Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Simon W L Chan"'
Autor:
Sundaram Kuppu, Ek Han Tan, Hanh Nguyen, Andrea Rodgers, Luca Comai, Simon W L Chan, Anne B Britt
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005494 (2015)
The centromeric histone 3 variant (CENH3, aka CENP-A) is essential for the segregation of sister chromatids during mitosis and meiosis. To better define CENH3 functional constraints, we complemented a null allele in Arabidopsis with a variety of muta
Externí odkaz:
https://doaj.org/article/9bf1478bdce74187aed7eb6c2ff529fa
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004970 (2015)
The point of attachment of spindle microtubules to metaphase chromosomes is known as the centromere. Plant and animal centromeres are epigenetically specified by a centromere-specific variant of Histone H3, CENH3 (a.k.a. CENP-A). Unlike canonical his
Externí odkaz:
https://doaj.org/article/fcc44ea0bb674116945fed613f8cbd96
Autor:
Maruthachalam Ravi, Fukashi Shibata, Joseph S Ramahi, Kiyotaka Nagaki, Changbin Chen, Minoru Murata, Simon W L Chan
Publikováno v:
PLoS Genetics, Vol 7, Iss 6, p e1002121 (2011)
Centromere behavior is specialized in meiosis I, so that sister chromatids of homologous chromosomes are pulled toward the same side of the spindle (through kinetochore mono-orientation) and chromosome number is reduced. Factors required for mono-ori
Externí odkaz:
https://doaj.org/article/c67eb75c7dcb44cc86471f151ab92174
Autor:
Mohan P. A. Marimuthu, Ravi Maruthachalam, Ramesh Bondada, Anne B. Britt, Luca Comai, Sundaram Kuppu, Simon W. L. Chan, Ek Han Tan
Publikováno v:
Science Advances
Science advances, vol 7, iss 47
Science advances, vol 7, iss 47
Description
CENH3 variation mediates parental centromere imbalance.
Wide crosses result in postzygotic elimination of one parental chromosome set, but the mechanisms that result in such differential fate are poorly understood. Here, we show
CENH3 variation mediates parental centromere imbalance.
Wide crosses result in postzygotic elimination of one parental chromosome set, but the mechanisms that result in such differential fate are poorly understood. Here, we show
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e363 (2006)
Tandem repeat sequences are frequently associated with gene silencing phenomena. The Arabidopsis thaliana FWA gene contains two tandem repeats and is an efficient target for RNA-directed de novo DNA methylation when it is transformed into plants. We
Externí odkaz:
https://doaj.org/article/977bca0b2bad4901a7e57c939438808d
Autor:
Nazatul Shima Naharudin, Joost J. B. Keurentjes, Maruthachalam Ravi, Cilia L C Lelivelt, Simon W. L. Chan, Hans de Jong, Rob Dirks, Erik Wijnker, C Bastiaan de Snoo, Kees van Dun
Publikováno v:
Nature Genetics 44 (2012)
Nature Genetics, 44, 467-470
Nature Genetics, 44, 467-470
Traditionally, hybrid seeds are produced by crossing selected inbred lines. Here we provide a proof of concept for reverse breeding, a new approach that simplifies meiosis such that homozygous parental lines can be generated from a vigorous hybrid in
Autor:
Isabelle M. Henry, Maruthachalam Ravi, Danelle K. Seymour, Andy Pang, Jennifer Monson-Miller, Simon W. L. Chan, Daniele L. Filiault, Julin N. Maloof, Luca Comai
Publikováno v:
Proceedings of the National Academy of Sciences. 109:4227-4232
Quantitative trait loci (QTL) mapping is a powerful tool for investigating the genetic basis of natural variation. QTL can be mapped using a number of different population designs, but recombinant inbred lines (RILs) are among the most effective. Unf
Autor:
Maxim V. C. Greenberg, Matteo Pellegrini, Simon W. L. Chan, James C. Carrington, Josh T. Cuperus, Steven E. Jacobsen, Israel Ausin, Julie A. Law, Suhua Feng, Shawn J. Cokus, Carolyn Chu
Publikováno v:
Epigenetics
Epigenetics, Taylor & Francis, 2014, 6 (3), pp.344-354. ⟨10.4161/epi.6.3.14242⟩
Epigenetics, Taylor & Francis, 2014, 6 (3), pp.344-354. ⟨10.4161/epi.6.3.14242⟩
De novo DNa methylation in Arabidopsis thaliana is catalyzed by the methyltransferase DRM2, a homolog of the mammalian de novo methyltransferase DNMT3. DRM2 is targeted to DN a by small interfering RNas ( siRNas ) in a process known as RNa- directed
Autor:
Simon W. L. Chan
Publikováno v:
Trends in Biotechnology. 28:605-610
The term "chromosome engineering" describes technologies in which chromosomes are manipulated to change their mode of genetic inheritance. This review examines recent innovations in chromosome engineering that promise to greatly increase the efficien
Autor:
Pak N. Kwong, Robert K. Tran, Jodi L. Stewart, Ron M. G. Menorca, Joseph S. Ramahi, Joel T. Valencia, Venkatesan Sundaresan, Simon W. L. Chan, Luca Comai, Maruthachalam Ravi
Publikováno v:
Genetics. 186:461-471
Centromeres control chromosome inheritance in eukaryotes, yet their DNA structure and primary sequence are hypervariable. Most animals and plants have megabases of tandem repeats at their centromeres, unlike yeast with unique centromere sequences. Ce