Proteomics of lung tissue reveals differences in inflammation and alveolar-capillary barrier response between atelectasis and aerated regions

Autor: Azman Rashid, Congli Zeng, Gabriel Motta-Ribeiro, Simon T. Dillon, Towia A. Libermann, Marcos Adriano Lessa, Aranya Bagchi, John Hutchinson, Marcos F. Vidal Melo

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract Atelectasis is a frequent clinical condition, yet knowledge is limited and controversial on its biological contribution towards lung injury. We assessed the regional proteomics of atelectatic versus normally-aerated lung tissue to test the h

Externí odkaz: https://doaj.org/article/7113073f3170478dbbbd302611c0586a

Proteome-Wide Analysis Using SOMAscan Identifies and Validates Epidermal Growth Factor as a Disease Marker of Collagenous Gastritis

Autor: Debora Curci, Simon T. Dillon, Xuesong Gu, Harland Winter, Towia A. Libermann

Publikováno v: Gastro Hep Advances, Vol 1, Iss 5, Pp 689-702 (2022)

Background and Aims: Collagenous gastritis (CG) is a rare disorder characterized by increased subepithelial collagen deposition and inflammatory infiltrates. The mechanisms involved in CG pathogenesis are poorly understood, and no CG-associated bioma

Externí odkaz: https://doaj.org/article/d6cfdcd6a522474d91be86c86bad62c6

Targeted metabolomics analysis of postoperative delirium

Autor: Bridget A. Tripp, Simon T. Dillon, Min Yuan, John M. Asara, Sarinnapha M. Vasunilashorn, Tamara G. Fong, Eran D. Metzger, Sharon K. Inouye, Zhongcong Xie, Long H. Ngo, Edward R. Marcantonio, Towia A. Libermann, Hasan H. Otu

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Abstract Postoperative delirium is the most common complication among older adults undergoing major surgery. The pathophysiology of delirium is poorly understood, and no blood-based, predictive markers are available. We characterized the plasma metab

Externí odkaz: https://doaj.org/article/211d02c8977c44098e54809aa3d389c8

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

Autor: Tammy T. Hshieh, Sarinnapha M. Vasunilashorn, Madeline L. D'Aquila, Steven E. Arnold, Bradford C. Dickerson, Tamara G. Fong, Richard N. Jones, Edward R. Marcantonio, Eva M. Schmitt, Guoquan Xu, Yun Gou, Fan Chen, Lisa J. Kunze, Kamen V. Vlassakov, Ayesha R. Abdeen, Jeffrey K. Lange, Brandon E. Earp, Alexandra Touroutoglou, Becky C. Carlyle, Pia Kivisakk‐Webb, Thomas G. Travison, Simon T. Dillon, Towia A. Libermann, Sharon K. Inouye, RISE Study Group, Steven Arnold, Bradford Dickerson, Tamara Fong, Richard Jones, Thomas Travison, Michele Cavallari, Jacob Hooker, Tammy Hshieh, Savannah Kandigian, Long Ngo, Hasan Otu, Bianca Trombetta, Sarinnapha Vasunilashorn, Ayesha Abdeen, Douglas Ayres, Brandon Earp, Jeffrey Lange, Gregory Brick, Antonia Chen, Robert Davis, Jacob Drew, Richard Iorio, Fulton Kornack, Michael Weaver, Anthony Webber, Richard Wilk, Lisa Kunze, David Shaff, Kamen Vlassakov, Brett Armstrong, Angelee Banda, Sylvie Bertrand, Madeline D'Aquila, Jacqueline Gallagher, Baileigh Hightower, Shannon Malloy, Jacqueline Nee, Chloe Nobuhara, Abigail Overstreet, Annie Racine, David Urick, Grae Arabasz, Michael Brickhouse, Regan Butterfield, Shirley Hsu, Sara Makaretz, Judit Sore, Douglas Tommet, Sabrina Carretie, Ted Gruen, Katherine Tasker

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 752-762 (2019)

Abstract Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging. Methods This study invo

Externí odkaz: https://doaj.org/article/b778d4458ac14bf5af9509298ab701af

Exosome markers associated with immune activation and oxidative stress in HIV patients on antiretroviral therapy

Autor: Sukrutha Chettimada, David R. Lorenz, Vikas Misra, Simon T. Dillon, R. Keith Reeves, Cordelia Manickam, Susan Morgello, Gregory D. Kirk, Shruti H. Mehta, Dana Gabuzda

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)

Abstract Exosomes are nanovesicles released from most cell types including immune cells. Prior studies suggest exosomes play a role in HIV pathogenesis, but little is known about exosome cargo in relation to immune responses and oxidative stress. Her

Externí odkaz: https://doaj.org/article/b897ba8872bc48c9b7875ebc758d9ce5