Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Simon Spichak"'
Publikováno v:
npj Digital Medicine, Vol 6, Iss 1, Pp 1-4 (2023)
Abstract Large language models (LLMs) are being integrated into healthcare systems; but these models may recapitulate harmful, race-based medicine. The objective of this study is to assess whether four commercially available large language models (LL
Externí odkaz:
https://doaj.org/article/a8bcff9a84b84c23b42430629500f704
Autor:
Simon Spichak, Francisco Donoso, Gerard M. Moloney, Eoin Gunnigle, Jillian M. Brown, Martin Codagnone, Timothy G. Dinan, John F. Cryan
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 16, Iss , Pp 100318- (2021)
Recent investigations in neuroscience implicate the role of microbial-derived metabolites, such as short-chain fatty acids (SCFAs) in brain health and disease. The SCFAs acetate, propionate and butyrate have pleiotropic effects within the nervous sys
Externí odkaz:
https://doaj.org/article/9b5ed2419ea8470fbaff04de8ed62acd
Autor:
Paul D. Cotter, Patrick Fitzgerald, Fiona Crispie, Loreto Olavarría-Ramírez, Anna V. Golubeva, Marcus J. Claesson, Timothy G. Dinan, Rachel S. Fitzgerald, Marcel van de Wouw, Marcus Boehme, Caitlin S. M. Cowan, Evelyn Halitzki, Minal Jaggar, Enrique Morillas, Francisco Donoso, John F. Cryan, Gerard M. Moloney, Marzia Sichetti, Andreu Gual-Grau, Nathaniel L. Ritz, Simon Spichak, Katherine E. Guzzetta, Olivia F. O’Leary, Thomaz F.S. Bastiaanssen, Marta C Neto
Publikováno v:
Nature Aging. 1:666-676
The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfaeebc2a5b3434183e7b66d4313234
https://doi.org/10.1038/s43587-021-00093-9
https://doi.org/10.1038/s43587-021-00093-9
Autor:
Katherine E. Guzzetta, Olivia F. O’Leary, John F. Cryan, Gerard Clarke, Timothy G. Dinan, Simon Spichak
Publikováno v:
Drug Discovery Today: Disease Models. 28:79-93
The human body harbors trillions of commensal microbes which play a crucial role in host development of the immune system, gastrointestinal tract, and brain. An alteration in the composition or function of these microbes has been implicated in numero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7128832a99f20f39e5de59c19772656
https://doi.org/10.1016/j.ddmod.2019.08.002
https://doi.org/10.1016/j.ddmod.2019.08.002
Autor:
Donald J. Mabbott, Alexandra Decker, Simon Spichak, Stephanie Ameis, Adeoye Oyefiade, Jaleel Jefferson, Jason P. Lerch, Nadia Scantlebury, Conrad Rockel, Kamila U. Szulc
Publikováno v:
Human Brain Mapping. 39:204-217
Neural communication is facilitated by intricate networks of white matter (WM) comprised of both long and short range connections. The maturation of long range WM connections has been extensively characterized, with projection, commissural, and assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8e931e7c7b17a847111c64e7ba30ea
https://doi.org/10.1002/hbm.23836
https://doi.org/10.1002/hbm.23836
Autor:
Kenneth J. O’Riordan, Anna V. Golubeva, Enrique Morillas, Timothy G. Dinan, Alicia Molinero-Perez, Sofia Cussotto, Martín Gabriel Codagnone, Rory C. O'Connor, Veronica L. Peterson, Emanuela Morelli, Thomaz F.S. Bastiaanssen, Christine Fülling, Kiran V. Sandhu, Joana S Cruz-Pereira, Ana Paula Ventura-Silva, Shauna E. Wallace-Fitzsimons, Caitlin S. M. Cowan, Emily M. Teichman, Katherine E. Guzzetta, Niall P. Hyland, Gerard Clarke, Marcus Boehme, Minal Jaggar, John F. Cryan, Caitriona M. Long-Smith, Nathaniel L. Ritz, Simon Spichak, Jason A. Martin, Joshua M. Lyte, Kieran Rea, Gerard M. Moloney, Eoin Sherwin, Marcel van de Wouw
Publikováno v:
Physiological Reviews
The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c5dfe9021ca88f75f48d71043bba4f
https://pubmed.ncbi.nlm.nih.gov/31460832
https://pubmed.ncbi.nlm.nih.gov/31460832
Publikováno v:
Frontiers in neuroendocrinology. 56
Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e9523a736dba55ec7f3914501fd73e
https://pubmed.ncbi.nlm.nih.gov/31805290
https://pubmed.ncbi.nlm.nih.gov/31805290
How does the immune system impact brain development? The exciting and somewhat unexpected relationship between the immune system and the brain has become one of the most fascinating topics in neuroscience. Even though the immune system was initially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53b69b8ec740afc979aa7e07abf8542
https://hdl.handle.net/10468/9362
https://hdl.handle.net/10468/9362
