Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Simon S. McDade"'
Autor:
Tamas Sessler, Gerard P. Quinn, Mark Wappett, Emily Rogan, David Sharkey, Baharak Ahmaderaghi, Mark Lawler, Daniel B. Longley, Simon S. McDade
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Kaplan–Meier (KM) survival analyses based on complex patient categorization due to the burgeoning volumes of genomic, molecular and phenotypic data, are an increasingly important aspect of the biomedical researcher’s toolkit. Commercial
Externí odkaz:
https://doaj.org/article/cfca7324fc9a45e0aa3aa715d09fa8ec
Autor:
Ivana Steiner, Teresita del N.J. Flores-Tellez, Renaud Mevel, Amin Ali, Pengbo Wang, Pieta Schofield, Caron Behan, Nicholas Forsythe, Garry Ashton, Catherine Taylor, Ian G. Mills, Pedro Oliveira, Simon S. McDade, Dietmar M. Zaiss, Ananya Choudhury, Georges Lacaud, Esther Baena
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112377- (2023)
Summary: The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen deprivation and ex
Externí odkaz:
https://doaj.org/article/ea2b525372434ee5b0059bdaa9e2fe69
Autor:
Gerard P. Quinn, Tamas Sessler, Baharak Ahmaderaghi, Shauna Lambe, Harper VanSteenhouse, Mark Lawler, Mark Wappett, Bruce Seligmann, Daniel B. Longley, Simon S. McDade
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Transcriptionally informed predictions are increasingly important for sub-typing cancer patients, understanding underlying biology and to inform novel treatment strategies. For instance, colorectal cancers (CRCs) can be classified
Externí odkaz:
https://doaj.org/article/c0829fc0ca034492a1c3d272aaaac828
Autor:
Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)
Abstract Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disrup
Externí odkaz:
https://doaj.org/article/3fd851ad37fa451687518ec09ff3247a
Autor:
Baharak Ahmaderaghi, Raheleh Amirkhah, James Jackson, Tamsin R. M. Lannagan, Kathryn Gilroy, Sudhir B. Malla, Keara L. Redmond, Gerard Quinn, Simon S. McDade, ACRCelerate Consortium, Tim Maughan, Simon Leedham, Andrew S. D. Campbell, Owen J. Sansom, Mark Lawler, Philip D. Dunne
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
Generation of transcriptional data has dramatically increased in the past decade, driving the development of analytical algorithms that enable interrogation of the biology underpinning the profiled samples. However, these resources require users to h
Externí odkaz:
https://doaj.org/article/af0348220b314b64a6a61c4ef7c86992
Autor:
James S. Smith, Katrina M. Lappin, Stephanie G. Craig, Fabio G. Liberante, Clare M. Crean, Simon S. McDade, Alexander Thompson, Ken I. Mills, Kienan I. Savage
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-18 (2020)
Abstract Background The cohesin complex plays a major role in folding the human genome into 3D structural domains. Mutations in members of the cohesin complex are known early drivers of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML
Externí odkaz:
https://doaj.org/article/3da9f9f6b1b142149744239d66e7c7a9
Autor:
Kirsty Taylor, Jinfeng Zou, Marcos Magalhaes, Marc Oliva, Anna Spreafico, Aaron R. Hansen, Simon S. McDade, Vicky M. Coyle, Mark Lawler, Elena Elimova, Scott V. Bratman, Lillian L. Siu
Publikováno v:
European Journal of Cancer. 188:29-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::524b120de6e23ddab341261e886261b4
https://doi.org/10.1016/j.ejca.2023.04.014
https://doi.org/10.1016/j.ejca.2023.04.014
Publikováno v:
eLife, Vol 9 (2020)
The transcription factor p53 is the best-known tumor suppressor, but its sibling p63 is a master regulator of epidermis development and a key oncogenic driver in squamous cell carcinomas (SCC). Despite multiple gene expression studies becoming availa
Externí odkaz:
https://doaj.org/article/e246dbc3246341ba89c8ddc029aa231c
Autor:
Philip D. Dunne, Matthew Alderdice, Paul G. O'Reilly, Aideen C. Roddy, Amy M. B. McCorry, Susan Richman, Tim Maughan, Simon S. McDade, Patrick G. Johnston, Daniel B. Longley, Elaine Kay, Darragh G. McArt, Mark Lawler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Tumour expression profiling is currently used for prognostic and predictive purposes without taking into account the intra patient heterogeneity. Here the authors show that cancer cell specific signatures overcome the tumour heterogeneity effect and
Externí odkaz:
https://doaj.org/article/4cfe33bfecaf449b9233c78e1aecfd67
Autor:
Sandra Van Schaeybroeck, Sarah Ross, Melissa J. LaBonte, Chris Winnington, Jose Sousa, Jochen H.M. Prehn, Andreas U. Lindner, Manisha Maurya, Shauna Lambe, Christopher J. Scott, Simon S. McDade, Frederica Di Nicolantonio, Alberto Bardelli, Lyndsey Hanson, Daryl Griffin, Mustasin Rassel, Cheryl H. Latimer, Rebecca Briggs, Hajrah Khawaja
concentrations of drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::775d1337fd04e2390f5c609136da2ed2
https://doi.org/10.1158/1535-7163.22523058
https://doi.org/10.1158/1535-7163.22523058
