Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Simon Trent"'
Autor:
Ana I. Silva, Josephine E. Haddon, Yasir Ahmed Syed, Simon Trent, Tzu-Ching E. Lin, Yateen Patel, Jenny Carter, Niels Haan, Robert C. Honey, Trevor Humby, Yaniv Assaf, Michael J. Owen, David E. J. Linden, Jeremy Hall, Lawrence S. Wilkinson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
People with a genetic deletion of the 15q11.2 locus are at increased risk for psychiatric disorders and white matter disturbances, but the gene(s) responsible are unclear. Here, the authors show that low dosage of CYFIP1, present in the human 15q11.2
Externí odkaz:
https://doaj.org/article/411296870f6b40bf8e1be35dea45f741
Autor:
Nicholas E. Clifton, Darren Cameron, Simon Trent, Lucy H. Sykes, Kerrie L. Thomas, Jeremy Hall
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to synaptic pl
Externí odkaz:
https://doaj.org/article/9edd78f770b14f949c1009aad133f959
Publikováno v:
Complex Psychiatry
There is increasing awareness of the role genetic risk variants have in mediating vulnerability to psychiatric disorders such as schizophrenia and autism. Many of these risk variants encode synaptic proteins, influencing biological pathways of the po
Publikováno v:
Molecular neuropsychiatry. 5(3)
Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits over the course of development and the adult processes of learning and memory. Synaptic plasticity requires the rearrangement of protein complexes in the
Activity-regulated cytoskeleton-associated protein (Arc) supports fear memory through synaptic plasticity events requiring actin cytoskeleton rearrangements. We have previously shown that reducing hippocampal Arc levels through antisense knockdown le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c15217cd5bef387b3fbd72ce0b2946d
Autor:
Rachel Dean, Tommaso Cassano, William Davies, Trevor Humby, Simon Trent, Bonnie Veit, Gaurav Bedse, Obah A. Ojarikre
Publikováno v:
Psychoneuroendocrinology
Chromosomal deletions at Xp22.3 appear to influence vulnerability to the neurodevelopmental disorders attention deficit hyperactivity disorder (ADHD) and autism. 39,X(Y*)O mice, which lack the murine orthologue of the Xp22.3 ADHD candidate gene STS (
Publikováno v:
Trent, S, Drew, C J G, Mitchell, P J & Bailey, S J 2009, ' Chronic treatment with 13-cis-retinoic acid changes aggressive behaviours in the resident-intruder paradigm in rats ', European Neuropsychopharmacology, vol. 19, no. 12, pp. 876-886 . https://doi.org/10.1016/j.euroneuro.2009.07.003
Retinoids, vitamin A related compounds, have an established role in the development of the nervous system and are increasingly recognized to play a role in adult brain function. The synthetic retinoid, 13-cis-retinoic acid (13-cis-RA, Roaccutane) is
Publikováno v:
Experimental Biology and Medicine. 232:1195-1203
In addition to their established role in nervous system development, vitamin A and related retinoids are emerging as regulators of adult brain function. Accutane (13- cis-retinoic acid, isotretinoin) treatment has been reported to increase depression
Publikováno v:
Nature Communications
Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454e9ba8a050d04353089e4ce883547a
https://eprints.keele.ac.uk/7713/1/ncomms8897.pdf
https://eprints.keele.ac.uk/7713/1/ncomms8897.pdf
Publikováno v:
Biological psychiatry. 77(1)
Recent large-scale genomic studies have revealed two broad classes of risk alleles for schizophrenia: a polygenic component of risk mediated through multiple common risk variants and rarer more highly penetrant submicroscopic chromosomal deletions an