Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Simon Wöhrle"'
Autor:
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Wöhrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Géraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Protein degraders are an emerging drug modality; however, their properties lie beyond typical drug-like space. Here the authors report optimisation via structure-based exit vector and linker design towards the VHL-recruiting PROTAC ACBI2, an orally b
Externí odkaz:
https://doaj.org/article/3f90550853c6402d8f154d10f8e2a18c
Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells
Autor:
Simone Lieb, Silvia Blaha-Ostermann, Elisabeth Kamper, Janine Rippka, Cornelia Schwarz, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Andreas Wernitznig, Jesse J Lipp, Kota Nagasaka, Petra van der Lelij, Gerd Bader, Minoru Koi, Ajay Goel, Ralph A Neumüller, Jan-Michael Peters, Norbert Kraut, Mark A Pearson, Mark Petronczki, Simon Wöhrle
Publikováno v:
eLife, Vol 8 (2019)
Targeted cancer therapy is based on exploiting selective dependencies of tumor cells. By leveraging recent functional screening data of cancer cell lines we identify Werner syndrome helicase (WRN) as a novel specific vulnerability of microsatellite i
Externí odkaz:
https://doaj.org/article/bcf5373f995c49dd883a2b357adfa700
Autor:
Simon Wöhrle, Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami, Zainab Jagani, Anne Thuery, Beatrice Bauer-Probst, Flavia Reimann, Christelle Stamm, Astrid Pornon, Vincent Romanet, Vito Guagnano, Thomas Brümmendorf, William R Sellers, Francesco Hofmann, Charles W M Roberts, Diana Graus Porta
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77652 (2013)
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1. MRTs are poorly responsive to chemotherapy and thus a high unmet clinic
Externí odkaz:
https://doaj.org/article/5ddabf7e37d840fe9ce647ad449900b5
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
PDF file - 1.4MB, Response to NVP-BGJ398; FGFR pathway modulation by NVP-BGJ398; NVP-BGJ398 - predictive features; FGFR2-c3 mRNA expression in cell lines and FGFR2 DNA copy number in tumors; FGF19 DNA copy number in CCLE cell lines and FGFR3 DNA copy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055d71ccbe50a65e308a5319a0af558a
https://doi.org/10.1158/2159-8290.22529469
https://doi.org/10.1158/2159-8290.22529469
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 99K, Kinase activity and selectivity for NVP-BGJ398; CCLE cell lines sensitive to NVP-BGJ398; GeneSet expression signatures; FGFR genetic alterations and concomitant mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394b8c19ed3865b26c4b23f7077d34aa
https://doi.org/10.1158/2159-8290.22529463.v1
https://doi.org/10.1158/2159-8290.22529463.v1
Autor:
Diana Graus-Porta, William R. Sellers, Francesco Hofmann, Carlos Garcia-Echeverria, David M. Thomas, Thomas Brümmendorf, Kavitha Venkatesan, John E. Monahan, Jason Borawski, L. Alex Gaither, Mickaël Le Douget, Vincent Bordas, Christopher J. Wilson, Zhi Chen, Yun Zhang, Fang Li, Yao Yao, Astrid Pornon, Louise Barys, Moriko Ito, Christelle Stamm, Simon Wöhrle, Audrey Kauffmann, Vito Guagnano
XML file - 56K, High throughput pharmacological screen of BGJ398 in 517 cancer cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2881a9c58817a03993b13427e5d262a1
https://doi.org/10.1158/2159-8290.22529466.v1
https://doi.org/10.1158/2159-8290.22529466.v1
Autor:
Roland Kousek, Dirk Kessler, Stephan Karl Zahn, Jens Bruchhaus, Darryl B. McConnell, Mark Pearson, Franziska Moser, Bernhard Wolkerstorfer, Dennis Breitsprecher, Maximilian Scharnweber, Teresa Puchner, Georg Dahmann, Philipp Baaske, Julian E. Fuchs, Sandra Döbel, Wolfgang Hela, Christiane Kofink, Klaus Rumpel, Leonhard Geist, Simon Wöhrle, Andreas Bergner, Moriz Mayer, Jark Böttcher, Patrick Werni, Markus Zeeb, Maike Dettling, Tuncay Ciftci
Publikováno v:
Chemmedchem
Aberrant WNT pathway activation, leading to nuclear accumulation of β‐catenin, is a key oncogenic driver event. Mutations in the tumor suppressor gene APC lead to impaired proteasomal degradation of β‐catenin and subsequent nuclear translocatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bddd2c4cb79fde7e745f2b35f2c8e2
https://doi.org/10.1002/cmdc.202000839
https://doi.org/10.1002/cmdc.202000839
Autor:
Manfred Koegl, Simon Wöhrle
Publikováno v:
Target Discovery and Validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78624d5521c568fb3d2c8c928956aaf8
https://doi.org/10.1002/9783527818242.ch8
https://doi.org/10.1002/9783527818242.ch8
Autor:
Stefan Kornigg, Junwei Shi, Thomas Zichner, Janine Rippka, Stephan Karl Zahn, Christopher R. Vakoc, Mark Pearson, Gerd Bader, Silvia Blaha-Ostermann, Wolfgang Sommergruber, Mark Petronczki, Cornelia Schwarz, Norbert Kraut, Ralph A. Neumüller, Teresa Puchner, Alexandra Hörmann, Katharina Ehrenhöfer-Wölfer, Andreas Schlattl, Norbert Schweifer, Ursula Strobl, Simon Wöhrle, Manfred Kögl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
SMARCA4/BRG1 and SMARCA2/BRM, the two mutually exclusive catalytic subunits of the BAF complex, display a well-established synthetic lethal relationship in SMARCA4-deficient cancers. Using CRISPR-Cas9 screening, we identify SMARCA4 as a novel depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf48c313f689e413e0af35cf86b007ea
http://link.springer.com/article/10.1038/s41598-019-48152-x
http://link.springer.com/article/10.1038/s41598-019-48152-x
Autor:
Anna Köferle, Andreas Schlattl, Alexandra Hörmann, Fiona Spreitzer, Alexandra Popa, Venu Thatikonda, Teresa Puchner, Verena Supper, Madhwesh C. Ravichandran, Sarah Oberndorfer, Corinna Wieshofer, Maja Corcokovic, Christoph Reiser, Simon Wöhrle, Johannes Popow, Mark Pearson, Barbara Mair, Ralph A. Neumüller
Publikováno v:
Cancer Research. 82:4004-4004
Genetic networks are characterized by extensive buffering. During tumor evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eef1d7607419cdd22e074905dbf74f20
https://doi.org/10.1158/1538-7445.am2022-4004
https://doi.org/10.1158/1538-7445.am2022-4004