Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simon Sumer"'
Autor:
Stefanie Schmitteckert, Anne Griesbeck, Simon Sumer, Anna Jauch, Alexandra Rolletschek, Beate Niesler, Gudrun A. Rappold, Sandra Hoffmann
Publikováno v:
Stem Cell Research, Vol 25, Iss C, Pp 278-282 (2017)
The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies.
Externí odkaz:
https://doaj.org/article/870431f5543e4ee19693b7d37f0a58b1
Autor:
Sandra Hoffmann, Stefanie Schmitteckert, Anne Griesbeck, Hannes Preiss, Simon Sumer, Alexandra Rolletschek, Martin Granzow, Volker Eckstein, Beate Niesler, Gudrun A. Rappold
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 51-57 (2017)
The homeodomain transcription factor Shox2 controls the development and function of the native cardiac pacemaker, the sinoatrial node (SAN). Moreover, SHOX2 mutations have been associated with cardiac arrhythmias in humans. For detailed examination o
Externí odkaz:
https://doaj.org/article/a23b23c64aac4637ad8f24d31b18b76b
Autor:
Kristin Raedecke, Karl-Ludwig Laugwitz, Johannes W.G. Janssen, Sebastian Clauss, Alessandra Moretti, Tatjana Dorn, Gudrun A. Rappold, Anna Jauch, Birgit Campbell, Svenja Laue, Simon Sumer, Sandra Hoffmann, Stefan Kääb, Viktoria Frajs
Publikováno v:
Stem Cell Reports
Summary Patient-specific human induced pluripotent stem cells (hiPSCs) offer unprecedented opportunities for the investigation of multigenic disease, personalized medicine, and stem cell therapy. For heterogeneous diseases such as atrial fibrillation
Autor:
Volker Eckstein, Hannes Preiss, Stefanie Schmitteckert, Anne Griesbeck, Beate Niesler, Simon Sumer, Sandra Hoffmann, Martin Granzow, Gudrun A. Rappold, Alexandra Rolletschek
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 51-57 (2017)
Stem cell research, 21, 51–57
Stem cell research, 21, 51–57
The homeodomain transcription factor Shox2 controls the development and function of the native cardiac pacemaker, the sinoatrial node (SAN).Moreover, SHOX2 mutations have been associatedwith cardiac arrhythmias in humans. For detailed examination of
Autor:
Roberto Fiore, Simon Sumer, Tatjana Wüst, Rainer K.W. Schwarting, Franziska Metge, Dominik Seffer, Markus Wöhr, Ayla Aksoy-Aksel, Silvia Bicker, Jeremy Valluy, Christoph Dieterich, Gerhard Schratt, Martin Lackinger
Publikováno v:
Nature neuroscience. 18(5)
The E3 ubiquitin ligase Ube3a is an important regulator of activity-dependent synapse development and plasticity. Ube3a mutations cause Angelman syndrome and have been associated with autism spectrum disorders (ASD). However, the biological significa
Autor:
Susanne Lucae, Gerhard Schratt, M.P. Schwarz, Adam Wright, Martin Hautzinger, Philip B. Mitchell, Sharof Khudayberdiev, Nicholas G. Martin, W. Maier, Johannes Schumacher, Piotr M. Czerski, Markus M. Nöthen, Janice M. Fullerton, Susanne Meier, Cristiana Cruceanu, Tim Becker, Jana Strohmaier, Peter R. Schofield, Stefan Herms, Guy A. Rouleau, André Lacour, Thomas G. Schulze, Sugirthan Sivalingam, Galina Pantelejeva, Gustavo Turecki, Elza Khusnutdinova, Lilia I. Abramova, Catherine Laprise, Fermín Mayoral, Stephanie H. Witt, Jens Treutlein, Joanna Hauser, James D. McKay, Sven Cichon, Martin Alda, Bertram Müller-Myhsok, Andreas Reif, Michael Bauer, Manuel Mattheisen, Franziska Degenhardt, Marcella Rietschel, Helmut Vedder, Peter Propping, Alexey Polonikov, Neonilia Szeszenia-Dabrowska, S. E. Medland, Scott D. Gordon, Markus Leber, Valery Krasnov, Lutz Priebe, Alexander Chuchalin, Susanne Moebus, Peter Hoffmann, Gulia Babadjanova, A Verhaert, Thomas W. Mühleisen, M Grigoroiu-Serbanescu, Jolanta Lissowska, Alexander S. Tiganov, Simon Sumer, Henning G. Schulz, Andreas Hofmann, Grant W. Montgomery, Paul Brennan, Anna Maaser, Andreas J. Forstner, Fabio Rivas, Manolis Kogevinas, Andrea Pfennig, Jutta Kammerer-Ciernioch, René Breuer
Publikováno v:
Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G & Nöthen, M M 2015, ' Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder ', Translational Psychiatry, vol. 5, pp. e678 . https://doi.org/10.1038/tp.2015.159
Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G & Nöthen, M M 2015, ' Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder ', Translational psychiatry, vol. 5, e678 . https://doi.org/10.1038/tp.2015.159
TRANSLATIONAL PSYCHIATRY
Translational Psychiatry
Translational Psychiatry 5(11), e678 (2015). doi:10.1038/tp.2015.159
Translational Psychiatry 5(11), e678-e678 (2015). doi:10.1038/tp.2015.159
Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G & Nöthen, M M 2015, ' Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder ', Translational psychiatry, vol. 5, e678 . https://doi.org/10.1038/tp.2015.159
TRANSLATIONAL PSYCHIATRY
Translational Psychiatry
Translational Psychiatry 5(11), e678 (2015). doi:10.1038/tp.2015.159
Translational Psychiatry 5(11), e678-e678 (2015). doi:10.1038/tp.2015.159
Bipolar disorder (BD) is a severe and highly heritable neuropsychiatric disorder with a lifetime prevalence of 1%. Molecular genetic studies have identified the first BD susceptibility genes. However, the disease pathways remain largely unknown. Accu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a9dfbe7d44fbe916aa460af53189e4
https://pure.au.dk/portal/da/publications/genomewide-analysis-implicates-micrornas-and-their-target-genes-in-the-development-of-bipolar-disorder(7d5dba96-d077-41ec-b2cc-08cdfdb3029c).html
https://pure.au.dk/portal/da/publications/genomewide-analysis-implicates-micrornas-and-their-target-genes-in-the-development-of-bipolar-disorder(7d5dba96-d077-41ec-b2cc-08cdfdb3029c).html
Autor:
Peter H. Störchel, Simon Sumer, Gabriele Siegel, Juliane Thümmler, Ayla Aksoy-Aksel, Federico Zampa, Gerhard Schratt
Publikováno v:
The EMBO journal. 34(17)
MicroRNAs (miRNAs) are important regulators of neuronal development, network connectivity, and synaptic plasticity. While many neuronal miRNAs were previously shown to modulate neuronal morphogenesis, little is known regarding the regulation of miRNA