Výsledky vyhledávání - "Simon Tomlinson"

Akademický článek

An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein

Publikováno v: eLife, Vol 7 (2018)

CRISPR/Cas9 can be used for precise genetic knock-in of epitope tags into endogenous genes, simplifying experimental analysis of protein function. However, Cas9-assisted epitope tagging in primary mammalian cell cultures is often inefficient and reli

Externí odkaz: https://doaj.org/article/75965eb632694dcb913174d34eba59b9

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Tissue, cell and stage specificity of (epi)mutations in cancers

Autor: Oliver M. Sieber, Simon Tomlinson, Ian Tomlinson

Publikováno v: Nature Reviews Cancer. 5:649-655

Most (epi)mutations in cancers are specific to particular tumours or occur at specific stages of development, cell differentiation or tumorigenesis. Simple molecular mechanisms, such as tissue-restricted gene expression, seem to explain these associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24bc0c7cd26ff9508bd571e340b07e37
https://doi.org/10.1038/nrc1674

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Relationships Among Murine CD11chigh Dendritic Cell Subsets as Revealed by Baseline Gene Expression Patterns

Autor: Simon Tomlinson, Alan Sher, Caetano Reis e Sousa, Damien Chaussabel, Oliver Schulz, Alexander D. Edwards

Publikováno v: Scopus-Elsevier
Europe PubMed Central

The functional relationships and properties of different subtypes of dendritic cells (DC) remain largely undefined. To better characterize these cells, we used global gene analysis to determine gene expression patterns among murine CD11chigh DC subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d40297698bb828a374f1956b2113019b
https://doi.org/10.4049/jimmunol.171.1.47

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Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events

Autor: J. A. L. Amess, Tracy Chaplin, Debra M. Lillington, Bryan D. Young, Silvana Debernardi, T. Andrew Lister, Ama Z. S. Rohatiner, Simon Tomlinson

Publikováno v: Genes, Chromosomes and Cancer. 37:149-158

Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML). Hierarchical clustering sorted the profiles into separate groups, each representing one of the major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c43f55942570bf9ad98d3a8789e067a
https://doi.org/10.1002/gcc.10198

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Are imaging and lesioning convergent methods for assessing functional specialisation?: investigations using an artificial neural network

Autor: Harry R M Purser, Simon Tomlinson, Michael S.C. Thomas, Denis Mareschal

Publikováno v: Brain and cognition. 78(1)

This article presents an investigation of the relationship between lesioning and neuroimaging methods of assessing functional specialisation, using synthetic brain imaging (SBI) and lesioning of a connectionist network of past-tense formation. The mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708daf8e97a365bed2d6180141fa53f5
https://pubmed.ncbi.nlm.nih.gov/22088777

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A phase II study of gefitinib monotherapy in advanced esophageal adenocarcinoma: evidence of gene expression, cellular, and clinical response

Autor: Kate Beddard, David Ferry, Paul A. Atherfold, Rebecca Harrison, Janusz Jankowski, Simon Tomlinson, Jolanta Obszynska, Mark Anderson

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 13(19)

Purpose: At presentation, most cases of adenocarcinoma of the esophagus (ACE) are inoperable. Although chemotherapy can prolong survival, patients eventually die as a result of refractory disease. Epidermal growth factor receptor (EGFR) is almost uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef43b0fae9b7c8dc5e45b486921cbad8
https://pubmed.ncbi.nlm.nih.gov/17908981

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Management of severe upper airway trauma

Autor: Simon Tomlinson, Chris Earlam

Publikováno v: Hospital medicine (London, England : 1998). 60(11)

A 32-year-old man presented to casualty at night following an accident at work with a large industrial circular saw. His overalls were caught by the blade and he was pulled into the machine. The blade had struck him on the left side of his face and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cc10643d82d41e1327bd17883da5a8
https://pubmed.ncbi.nlm.nih.gov/10707205

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Gene Expression Profiling Reveals Fundamental Differences between Leukemic Stem Cells (Lin-CD34+CD38−) and Mature Blasts (Lin−CD34+CD38+) of Acute Myeloid Leukaemia (AML) Patients

Autor: Kazem Zibara, Daniel J. Pearce, Bryan D. Young, Simon Tomlinson, David Taussig, Dominique Bonnet, Spyros Skoulakis, Emilie Bureau

Publikováno v: Blood. 106:1377-1377

The identification of LSC has important implications for future research as well as for the development of novel therapies. The phenotypic description of LSC now enables their purification and should facilitate the identification of genes that are pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1146c03ca522d5e91a1802b0d740a440
https://doi.org/10.1182/blood.v106.11.1377.1377

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