Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Simon T. Nevin"'
Publikováno v:
Channels. 15:79-93
The voltage-gated sodium channel Nav1.8 mediates the tetrodotoxin-resistant (TTX-R) Na+ current in nociceptive primary sensory neurons, which has an important role in the transmission of painful st...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d00c455468c098540b72de6669282c3
https://doi.org/10.1080/19336950.2020.1860399
https://doi.org/10.1080/19336950.2020.1860399
Autor:
Richard J. Lewis, Marco Inserra, Simon T. Nevin, Paul F. Alewood, David J. Adams, Markus Muttenthaler
Publikováno v:
Aust J Chem
Australian Journal of Chemistry
Australian Journal of Chemistry
In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f6e826dec3d84dddb4e35b88c10013
https://doi.org/10.1071/ch19456
https://doi.org/10.1071/ch19456
Autor:
Richard J. Lewis, C-I Anderson Wang, Ron C Hogg, Paul F. Alewood, Simon T. Nevin, Gene Hopping, David J. Adams
Publikováno v:
Biochemical Pharmacology. 91:534-542
Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion channels involved in neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin [A10L]PnIA is a potent and selective antagonist of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b62e56990db39892519d4b3713fdc5d
https://doi.org/10.1016/j.bcp.2014.07.025
https://doi.org/10.1016/j.bcp.2014.07.025
Autor:
Taracad K. Venkatachalam, David C. Reutens, Damion H.R. Stimson, Simon T. Nevin, D. Maillet, A. R. King, Rajiv Bhalla, A. J. Pringle
Publikováno v:
Journal of radiological protection : official journal of the Society for Radiological Protection. 36(3)
The emphasis on the reduction of gaseous radioactive effluent associated with PET radiochemistry laboratories has increased. Various radioactive gas capture strategies have been employed historically including expensive automated compression systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3139ff51fe0e615c2c212b8e0e370e
https://pubmed.ncbi.nlm.nih.gov/27383139
https://pubmed.ncbi.nlm.nih.gov/27383139
Autor:
Takahiro Yasuda, Nicole Lawrence, Richard J. Lewis, Simon T. Nevin, David J. Adams, Oliver Knapp
Publikováno v:
British Journal of Pharmacology. 166:2148-2160
BACKGROUND AND PURPOSE Voltage-gated sodium channels are expressed primarily in excitable cells and play a pivotal role in the initiation and propagation of action potentials. Nine subtypes of the pore-forming α-subunit have been identified, each wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5656bf5e208cd64133d6a6fcfdbc0e5
https://doi.org/10.1111/j.1476-5381.2012.01955.x
https://doi.org/10.1111/j.1476-5381.2012.01955.x
Autor:
Brid P Callaghan, Christine A. Mozar, Harry Klimis, David J. Adams, Paul F. Alewood, Simon T. Nevin, Christopher W. Vaughan, MacDonald J. Christie
Publikováno v:
Pain. 152:259-266
α-Conotoxins that are thought to act as antagonists of nicotinic acetylcholine receptors (nAChRs) containing α3-subunits are efficacious in several preclinical models of chronic pain. Potent interactions of Vc1.1 with other targets have suggested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8474ce922dd1b01e01c97dfc7f1ee3
https://doi.org/10.1016/j.pain.2010.09.007
https://doi.org/10.1016/j.pain.2010.09.007
Autor:
Sunithi Gunasekera, David J. Craik, David J. Adams, Erica S. Lovelace, Anton A. Grishin, Charlotta Alvarmo, Richard J. Clark, Norelle L. Daly, Simon T. Nevin
Publikováno v:
Antioxidants & Redox Signaling. 14:87-95
α-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233c553e3eb7ae2dbc211a0a671adbef
https://doi.org/10.1089/ars.2009.3068
https://doi.org/10.1089/ars.2009.3068
Autor:
Richard J. Clark, Jonas Jensen, Simon T. Nevin, Brid P. Callaghan, David J. Adams, David J. Craik
Publikováno v:
Angewandte Chemie. 122:6695-6698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39544d399df924c1266e967bdfd41397
https://doi.org/10.1002/ange.201000620
https://doi.org/10.1002/ange.201000620
Publikováno v:
Biopolymers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1b1b8ad465354e5e7f5116ad219608
https://doi.org/10.1002/bip.21223
https://doi.org/10.1002/bip.21223
Autor:
Harry Klimis, Richard J. Clark, Simon T. Nevin, David J. Adams, MacDonald J. Christie, David J. Craik
Publikováno v:
Molecular Pharmacology. 72:1406-1410
The synthetic alpha-conotoxin Vc1.1 is a small disulfide bonded peptide currently in development as a treatment for neuropathic pain. Unlike Vc1.1, the native post-translationally modified peptide vc1a does not act as an analgesic in vivo in rat mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e6ce2c8b65f5f4b7b06e6d282dcc3b
https://doi.org/10.1124/mol.107.040568
https://doi.org/10.1124/mol.107.040568