Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Simon Walker-Samuel"'
Autor:
Emmeline E. Brown, Andrew A. Guy, Natalie A. Holroyd, Paul W. Sweeney, Lucie Gourmet, Hannah Coleman, Claire Walsh, Athina E. Markaki, Rebecca Shipley, Ranjan Rajendram, Simon Walker-Samuel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Disruption of retinal vasculature is linked to various diseases, including diabetic retinopathy and macular degeneration, leading to vision loss. We present here a novel algorithmic approach that generates highly realistic digital models of
Externí odkaz:
https://doaj.org/article/0bd85a757e2e4546b32f953ae15e0ae5
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-15 (2024)
Abstract Background Carcinogenesis is driven by interactions between genetic mutations and the local tumor microenvironment. Recent research has identified hundreds of cancer driver genes; however, these studies often include a mixture of different m
Externí odkaz:
https://doaj.org/article/d17d69192e5c43688aed0b790d34f27f
Autor:
Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored
Externí odkaz:
https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Though the earliest stages of oncogenesis, post initiation, are not well understood, it is generally appreciated that a successful transition from a collection of dysregulated cells to an aggressive tumour requires complex ecological interactions bet
Externí odkaz:
https://doaj.org/article/cc3302d94c7c46689c2622b91331b85c
Autor:
Lucie E. Gourmet, Simon Walker-Samuel
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Complex interactions between the physical environment and phenotype of a tumour, and genomics, transcriptomics, proteomics and epigenomics, are increasingly known to have a significant influence on cancer development, progression and evolution. For e
Externí odkaz:
https://doaj.org/article/6083704a5ae54830ab26c945ef909352
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 909 (2023)
Episcopic imaging using techniques such as High Resolution Episcopic Microscopy (HREM) and its variants, allows biological samples to be visualized in three dimensions over a large field of view. Quantitative analysis of episcopic image data is under
Externí odkaz:
https://doaj.org/article/a06e279e05be49d48a2e50e4b7e8d845
Autor:
Claire Walsh, Natalie A. Holroyd, Eoin Finnerty, Sean G. Ryan, Paul W. Sweeney, Rebecca J. Shipley, Simon Walker-Samuel
Publikováno v:
Advanced Photonics Research, Vol 2, Iss 10, Pp n/a-n/a (2021)
3D microscopy of large biological samples (>0.5 cm3) is transforming biological research. Many existing techniques require trade‐offs between image resolution, sample size, and method complexity. A simple robust instrument with the potential to con
Externí odkaz:
https://doaj.org/article/cfa969a5416c441580ee03800430a4df
Autor:
Hannah West, Fiona Roberts, Paul Sweeney, Simon Walker-Samuel, Joseph Leedale, Helen Colley, Craig Murdoch, Rebecca J Shipley, Steven Webb
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254208 (2021)
Nanoparticles have the potential to increase the efficacy of anticancer drugs whilst reducing off-target side effects. However, there remain uncertainties regarding the cellular uptake kinetics of nanoparticles which could have implications for nanop
Externí odkaz:
https://doaj.org/article/81b955807a9144d8933128dc95e0bd7e
Autor:
Yanan Zhu, Rajiv Ramasawmy, Sean Peter Johnson, Valerie Taylor, Alasdair Gibb, R. Barbara Pedley, Nibedita Chattopadhyay, Mark F. Lythgoe, Xavier Golay, Daniel Bradley, Simon Walker-Samuel
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Proteasome inhibitors (PIs) are now standard of care for several cancers, and noninvasive biomarkers of treatment response are critically required for early patient stratification and treatment personalization. The present study evaluated wh
Externí odkaz:
https://doaj.org/article/f8952b03910249259df62b0f5a1bc8a4
Autor:
Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe, Claire L Walsh, Rosa Maria Correra, Paul JD Winyard, Peter C Harris, Christiana Ruhrberg, Simon Walker-Samuel, Paul R Riley, Adrian S Woolf, Peter J Scambler, David A Long
Publikováno v:
eLife, Vol 8 (2019)
Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ. We performed three
Externí odkaz:
https://doaj.org/article/19f52d73e1eb45febdf317aa6d8af0b5