Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Simon Terzyan"'
Autor:
Chinthalapally V. Rao, Nagendra Sastry Yarla, Anil Singh, Simon Terzyan, Venkateshwar Madka, Gopal Pathuri, Marcus Tullius Scotti, Hariprasad Gali
Publikováno v:
The FASEB Journal
Background : COVID‐19, a disease caused by a novel coronavirus, is a major global human threat that has turned into a pandemic. Identification and development of drugs/vaccines is urgently needed for prevention and therapy of the COVID‐19 virus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::243492554bc70ed5fcab272ebb70e225
https://doi.org/10.1096/fasebj.2021.35.s1.03597
https://doi.org/10.1096/fasebj.2021.35.s1.03597
Autor:
Simon Terzyan, Parthasarathy Chandrakesan, Hariprasad Gali, Janani Panneerselvam, Marcus Tullius Scotti, Nagendra Sastri Yarla, Courtney W. Houchen, Venkateshwar Madka, Chinthalapally V. Rao, Gopal Pathuri
Publikováno v:
Journal of Inflammation Research
Nagendra Sastri Yarla,1 Gopal Pathuri,1,2 Hariprasad Gali,2 Simon Terzyan,3 Janani Panneerselvam,1 Parthasarathy Chandrakesan,4 Marcus Tullius Scotti,5 Courtney Houchen,4 Venkateshwar Madka,1 Chinthalapally V Rao1,6 1Center for Cancer Prevention and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d7ba16add809145338091b0a57b5e6
https://www.dovepress.com/discovery-and-development-of-a-novel-mpges-15-lox-dual-inhibitor-lfa-9-peer-reviewed-article-JIR
https://www.dovepress.com/discovery-and-development-of-a-novel-mpges-15-lox-dual-inhibitor-lfa-9-peer-reviewed-article-JIR
Autor:
Blaine H. M. Mooers, P.T.T. Vo, Amini Behrang, Maria E. Cabanillas, Tao Shen, Vivek Subbiah, Funda Meric-Bernstam, Keyur P. Patel, Xuewu Liu, Jie Wu, Xueqing Hu, Mimi Hu, Simon Terzyan
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology
Background Selpercatinib (LOXO-292) and pralsetinib (BLU-667) are highly potent RET-selective protein tyrosine kinase inhibitors (TKIs) for treating advanced RET-altered thyroid cancers and non-small-cell lung cancer (NSCLC). It is critical to analyz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4041f6723990406ba01d61dc21b9b560
https://pubmed.ncbi.nlm.nih.gov/33161056
https://pubmed.ncbi.nlm.nih.gov/33161056
Autor:
Yuting Zhang, Nagendra Sastry Yarla, Chinthalapally V. Rao, Anil Singh, Gopal Pathuri, Venkateshwar Madka, Marcus Tullius Scotti, Simon Terzyan
Publikováno v:
Cancer Research. 81:LB074-LB074
Lung cancer patients are more vulnerable to COVID-19 infection. Treatment of patients with lung cancer during the current COVID-19 pandemic is challenging and development of drugs for COVID-19 and lung cancer is urgently needed. Cathepsin L plays key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd437fc0360e0f2f425c5e56000c6f2e
https://doi.org/10.1158/1538-7445.am2021-lb074
https://doi.org/10.1158/1538-7445.am2021-lb074
Publikováno v:
Protein Science. 26:1196-1205
Intense efforts are underway to identify inhibitors of the enzyme gamma-glutamyl transpeptidase 1 (GGT1) which cleaves extracellular gamma-glutamyl compounds and contributes to the pathology of asthma, reperfusion injury and cancer. The glutamate ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5968fc759ad92d343f3bef35174a74c4
https://doi.org/10.1002/pro.3172
https://doi.org/10.1002/pro.3172
Autor:
Qingling Huang, Jianfeng Cai, Simon Terzyan, Jie Wu, Frank Hilberg, Blaine H. M. Mooers, Xuan Liu, Tao Shen, Peng Teng, Mi Zhou
Publikováno v:
J Biol Chem
RET is a transmembrane growth factor receptor. Aberrantly activated RET is found in several types of human cancer and is a target for treating RET aberration-associated cancer. Multiple clinically relevant RET protein-tyrosine kinase inhibitors (TKIs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b26a28b0efa82d1dbf79e6caaf2cafa
https://pubmed.ncbi.nlm.nih.gov/31118272
https://pubmed.ncbi.nlm.nih.gov/31118272
Autor:
Youngjae You, Anthony W. G. Burgett, Annie Heroux, Marie H. Hanigan, Simon Terzyan, Luong T. Nguyen, Clyde A. Smith
Publikováno v:
The Journal of Biological Chemistry
Overexpression of γ-glutamyl transpeptidase (GGT1) has been implicated in an array of human diseases including asthma, reperfusion injury, and cancer. Inhibitors are needed for therapy, but development of potent, specific inhibitors of GGT1 has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4140e12f93deaa52a983b0df511e5b3f
https://doi.org/10.1074/jbc.ra120.016265
https://doi.org/10.1074/jbc.ra120.016265
Autor:
Clyde A. Smith, Annie Heroux, Simon Terzyan, Anthony W. G. Burgett, Blaine H. M. Mooers, Marie H. Hanigan
Publikováno v:
Journal of Biological Chemistry. 290:17576-17586
γ-Glutamyl transpeptidase 1 (GGT1) is a cell surface, N-terminal nucleophile hydrolase that cleaves glutathione and other γ-glutamyl compounds. GGT1 expression is essential in cysteine homeostasis, and its induction has been implicated in the patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6e2e043a902fabb598976bf10fb484
https://doi.org/10.1074/jbc.m115.659680
https://doi.org/10.1074/jbc.m115.659680
Autor:
Stephanie Wickham, Marie H. Hanigan, Nicholas Regan, Paul F. Cook, Matthew B. West, Simon Terzyan, Pui-Kai Li, Justin Thai
Publikováno v:
Biochemical Journal. 450:547-557
GGT (γ-glutamyl transpeptidase) is an essential enzyme for maintaining cysteine homoeostasis, leukotriene synthesis, metabolism of glutathione conjugates and catabolism of extracellular glutathione. Overexpression of GGT has been implicated in many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cc855e559cf64dcdb8016496960c93
https://doi.org/10.1042/bj20121435
https://doi.org/10.1042/bj20121435
Publikováno v:
Mol Immunol
We have previously reported accelerated acquisition of new autoreactivity upon immunization with 4-hydroxy-2-nonenal (HNE)-modified Ro60, as well as differential induction of lupus or Sjögren’s syndrome by immunization with Ro60 containing varying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ae140e710c200bc2dd07cd35db7719
https://doi.org/10.1016/j.molimm.2011.12.010
https://doi.org/10.1016/j.molimm.2011.12.010