Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multiparametric mapping (MPM)

Autor: Simon Schading, Maryam Seif, Tobias Leutritz, Markus Hupp, Armin Curt, Nikolaus Weiskopf, Patrick Freund

Publikováno v: NeuroImage, Vol 271, Iss , Pp 120046- (2023)

Short MRI acquisition time, high signal-to-noise ratio, and high reliability are crucial for image quality when scanning healthy volunteers and patients. Cross-sectional cervical cord area (CSA) has been suggested as a marker of neurodegeneration and

Externí odkaz: https://doaj.org/article/cdf43f77a0b948dd8b9507ce60a27ab4

Reliability of multi-parameter mapping (MPM) in the cervical cord: A multi-center multi-vendor quantitative MRI study

Autor: Maryam Seif, Tobias Leutritz, Simon Schading, Tim Emmengger, Armin Curt, Nikolaus Weiskopf, Patrick Freund

Publikováno v: NeuroImage, Vol 264, Iss , Pp 119751- (2022)

MRI based multicenter studies which target neurological pathologies affecting the spinal cord and brain – including spinal cord injury (SCI) – require standardized acquisition protocols and image processing methods. We have optimized and applied

Externí odkaz: https://doaj.org/article/eb10cd86697c466b886945f79aed9bfb

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Autor: Emilio Yángüez, Annika Hunziker, Maria Pamela Dobay, Soner Yildiz, Simon Schading, Elizaveta Elshina, Umut Karakus, Peter Gehrig, Jonas Grossmann, Ronald Dijkman, Mirco Schmolke, Silke Stertz

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Influenza A virus (IAV) causes annual epidemics and development of antivirals is needed. Here, the authors perform phosphoproteomics during IAV entry and identify GRK2 as drug target, inhibition of which decreases replication of seasonal and pandemic

Externí odkaz: https://doaj.org/article/75fc5e0fffec45b99c4b42c17dc10447

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target

Autor: Peter Gehrig, Simon Schading, Maria Pamela Dobay, Ronald Dijkman, Jonas Grossmann, Elizaveta Elshina, Silke Stertz, Umut Karakus, Annika Hunziker, Emilio Yángüez, Mirco Schmolke, Soner Yildiz

Publikováno v: Nature Communications
Yángüez, Emilio; Hunziker, Annika; Dobay, Maria Pamela; Yildiz, Soner; Schading, Simon; Elshina, Elizaveta; Karakus, Umut; Gehrig, Peter; Grossmann, Jonas; Dijkman, Ronald; Schmolke, Mirco; Stertz, Silke (2018). Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target. Nature communications, 9(1), p. 3679. Nature Publishing Group 10.1038/s41467-018-06119-y
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 9
Nature Communications, Vol. 9, No 1 (2018) P. 3679

Although annual influenza epidemics affect around 10% of the global population, current treatment options are limited and development of new antivirals is needed. Here, using quantitative phosphoproteomics, we reveal the unique phosphoproteome dynami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7063fe1382065e49e27833e3a8b04875
https://pubmed.ncbi.nlm.nih.gov/30206219