Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Simon Topp Christensen"'
Autor:
Kristian Agmund Haanes, Karin Warfvinge, Stine Spray, Sara Ellinor Johansson, Lars Edvinsson, Simon Topp Christensen, Anne-Sofie Grell
Publikováno v:
Clinical Science. 133:1797-1811
Background: Aneurysmal subarachnoid haemorrhage (SAH) is a variant of haemorrhagic stroke with a striking 50% mortality rate. In addition to the initial insult, secondary delayed brain injury may occur days after the initial ischemic insult and is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9279bdafe257aa35101cac33a7cbc499
https://doi.org/10.1042/cs20190636
https://doi.org/10.1042/cs20190636
Autor:
C. M. Andersson, Sara Ellinor Johansson, Simon Topp Christensen, Anne-Sofie Grell, Kristian Agmund Haanes, Lars Edvinsson
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 680-688 (2019)
Christensen, S T, Grell, A S, Johansson, S E, Andersson, C M, Edvinsson, L & Haanes, K A 2019, ' Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model ', Drug Delivery, vol. 26, no. 1, pp. 680-688 . https://doi.org/10.1080/10717544.2019.1636421
Christensen, S T, Grell, A S, Johansson, S E, Andersson, C M, Edvinsson, L & Haanes, K A 2019, ' Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model ', Drug Delivery, vol. 26, no. 1, pp. 680-688 . https://doi.org/10.1080/10717544.2019.1636421
Neuroprotection has proven clinically unsuccessful in subarachnoid hemorrhage. We believe that this is because the major component in the early damage pathway, the vascular wall, has not been given the necessary focus. U0126 is a potent inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295cc3f5d60852ddd4d630cba3326c8b
https://doaj.org/article/505284fc7dc74b85830b90a14aeaf3f7
https://doaj.org/article/505284fc7dc74b85830b90a14aeaf3f7
Autor:
Sara Ellinor Johansson, Kristian Agmund Haanes, Lars Edvinsson, Thomas Boettger, Thomas Braun, Karin Warfvinge, Simon Topp Christensen
Publikováno v:
Journal of cardiovascular pharmacology. 74(5)
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with a high short-term mortality rate which leads to cognitive impairments that reduce the quality of life of the majority of patients. The miRNA-143/145 cluster is highly expressed in vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38ef5c4ccfb56bbe09bebd914da18d2
https://pubmed.ncbi.nlm.nih.gov/31425342
https://pubmed.ncbi.nlm.nih.gov/31425342
Autor:
Lars Edvinsson, Sara Ellinor Johansson, Simon Topp Christensen, Kristian Agmund Haanes, Aneta Radziwon-Balicka, Karin Warfvinge
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215398 (2019)
Christensen, S T, Johansson, S E, Radziwon-Balicka, A, Warfvinge, K, Haanes, K A & Edvinsson, L 2019, ' MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats ', PLoS ONE, vol. 14, no. 4, e0215398 . https://doi.org/10.1371/journal.pone.0215398
Christensen, S T, Johansson, S E, Radziwon-Balicka, A, Warfvinge, K, Haanes, K A & Edvinsson, L 2019, ' MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats ', PLoS ONE, vol. 14, no. 4, e0215398 . https://doi.org/10.1371/journal.pone.0215398
Vascular pathophysiological changes after haemorrhagic stroke, such as phenotypic modulation of the cerebral arteries and cerebral vasospasms, are associated with delayed cerebral ischemia (DCI) and poor outcome. The only currently approved drug trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccafc0ce24a7e79295b5a60db23849c
https://doaj.org/article/20ca4763d19b4e399e65be7a12aab0d6
https://doaj.org/article/20ca4763d19b4e399e65be7a12aab0d6