Výsledky vyhledávání - "Simon Sydserff"

Postnatal epigenetic influences on seizure susceptibility in seizure-prone versus seizure-resistant rat strains

Autor: Andrea M. Patey, Krista L. Gilby, Simon Sydserff, Dan C. McIntyre, Jennifer Jans, Victoria Thorne, Veronique St-Onge

Publikováno v: Behavioral Neuroscience. 123:337-346

The creation of seizure-prone (Fast) and seizure-resistant (Slow) rat strains via selective breeding implies genetic control of relative seizure vulnerability, yet ample data also advocates an environmental contribution. To investigate potential envi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec8b2848e5ce569520c0461875c2aa2f
https://doi.org/10.1037/a0014730

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

Autor: A R Green, A R Borelli, Simon Sydserff, Alan J. Cross

Publikováno v: British Journal of Pharmacology. 135:103-112

The efficacy of the free radical trapping agent NXY-059 in reducing the infarct volume following both transient and permanent focal ischaemia has been examined in rats. In the transient ischaemia model, rats were subjected to a 2 h occlusion of the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c305fdc5c7618eeff0ec5d023df95148
https://doi.org/10.1038/sj.bjp.0704449

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Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition

Publikováno v: Journal of medicinal chemistry. 57(3)

A new series of potent and selective histamine-3 receptor (H3R) antagonists was identified on the basis of an azaspiro[2.5]octane carboxamide scaffold. Many scaffold modifications were largely tolerated, resulting in nanomolar-potent compounds in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69954ef50a32d3a1cdac6f8403f68ac6
https://pubmed.ncbi.nlm.nih.gov/24410637

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Long-Term Deficits Following Cerebral Hypoxia–Ischemia in Four-Week-Old Rats: Correspondence between Behavioral, Histological, and Magnetic Resonance Imaging Assessments

Autor: U.I. Tuor, Simon Sydserff, P. Kozlowski, Thomas J. Hudzik, M. R. Del Bigio, K. Malisza

Publikováno v: Experimental Neurology. 167:272-281

We examined whether following a hypoxic–ischemic insult in young animals there are long-lasting functional deficits that correlate either to histological tissue damage or to potential compensatory plasticity changes. Four-week-old rats were subject

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ae16682609e7314f11e56193ac420b
https://doi.org/10.1006/exnr.2000.7565

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Long-Term Functional End Points Following Middle Cerebral Artery Occlusion in the Rat

Autor: Gene C. Palmer, P Bialobok, P Gendron, Dan Widzowski, Simon Sydserff, Thomas J. Hudzik, Dale Corbett, A. R. Borrelli, J Miller, A Howell

Publikováno v: Pharmacology Biochemistry and Behavior. 65:553-562

The purpose of the present study was to assess the magnitude and stability of a number of functional deficits in rats subjected to occlusion of the middle cerebral artery (MCAO). Three groups of rats, treated with 90-min, 120-min, or sham occlusion w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82fd1c5492b994bb3500c6bce35a9a8
https://doi.org/10.1016/s0091-3057(99)00243-9

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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity

Herein, we describe the discovery of inhibitors of norepinephrine (NET) and dopamine (DAT) transporters with reduced activity relative to serotonin transporters (SERT). Two compounds, 8b and 21a, along with nomifensine were tested in a rodent recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03257ab664bd72a1d8bb75fec9134939
https://europepmc.org/articles/PMC4027539/

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Ultra-low exposure to α-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in α-7 receptor expression in rodents: implications for low dose clinical efficacy

Autor: Mark S. Eisman, Jennifer L. Werkheiser, Donna L. Maier, Min Ding, Simon Sydserff, A.J. Williams, Jeffrey S. Smith, S.J. Hubbs, D. Perry, Ladislav Mrzljak

Publikováno v: Neuroscience. 186

Αlpha-7 neuronal nicotinic receptors (NNRs) are considered targets for cognitive enhancement in schizophrenia and Alzheimer's disease. AZD0328 is an alpha-7 NNR partial agonist that enhances cognition in rodents and nonhuman primates at sub-microgra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307218f3cde123ff846cf96255a7db66
https://pubmed.ncbi.nlm.nih.gov/21550383

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Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes

Autor: E.J. Sutton, Dan Widzowski, Ladislav Mrzljak, Carla Maciag, James J. Doherty, Dekun Song, Chaoying Li, Yi Wang, Thomas J. Hudzik, Michael Quirk, Simon Sydserff, David Gurley, Jeffrey S. Smith, John C. Gordon, Gennady N. Smagin, Edwin C. Johnson, Tim Piser, Edward P. Christian, Gerald Jonak

Publikováno v: Biochemical pharmacology. 78(7)

AZD0328, a novel spirofuropyridine neuronal nicotinic receptor partial agonist, was used to investigate the role of alpha7 neuronal nicotinic receptor (NNR) activation in the modulation of midbrain dopamine neuron function, cortical dopamine release

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ee8a3e1b4629fbdf9688d4876f742a
https://pubmed.ncbi.nlm.nih.gov/19615981

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Differential neuroprotective effects for three GABA-potentiating compounds in a model of hypoxia-ischemia

Autor: Harold A. Robertson, K.L. Gilby, Simon Sydserff

Publikováno v: Brain research. 1035(2)

Clomethiazole (CMZ) is a GABA A -potentiating compound; however, it is unclear whether this mode of action is responsible for its neuroprotective effects in animal models of ischemia. This study compared the neuroprotective efficacies of muscimol and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0375c4b9fb1af899350e0c42db8af8f
https://pubmed.ncbi.nlm.nih.gov/15722059

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