Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Simon Vézina-Dawod"'
Autor:
Simon Vézina-Dawod, Stéphane Gobeil, Nicolas Gerber, Louis-David Guay, Eric Biron, Martin Perreault
Publikováno v:
Bioorganic & Medicinal Chemistry. 45:116314
A novel tumor suppressing agent was discovered against PC-3 prostate cancer cells from the screening of a 1,4-benzodiazepin-3-one library. In this study, 96 highly diversified 2,4,5-trisubstituted 1,4-benzodiazepin-3-one derivatives were prepared by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51369b52aab7ff458443536e548380b7
https://doi.org/10.1016/j.bmc.2021.116314
https://doi.org/10.1016/j.bmc.2021.116314
Publikováno v:
Tetrahedron. 73:6347-6355
Benzodiazepinones are an important family of heterocycles with very attractive pharmacological properties and peptidomimetic abilities. We report herein a rapid and efficient two-step synthesis of polysubstituted 1,4-benzodiazepin-3-ones and 1,5-benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53487eac101b27a0d9866fc18e1aa791
https://doi.org/10.1016/j.tet.2017.09.028
https://doi.org/10.1016/j.tet.2017.09.028
Publikováno v:
Organic Letters. 18:1174-1177
A novel dual ring-opening/cleavage strategy to determine the sequence of cyclic peptides from one bead, one compound libraries is described. The approach uses a photolabile residue within the macrocycle and as a linker to allow a simultaneous ring op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59b59d604feb268b151bdf758f929bb
https://doi.org/10.1021/acs.orglett.6b00296
https://doi.org/10.1021/acs.orglett.6b00296
Publikováno v:
Organic Letters. 17:5626-5629
To increase the chemical diversity accessible with peptoids and peptide-peptoid hybrids, N-alkylated arylsulfonamides were used to prepare side chain protected N-substituted glycines compatible with solid-phase synthesis. The described procedures giv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2eebd28eae5fba68536b7bba09aae3d
https://doi.org/10.1021/acs.orglett.5b02862
https://doi.org/10.1021/acs.orglett.5b02862
Publikováno v:
Tetrahedron Letters. 56:382-385
Peptoids (oligo N-substituted glycines) are peptidomimetic oligomers showing attractive structural and pharmacological properties. The efficiency of their synthesis has prompted the use of peptoids in combinatorial libraries. To increase the chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4144de55fa1f8a470c388adaeee3ad40
https://doi.org/10.1016/j.tetlet.2014.11.104
https://doi.org/10.1016/j.tetlet.2014.11.104
Publikováno v:
Practical Medicinal Chemistry with Macrocycles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::779be2828e4e0bed2e48027f5efb2be1
https://doi.org/10.1002/9781119092599.ch9
https://doi.org/10.1002/9781119092599.ch9
Autor:
Xinxia Liang, Simon Vézina-Dawod, Eric Biron, Sindy-Marcela Galindo, Steve Jobin, Alexia Méjean
Publikováno v:
Organicbiomolecular chemistry. 14(47)
A new methodology to couple peptide fragments on solid support using a traceless isocyanide-based multicomponent reaction is described. The approach uses a microwave-assisted on-resin Ugi four-component reaction to attach a carboxyl free peptide to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2b0217c774ce3d9c887a4c7ea0ab4c
https://pubmed.ncbi.nlm.nih.gov/27841889
https://pubmed.ncbi.nlm.nih.gov/27841889
Autor:
Simon Vézina-Dawod, Louis-Jean Bordeleau, Marie E. Perrin, Eric Biron, Stéphane Gobeil, Sophie Fortin
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
Peptide macrocycles are useful tools in chemical biology and for the development of therapeutic compounds. Compared to their linear counterparts, cyclic peptides are more resistant to proteases and their increased conformational rigidity makes them t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::532b8ef529a964690fbe0e5c4287048b
https://doi.org/10.17952/24aps.2015.127
https://doi.org/10.17952/24aps.2015.127
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
Peptoids (oligo N-substituted glycines) are peptidomimetic oligomers showing attractive structural and pharmacological properties for the development of therapeutic candidates and molecular tools [1,2]. Compared to peptides, peptoids are resistant to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c6c7499cd46a81729a315f4fba7b907
https://doi.org/10.17952/24aps.2015.280
https://doi.org/10.17952/24aps.2015.280
Publikováno v:
Peptides 2015, Proceedings of the 24th American Peptide Symposium.
With a great therapeutic potential, peptide macrocycles have gained a lot of interest in drug discovery. Compared to their linear counterparts, cyclic peptides show improved resistance to proteases and their increased conformational rigidity lowers t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d6c1e5dd937679030bcf25e53b3fcfa
https://doi.org/10.17952/24aps.2015.122
https://doi.org/10.17952/24aps.2015.122