Zobrazeno 1 - 10
of 2 408
pro vyhledávání: '"Simon Thomas"'
Autor:
Johanna Sophie Lubasch, Patrick Andreas Eder, Christian Kaiser, Andrea Diana Klausen, Daniel Overheu, Anja Partheymüller, Asarnusch Rashid, Simon Thomas Schäfer, Maximilian Scharonow, Insa Seeger
Publikováno v:
BMC Health Services Research, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background By transmitting various types of data, telemedical care enables the provision of care where physicians and patients are physically separated. In nursing homes, telemedicine has the potential to reduce hospital admissions in noneme
Externí odkaz:
https://doaj.org/article/85086390b3a7453db435cab395101d10
Autor:
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden
Publikováno v:
NIHR Open Research, Vol 4 (2024)
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and va
Externí odkaz:
https://doaj.org/article/4a8d978b425241f8ad42b60aaffc7af5
Autor:
Mathieu Ferrari, Matteo Righi, Vania Baldan, Patrycja Wawrzyniecka, Anna Bulek, Alexander Kinna, Biao Ma, Reyisa Bughda, Zulaikha Akbar, Saket Srivastava, Isaac Gannon, Mathew Robson, James Sillibourne, Ram Jha, Mohamed El-Kholy, Oliver Muhammad Amin, Evangelia Kokalaki, Mohammed Amin Banani, Rehan Hussain, William Day, Wen Chean Lim, Priyanka Ghongane, Jade R. Hopkins, Dennis Jungherz, Marco Herling, Martin Welin, Sachin Surade, Michael Dyson, John McCafferty, Derek Logan, Shaun Cordoba, Simon Thomas, Andrew Sewell, Paul Maciocia, Shimobi Onuoha, Martin Pule
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Peripheral T cell lymphomas are typically aggressive with a poor prognosis. Unlike other hematologic malignancies, the lack of target antigens to discriminate healthy from malignant cells limits the efficacy of immunotherapeutic approaches.
Externí odkaz:
https://doaj.org/article/0a0cba1c19b24f4e8e75069f7a2b0924
Autor:
Terence W O'Neill, Robert Horne, Clare Jinks, Christian D Mallen, Zoe Paskins, Elaine Nicholls, Laurna Bullock, Stephanie Butler-Walley, Andrea Cherrington, Jane Fleming, Emma M Clark, Ida Bentley, Sarah Leyland, Cynthia P Iglesias-Urrutia, Simon Thomas, Jo Smith, David Webb, Sarah Lewis, Sarah Bathers, Michele Siciliano, Angela Clifford, Sarah Ryan, Joanne Protheroe, Nicky Dale, Janet Lefroy, Sarah Connacher, Ashley Hawarden
Publikováno v:
NIHR Open Research, Vol 4 (2024)
Background Good quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person’s life, beliefs, and va
Externí odkaz:
https://doaj.org/article/07dc988831154dada5a42fc40a8cfc71
Autor:
Callum McKenzie, Mohamed El-Kholy, Farhaan Parekh, Mathew Robson, Katarina Lamb, Christopher Allen, James Sillibourne, Shaun Cordoba, Simon Thomas, Martin Pule
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 603-621 (2023)
The hostile tumor microenvironment limits the efficacy of adoptive cell therapies. Activation of the Fas death receptor initiates apoptosis and disrupting these receptors could be key to increasing CAR T cell efficacy. We screened a library of Fas-TN
Externí odkaz:
https://doaj.org/article/3161044ecdb64eac92495eea73fe8a62
Autor:
Thomas Berger, David J. Noble, Leila E.A. Shelley, Thomas McMullan, Amy Bates, Simon Thomas, Linda J. Carruthers, George Beckett, Aileen Duffton, Claire Paterson, Raj Jena, Duncan B. McLaren, Neil G. Burnet, William H. Nailon
Publikováno v:
Physics and Imaging in Radiation Oncology, Vol 24, Iss , Pp 95-101 (2022)
Background and purpose: The images acquired during radiotherapy for image-guidance purposes could be used to monitor patient-specific response to irradiation and improve treatment personalisation. We investigated whether the kinetics of radiomics fea
Externí odkaz:
https://doaj.org/article/c397066d1e5c42ee933f25eafc73df64
Autor:
Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Kwee Yong, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Martin Pule
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background We used a proliferating ligand (APRIL) to construct a ligand-based third generation chimeric antigen receptor (CAR) able to target two myeloma antigens, B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor.Metho
Externí odkaz:
https://doaj.org/article/8067650d1c374058a81e8dfb09c80620
Autor:
Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Simon Thomas
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
SHP1 and SHP2 are SH2 domain-containing proteins which have inhibitory phosphatase activity when recruited to phosphorylated ITIMs and ITSMs on inhibitory immune receptors. Consequently, SHP1 and SHP2 are key proteins in the transmission of inhibitor
Externí odkaz:
https://doaj.org/article/e38d52e6c99944609c3459b7f08fd187
Autor:
James E Sillibourne, Giulia Agliardi, Matteo Righi, Katerina Smetanova, Grant Rowley, Simon Speller, Abigail Dolor, Katarina Lamb, Christopher Allen, Rajeev Karattil, Farhaan Parekh, Frederick Arce Vargas, Simon Thomas, Shaun Cordoba, Martin Pule
Publikováno v:
BioTechniques, Vol 72, Iss 4, Pp 143-154 (2022)
The development of multicistronic vectors enabling differential transgene expression is a goal of gene therapy and poses a significant engineering challenge. Current approaches rely on the insertion of long regulatory sequences that occupy valuable s
Externí odkaz:
https://doaj.org/article/378103da300e46c791933431ae4e6844
Autor:
Lydie Burglen, Evelien Van Hoeymissen, Leila Qebibo, Magalie Barth, Newell Belnap, Felix Boschann, Christel Depienne, Katrien De Clercq, Andrew GL Douglas, Mark P Fitzgerald, Nicola Foulds, Catherine Garel, Ingo Helbig, Katharina Held, Denise Horn, Annelies Janssen, Angela M Kaindl, Vinodh Narayanan, Christina Prager, Mailys Rupin-Mas, Alexandra Afenjar, Siyuan Zhao, Vincent Th Ramaekers, Sarah M Ruggiero, Simon Thomas, Stéphanie Valence, Lionel Van Maldergem, Tibor Rohacs, Diana Rodriguez, David Dyment, Thomas Voets, Joris Vriens
Publikováno v:
eLife, Vol 12 (2023)
TRPM3 is a temperature- and neurosteroid-sensitive plasma membrane cation channel expressed in a variety of neuronal and non-neuronal cells. Recently, rare de novo variants in TRPM3 were identified in individuals with developmental and epileptic ence
Externí odkaz:
https://doaj.org/article/40dfdc180e96470192bccc762e052743