Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Simon Teague"'
Autor:
Jayne E. Hastedt, Per Bäckman, Antonio Cabal, Andy Clark, Carsten Ehrhardt, Ben Forbes, Anthony J. Hickey, Guenther Hochhaus, Wenlei Jiang, Stavros Kassinos, Philip J. Kuehl, David Prime, Yoen-Ju Son, Simon Teague, Ulrika Tehler, Jennifer Wylie
Publikováno v:
Molecular Pharmaceutics. 19:2032-2039
For oral drugs, the formulator and discovery chemist have a tool available to them that can be used to navigate the risks associated with the selection and development of immediate release oral drugs and drug products. This tool is the biopharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e324d60f5473a739c5702ca14cbb982f
https://doi.org/10.1021/acs.molpharmaceut.2c00113
https://doi.org/10.1021/acs.molpharmaceut.2c00113
Autor:
Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe
Publikováno v:
Journal of Medicinal Chemistry. 65:633-664
The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765
https://doi.org/10.1021/acs.jmedchem.1c01765
Publikováno v:
ADMET and DMPK, Vol 6, Iss 3, Pp 267-268 (2018)
The authors of the original paper published with the same title: ADMET & DMPK 5(1) (2017) 14-38; doi: 10.5599/admet.5.1.373, apologize for the error in the plot on Figure 5. The erratum gives a correct plot.
Externí odkaz:
https://doaj.org/article/3c8a722d23134a3caacb683a88a247fd
Autor:
Brian Farrer, Eve Robinson, Joseph Marchand, Ian S. Gilmore, Meredith Earl, Rasmus Havelund, Diane M. Coe, Doug Ball, Dave Hassall, Simon Teague, Heather Reid, Rebecca Terry, Paul Giffen, Peter S. Marshall
Publikováno v:
The Analyst. 146:3378-3390
Controlled-release formulations, in the form of micro- or nanoparticles, are increasingly attractive to the pharmaceutical industry for drug delivery. For respiratory illnesses, controlled-release microparticle formulations provide an opportunity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fe7abaa0ea71988b3ca3f2d4610faa
https://doi.org/10.1039/d0an02333g
https://doi.org/10.1039/d0an02333g
Autor:
Joe Coyle, Lee William Page, Dave Clapham, Karen Affleck, Paul N. Mortenson, Jonathan P. Hutchinson, Ashley Paul Hancock, Melanie Leveridge, Joelle Le, Heather Hobbs, David Norton, Rachel McMenamin, Simon Teague, Emma Sherriff, Linda J. Russell, Sorif Uddin, Caroline Richardson, Anne Cleasby, Simon Teanby Hodgson, Philip J. Day, Martyn Frederickson, Gordon Saxty
Publikováno v:
Med. Chem. Commun.. 5:134-141
Using X-ray crystallographic screening, fragments 4 and 6 were identified as inhibitors of hematopoietic prostaglandin D2 synthase (H-PGDS). Both fragments induced a small protein movement in the X-ray crystal structure relative to the apo structure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3850d001e5b02755bbbe21405c11b8
https://doi.org/10.1039/c3md00280b
https://doi.org/10.1039/c3md00280b
Publikováno v:
ADMET and DMPK
Volume 6
Issue 3
ADMET and DMPK, Vol 6, Iss 3, Pp 267-268 (2018)
Volume 6
Issue 3
ADMET and DMPK, Vol 6, Iss 3, Pp 267-268 (2018)
The authors of the original paper published with the same title: ADMET & DMPK 5(1) (2017) 14-38; doi: 10.5599/admet.5.1.373, apologize for the error in the plot on Figure 5. The erratum gives a correct plot.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0ef9ac1688af0f7fd088db136a1447
https://doi.org/10.5599/admet.568
https://doi.org/10.5599/admet.568
Autor:
Simon Teague, Klára Valkó
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 110
An alternative approach has been developed to estimate the clinical dose of new drug molecules at an early stage in the drug discovery process. This approach has been compared to traditional methods using the clinical dose as indicated on the drug la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494b33a45f6f188cb5fb378908c12e04
https://pubmed.ncbi.nlm.nih.gov/28215942
https://pubmed.ncbi.nlm.nih.gov/28215942
Autor:
Laurie J. Gordon, Gemma V. Puckey, Wyman Paul Adrian, David John Nash, Richard Blunt, Hugh J. Herdon, Simon Teague, Victoria Hadden, Stefano Fontana, Amanda Johns, Roderick A. Porter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6176-6179
A screening hit was used as the basis for the core structure of a new series of acylglycinamide GlyT-1 inhibitors. Investigation of the SAR around four areas of diversity used facile chemistry to prepare compounds quickly. By focussing on reducing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f8f89eeb234cf21b05ae54fe2cbc7a
https://doi.org/10.1016/j.bmcl.2011.07.096
https://doi.org/10.1016/j.bmcl.2011.07.096
Publikováno v:
ADMET and DMPK, Vol 5, Iss 1, Pp 14-38 (2017)
ADMET and DMPK
Volume 5
Issue 1
ADMET and DMPK
Volume 5
Issue 1
The drug discovery process can be accelerated by chromatographic profiling of the analogs to model in vivo distribution and the major non-specific binding. A balanced potency and chromatographically determined membrane and protein binding (IAM MB/PB)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc8a261b9b179948e988cd3ca72293c
https://doi.org/10.5599/admet.5.1.373
https://doi.org/10.5599/admet.5.1.373
Autor:
Simon Teague, Andrea M. Bradford, Mikhail Kalinichev, Roderick A. Porter, Hugh J. Herdon, Kathryn R. Starr
Publikováno v:
Brain research. 1331
Glycine can act as either an inhibitory neurotransmitter or as a potentiator of NMDA-dependent excitatory neurotransmission. There is some evidence that glycine can have both pro- and anticonvulsant properties in various rodent models of epilepsy. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5cda42306baf81f84a713d99b0d28b
https://pubmed.ncbi.nlm.nih.gov/20303337
https://pubmed.ncbi.nlm.nih.gov/20303337