6412cbdeec013857b1e51
Autor:
Wu Zeng, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Denise So Bik Chan, Simon Wing Fai Mok, Joyce Jia Ying Gao, Rebecca Ka Yan Ho, Xu Liang, Jia Hao Li, Ming Tsung Lee, Weng Li Yoon, Michael P Smolinski, Johnson Yiu Nam Lau, Christopher Wai Kei Lam, Manson Fok
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 4, Pp 986-1001 (2020)
Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulati
Externí odkaz:
https://doaj.org/article/0a638d70084946c8a525f147a5248048
Autor:
Hu-Qiang He, Yuan-Qing Qu, Betty Yuen Kwan Law, Cong-ling Qiu, Yu Han, Ivo Ricardo de Seabra Rodrigues Dias, Yong Liu, Jie Zhang, An-Guo Wu, Cheng-Wen Wu, Simon Wing Fai Mok, Xin Cheng, Yan-Zheng He, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Vascular calcification (VC) in macrovascular and peripheral blood vessels is one of the main factors leading to diabetes mellitus (DM) and death. Apart from the induction of vascular calcification, advanced glycation end products (AGEs) have also bee
Externí odkaz:
https://doaj.org/article/4b7f905b414c44b99a985a416da7afa0
Autor:
Yu Han, Yuan Qing Qu, Simon Wing Fai Mok, Juan Chen, Cheng Lai Xia, Hu Qiang He, Zheng Li, Wei Zhang, Cong Ling Qiu, Liang Liu, Betty Yuen Kwan Law, Vincent Kam Wai Wong
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The pro-apoptotic proteins BAX and BAK are critical regulatory factors constituting the apoptosis machinery. Downregulated expression of BAX and BAK in human colorectal cancer lead to chemotherapeutic failure and poor survival rate in patients. In th
Externí odkaz:
https://doaj.org/article/5c8c439b126d4e95b582f89f28097f77
Autor:
Betty Yuen Kwan Law, Simon Wing Fai Mok, An Guo Wu, Christopher Wai Kei Lam, Margaret Xin Yi Yu, Vincent Kam Wai Wong
Publikováno v:
Molecules, Vol 21, Iss 3, p 359 (2016)
Autophagy is a universal catabolic cellular process for quality control of cytoplasm and maintenance of cellular homeostasis upon nutrient deprivation and environmental stimulus. It involves the lysosomal degradation of cellular components such as mi
Externí odkaz:
https://doaj.org/article/8f2fd500c88043889087a52a5dce9a68
Autor:
Rebecca Lucinda Ka Yan Ho, Manson Fok, Joyce Jia Ying Gao, Michael Smolinski, Jia Hao Li, Weng Li Yoon, Denise So Bik Chan, Johnson Y.N. Lau, Wu Zeng, Christopher W.K. Lam, Betty Yuen Kwan Law, Ming Tsung Lee, Vincent Kam Wai Wong, Simon Wing Fai Mok, Xu Liang
Publikováno v:
Cancer Biology & Medicine, Vol 17, Iss 4, Pp 986-1001 (2020)
Objective: Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owing to the presence of the blood-brain barrier and the activity of P-gp, which pumps its substrate back into the systemic circulati
Autor:
Hui Zhong, Hongjiao Yu, Jiaxin Chen, Simon Wing Fai Mok, Xiao Tan, Bohou Zhao, Shengping He, Lan Lan, Xiaodong Fu, Guojun Chen, Dongxing Zhu
Publikováno v:
Vascular pharmacology. 146
Recent studies have shown that short-chain fatty acids (SCFAs), primarily acetate, propionate and butyrate, play a crucial role in the pathogenesis of cardiovascular disease. Whether SCFAs regulate vascular calcification, a common pathological change
Autor:
Liang Liu, Yuesheng Xie, Xi Chen, Francesco Michelangeli, Hui Wang, Wen Jing Yu, Hudan Pan, Zheng Li, Riqiang Luo, Vincent Kam Wai Wong, Wu Zeng, Yuan Qing Qu, Sami Hamdoun, Wei Zhang, Lu Yu, Betty Yuen Kwan Law, Quan Jiang, Congling Qiu, Thomas Efferth, Ni Zhang, Simon Wing Fai Mok, Su-Wei Xu, Yu Han, Tsz Wai Chan, Ivo Ricardo de Seabra Rodrigues Dias
Publikováno v:
British Journal of Pharmacology
Background and purpose Celastrol exhibits anti-arthritic effects in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca2+ mobilization in treatment of RA remains undefined. Here, we describe a regulatory role for celastrol-induced Ca2+ s
Autor:
Betty Yuen Kwan Law, Li-Ping Bai, Vincent Kam Wai Wong, Simon Wing Fai Mok, Xiaobo Zhou, Zhiyuan Zheng, Yuan Qing Qu, Zhi-Hong Jiang
Publikováno v:
Bioorganic Chemistry. 83:450-460
Eleven dauricine derivatives were synthesized and evaluated for their anti-cancer effect in different cancer cells and their autophagic activity in HeLa model cell. Among these newly synthesized compounds, carbamates 2a, 2b, carbonyl ester 3a and sul