Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Simon T. Nevin"'
Publikováno v:
Channels. 15:79-93
The voltage-gated sodium channel Nav1.8 mediates the tetrodotoxin-resistant (TTX-R) Na+ current in nociceptive primary sensory neurons, which has an important role in the transmission of painful st...
Autor:
Richard J. Lewis, Marco Inserra, Simon T. Nevin, Paul F. Alewood, David J. Adams, Markus Muttenthaler
Publikováno v:
Aust J Chem
Australian Journal of Chemistry
Australian Journal of Chemistry
In-solution conjugation is the most commonly used strategy to label peptides and proteins with fluorophores. However, lack of site-specific control and high costs of fluorophores are recognised limitations of this approach. Here, we established facil
Autor:
Richard J. Lewis, C-I Anderson Wang, Ron C Hogg, Paul F. Alewood, Simon T. Nevin, Gene Hopping, David J. Adams
Publikováno v:
Biochemical Pharmacology. 91:534-542
Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion channels involved in neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin [A10L]PnIA is a potent and selective antagonist of
Autor:
Taracad K. Venkatachalam, David C. Reutens, Damion H.R. Stimson, Simon T. Nevin, D. Maillet, A. R. King, Rajiv Bhalla, A. J. Pringle
Publikováno v:
Journal of radiological protection : official journal of the Society for Radiological Protection. 36(3)
The emphasis on the reduction of gaseous radioactive effluent associated with PET radiochemistry laboratories has increased. Various radioactive gas capture strategies have been employed historically including expensive automated compression systems.
Autor:
Takahiro Yasuda, Nicole Lawrence, Richard J. Lewis, Simon T. Nevin, David J. Adams, Oliver Knapp
Publikováno v:
British Journal of Pharmacology. 166:2148-2160
BACKGROUND AND PURPOSE Voltage-gated sodium channels are expressed primarily in excitable cells and play a pivotal role in the initiation and propagation of action potentials. Nine subtypes of the pore-forming α-subunit have been identified, each wi
Autor:
Brid P Callaghan, Christine A. Mozar, Harry Klimis, David J. Adams, Paul F. Alewood, Simon T. Nevin, Christopher W. Vaughan, MacDonald J. Christie
Publikováno v:
Pain. 152:259-266
α-Conotoxins that are thought to act as antagonists of nicotinic acetylcholine receptors (nAChRs) containing α3-subunits are efficacious in several preclinical models of chronic pain. Potent interactions of Vc1.1 with other targets have suggested t
Autor:
Sunithi Gunasekera, David J. Craik, David J. Adams, Erica S. Lovelace, Anton A. Grishin, Charlotta Alvarmo, Richard J. Clark, Norelle L. Daly, Simon T. Nevin
Publikováno v:
Antioxidants & Redox Signaling. 14:87-95
α-Conotoxins are peptides isolated from the venom ducts of cone snails that target nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential applications for treating a range of conditions in humans, incl
Autor:
Richard J. Clark, Jonas Jensen, Simon T. Nevin, Brid P. Callaghan, David J. Adams, David J. Craik
Publikováno v:
Angewandte Chemie. 122:6695-6698
Publikováno v:
Biopolymers
Autor:
Harry Klimis, Richard J. Clark, Simon T. Nevin, David J. Adams, MacDonald J. Christie, David J. Craik
Publikováno v:
Molecular Pharmacology. 72:1406-1410
The synthetic alpha-conotoxin Vc1.1 is a small disulfide bonded peptide currently in development as a treatment for neuropathic pain. Unlike Vc1.1, the native post-translationally modified peptide vc1a does not act as an analgesic in vivo in rat mode