Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon Schwager"'
Autor:
Carlotta Tacconi, Catharina D. Commerford, Lothar C. Dieterich, Simon Schwager, Yuliang He, Kristian Ikenberg, Ekaterina Friebel, Burkhard Becher, Sònia Tugues, Michael Detmar
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108993- (2021)
Summary: Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macro
Externí odkaz:
https://doaj.org/article/4e2181013db14da88a64ec33d0ad2f5a
Autor:
William T. Ralvenius, Elena Neumann, Martina Pagani, Mario A. Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Chronic itch affects about 10% of the general population, however current treatments are largely ineffective. Here, the authors show that targeting of inhibitory α2 and α3GABAA receptors reduces itch in mice and in a canine model, suggesting this a
Externí odkaz:
https://doaj.org/article/8993328b421e431ca678a24d0b1b96fb
Autor:
Simon Schwager, Michael Detmar
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and disp
Externí odkaz:
https://doaj.org/article/00c2589c7a1147f4bfcb6f4667df72ac
Autor:
Lothar C. Dieterich, Carlotta Tacconi, Catharina D. Commerford, Simon Schwager, Burkhard Becher, Sonia Tugues, Ekaterina Friebel, Kristian Ikenberg, Michael Detmar, Yuliang He
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108993-(2021)
Cell Reports, 35 (2)
Cell Reports, 35 (2)
Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169+ macrophages as the predominant macrophage sub
Autor:
Carlotta, Tacconi, Catharina D, Commerford, Lothar C, Dieterich, Simon, Schwager, Yuliang, He, Kristian, Ikenberg, Ekaterina, Friebel, Burkhard, Becher, Sònia, Tugues, Michael, Detmar
Publikováno v:
Cell reports. 35(2)
Although the contribution of macrophages to metastasis is widely studied in primary tumors, the involvement of macrophages in tumor-draining lymph nodes (LNs) in this process is less clear. We find CD169
Autor:
Susanna Poghosyan, Giorgia Vella, Samia B. Bachmann, Michael Detmar, Jay W. Shin, Simon Schwager, Sun Young Yoon, Cédric Poyet, Sinem Karaman, Vivianne I. Otto, Filip Roudnicky
Publikováno v:
Oncogene
ResearcherID
Oncogene, 37 (19)
ResearcherID
Oncogene, 37 (19)
Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis. Tumor-associated blood vascular endothelial cells (BECs) were isolated from human invasive bladder cancers and from matched normal bladde
Autor:
Dario Neri, Carlotta Tacconi, Davor Bajic, Nikola Cousin, Marko Sesartic, Michael Detmar, Simon Schwager, John P. Sundberg
Publikováno v:
ACS Pharmacol Transl Sci
ACS Pharmacology and Translational Science, 2 (5)
ACS Pharmacology and Translational Science, 2 (5)
Copyright © 2019 American Chemical Society. Crohn's disease (CD) and ulcerative colitis (UC) are two distinct forms of inflammatory bowel disease (IBD) characterized by an expanded lymphatic network with impaired functionality both in mouse models a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c63c21aca06b95c578f378d2412c452
https://europepmc.org/articles/PMC7088901/
https://europepmc.org/articles/PMC7088901/
Autor:
Steven T. Proulx, Alexandra Michaela Golding-Ochsenbein, Michael Detmar, Cornelia Halin, Philipp Probst, Roman Fetz, Dario Neri, Teresa Hemmerle, Sinem Karaman, Silvana Renner, Simon Schwager
Publikováno v:
JCI Insight
JCI Insight, 3 (23)
JCI Insight, 3 (23)
VEGF-C is an important mediator of lymphangiogenesis and has been shown to alleviate chronic inflammation in a variety of disease models. In this study, we investigated whether targeted delivery of VEGF-C to sites of inflammation and site-specific ac
Autor:
Cornelia Halin, Simon Schwager, Steven T. Proulx, Dario Neri, Teresa Hemmerle, S. Zgraggen, Michael Detmar
Publikováno v:
Journal of Investigative Dermatology. 138:S159
Autor:
Mikael Maksimow, Ailsa J. Christiansen, Sirpa Jalkanen, Maija Hollmén, Zsuzsanna Varga, Sinem Karaman, Michael Detmar, Angela Lisibach, Simon Schwager
Publikováno v:
Oncoimmunology
OncoImmunology
OncoImmunology
Tumor-associated macrophages (TAMs) have been implicated in the promotion of breast cancer growth and metastasis, and a strong infiltration by TAMs has been associated with estrogen receptor (ER)-negative tumors and poor prognosis. However, the molec