Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Simon T Schäfer"'
1
Akademický článek
Increased circulating microRNA-122 is a biomarker for discrimination and risk stratification in patients defined by sepsis-3 criteria.
Autor: Tim Rahmel, Simon T Schäfer, Ulrich H Frey, Michael Adamzik, Jürgen Peters
Publikováno v: PLoS ONE, Vol 13, Iss 5, p e0197637 (2018)
BACKGROUND:Sepsis is now operationally defined as life-threatening organ dysfunction caused by an infection, identified by an acute change in SOFA-Score of at least two points, including clinical chemistry such as creatinine or bilirubin concentratio
Externí odkaz: https://doaj.org/article/e118a48e1d9646129e8b04b8d044ca7e
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2
Akademický článek
Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock.
Autor: Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104953 (2014)
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/del
Externí odkaz: https://doaj.org/article/7eab1cf054f94afc931c248e79a86408
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3
Akademický článek
Modified thromboelastometric tests provide improved sensitivity and specificity to direct oral anticoagulants compared to standard thromboelastometric tests in-vitro
Autor: Philipp Groene, Jennifer Butte, Sarah Thaler, Klaus Görlinger, Simon T. Schäfer
Publikováno v: Thrombosis Journal, Vol 20, Iss 1, Pp 1-9 (2022)
Abstract Background The detection of direct oral anticoagulants (DOACs) is still challenging but important in emergency patients. We recently demonstrated that modified thromboelastometry can detect rivaroxaban and dabigatran. Data on the detection r
Externí odkaz: https://doaj.org/article/1c5a4927474748179bdea16de4cb851f
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4
Akademický článek
Point-of-care detection and differentiation of anticoagulant therapy - development of thromboelastometry-guided decision-making support algorithms
Autor: Simon T. Schäfer, Anne-Christine Otto, Alice-Christin Acevedo, Klaus Görlinger, Steffen Massberg, Tobias Kammerer, Philipp Groene
Publikováno v: Thrombosis Journal, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background DOAC detection is challenging in emergency situations. Here, we demonstrated recently, that modified thromboelastometric tests can reliably detect and differentiate dabigatran and rivaroxaban. However, whether all DOACs can be det
Externí odkaz: https://doaj.org/article/f3a451000dba48f8be53e9001b9dcd02
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5
Akademický článek
Neutrophil extracellular trap formation and nuclease activity in septic patients
Autor: Linda E. Cox, Kai Walstein, Lena Völlger, Friederike Reuner, Alexandra Bick, Annika Dötsch, Andrea Engler, Jürgen Peters, Maren von Köckritz-Blickwede, Simon T. Schäfer
Publikováno v: BMC Anesthesiology, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background There is little knowledge, whether in patients with sepsis neutrophil extracellular trap (NET) formation and NET degrading nuclease activity are altered. Thus, we tested the hypotheses that 1) NET formation from neutrophils of sep
Externí odkaz: https://doaj.org/article/a9e95e84342c4822aab23297fcb152e2
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7
Point-of-care detection and differentiation of anticoagulant therapy - development of thromboelastometry-guided decision-making support algorithms
Autor: Philipp Groene, Steffen Massberg, Tobias Kammerer, Alice-Christin Acevedo, Anne-Christine Otto, Klaus Görlinger, Simon T. Schäfer
Publikováno v: Thrombosis Journal, Vol 19, Iss 1, Pp 1-11 (2021)
Thrombosis Journal
Background DOAC detection is challenging in emergency situations. Here, we demonstrated recently, that modified thromboelastometric tests can reliably detect and differentiate dabigatran and rivaroxaban. However, whether all DOACs can be detected and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6289ecba3840f2c0b1b3750496d61d9b
https://doaj.org/article/f3a451000dba48f8be53e9001b9dcd02
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9
Functional Testing for Tranexamic Acid Duration of Action Using Modified Viscoelastometry
Autor: Thomas Saller, Tobias Kammerer, Simon T. Schäfer, Sophia R. Sappel, Paula A. Sa, Sven Peterss, Patrick Scheiermann, Andreas Giebl, Christian Hagl, Philipp Groene
Publikováno v: Transfus Med Hemother
Introduction: Tranexamic acid (TXA) is the standard medication to prevent or treat hyperfibrinolysis. However, prolonged inhibition of lysis (so-called “fibrinolytic shutdown”) correlates with increased mortality. A new viscoelastometric test ena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60286caf0bd961cef5991220184b3ab
https://doi.org/10.1159/000511230
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10
Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery
Autor: Daniel Chappell, Tobias Nitschke, Alexander C. Paulus, Paula A. Sa, Simon T. Schäfer, Sophia R. Sappel, Philipp Groene, Thomas Saller
Publikováno v: Journal of Thrombosis and Thrombolysis. 51:989-996
Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and corr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b2ca57bef150f0387033a776ba81a7b
https://doi.org/10.1007/s11239-020-02272-8
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