Výsledky vyhledávání - "Simon Teague"

Akademický článek

Erratum to the paper: In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery

Autor: Klara Livia Valko, Simon Teague, Charles Pudgeon

Publikováno v: ADMET and DMPK, Vol 6, Iss 3, Pp 267-268 (2018)

The authors of the original paper published with the same title: ADMET & DMPK 5(1) (2017) 14-38; doi: 10.5599/admet.5.1.373, apologize for the error in the plot on Figure 5. The erratum gives a correct plot.

Externí odkaz: https://doaj.org/article/3c8a722d23134a3caacb683a88a247fd

Zobrazit plný text záznamu

iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System

Autor: Jayne E. Hastedt, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Anthony J. Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon Teague, Ulrika Tehler, Jennifer Wylie

Publikováno v: Molecular Pharmaceutics. 19:2032-2039

For oral drugs, the formulator and discovery chemist have a tool available to them that can be used to navigate the risks associated with the selection and development of immediate release oral drugs and drug products. This tool is the biopharmaceuti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324d60f5473a739c5702ca14cbb982f
https://doi.org/10.1021/acs.molpharmaceut.2c00113

Zobrazit plný text záznamu

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

Publikováno v: Journal of Medicinal Chemistry. 65:633-664

The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765

Zobrazit plný text záznamu

Multimodal imaging of drug and excipients in rat lungs following an inhaled administration of controlled-release drug laden PLGA microparticles

Autor: Brian Farrer, Eve Robinson, Joseph Marchand, Ian S. Gilmore, Meredith Earl, Rasmus Havelund, Diane M. Coe, Doug Ball, Dave Hassall, Simon Teague, Heather Reid, Rebecca Terry, Paul Giffen, Peter S. Marshall

Publikováno v: The Analyst. 146:3378-3390

Controlled-release formulations, in the form of micro- or nanoparticles, are increasingly attractive to the pharmaceutical industry for drug delivery. For respiratory illnesses, controlled-release microparticle formulations provide an opportunity to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fe7abaa0ea71988b3ca3f2d4610faa
https://doi.org/10.1039/d0an02333g

Zobrazit plný text záznamu

Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery

Publikováno v: Med. Chem. Commun.. 5:134-141

Using X-ray crystallographic screening, fragments 4 and 6 were identified as inhibitors of hematopoietic prostaglandin D2 synthase (H-PGDS). Both fragments induced a small protein movement in the X-ray crystal structure relative to the apo structure,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f3850d001e5b02755bbbe21405c11b8
https://doi.org/10.1039/c3md00280b

Zobrazit plný text záznamu

Erratum to the paper: In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery

Autor: Simon Teague, Klára Valkó, Charles Pudgeon

Publikováno v: ADMET and DMPK
Volume 6
Issue 3
ADMET and DMPK, Vol 6, Iss 3, Pp 267-268 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ef9ac1688af0f7fd088db136a1447
https://doi.org/10.5599/admet.568

Zobrazit plný text záznamu

How to identify and eliminate compounds with a risk of high clinical dose during the early phase of lead optimisation in drug discovery

Autor: Simon Teague, Klára Valkó

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 110

An alternative approach has been developed to estimate the clinical dose of new drug molecules at an early stage in the drug discovery process. This approach has been compared to traditional methods using the clinical dose as indicated on the drug la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b33a45f6f188cb5fb378908c12e04
https://pubmed.ncbi.nlm.nih.gov/28215942

Zobrazit plný text záznamu

Acylglycinamides as inhibitors of glycine transporter type 1

Autor: Laurie J. Gordon, Gemma V. Puckey, Wyman Paul Adrian, David John Nash, Richard Blunt, Hugh J. Herdon, Simon Teague, Victoria Hadden, Stefano Fontana, Amanda Johns, Roderick A. Porter

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 21:6176-6179

A screening hit was used as the basis for the core structure of a new series of acylglycinamide GlyT-1 inhibitors. Investigation of the SAR around four areas of diversity used facile chemistry to prepare compounds quickly. By focussing on reducing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f8f89eeb234cf21b05ae54fe2cbc7a
https://doi.org/10.1016/j.bmcl.2011.07.096

Zobrazit plný text záznamu

In vitro membrane binding and protein binding (IAM MB/PB technology) to estimate in vivo distribution: applications in early drug discovery

Autor: Simon Teague, Klára Valkó, Charles Pidgeon

Publikováno v: ADMET and DMPK, Vol 5, Iss 1, Pp 14-38 (2017)
ADMET and DMPK
Volume 5
Issue 1

The drug discovery process can be accelerated by chromatographic profiling of the analogs to model in vivo distribution and the major non-specific binding. A balanced potency and chromatographically determined membrane and protein binding (IAM MB/PB)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc8a261b9b179948e988cd3ca72293c
https://doi.org/10.5599/admet.5.1.373

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání