Výsledky vyhledávání - "Simon Roussel"

Two-kidney one-clip is a pertinent approach to integrate arterial hypertension in animal models of stroke: Serial magnetic resonance imaging studies of brain lesions before and during cerebral ischemia

Autor: Omar Touzani, Benjamin Ménard, Laurent Chazalviel, Myriam Bernaudin, Simon Roussel

Publikováno v: Journal of Cerebral Blood Flow and Metabolism
Journal of Cerebral Blood Flow and Metabolism, 2017, 38 (10), pp.1769-1780. ⟨10.1177/0271678X17715813⟩
Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2017, 38 (10), pp.1769-1780. ⟨10.1177/0271678X17715813⟩

Although chronic arterial hypertension (CAH) represents the major comorbid factor in stroke, it is rarely integrated in preclinical studies of stroke. The majority of those investigations employ spontaneously hypertensive rats (SHR) which display a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc54cd0ff9a51688da90f13797c8ff5
https://doi.org/10.1177/0271678x17715813

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Silencing erythropoietin receptor on glioma cells reinforces efficacy of temozolomide and X-rays through senescence and mitotic catastrophe

Autor: Simon Roussel, Aurélie N. Gérault, Jean-Sébastien Guillamo, Didier Divoux, Samuel Valable, Jérôme Toutain, Edwige Petit, Elodie A. Pérès, Marc Sanson, Myriam Bernaudin

Publikováno v: ResearcherID
Oncotarget
Oncotarget, 2015, 6 (4), pp.2101-19. ⟨10.18632/oncotarget.2937⟩
Oncotarget, Impact journals, 2015, 6 (4), pp.2101-19. ⟨10.18632/oncotarget.2937⟩

Hypoxia-inducible genes may contribute to therapy resistance in glioblastoma (GBM), the most aggressive and hypoxic brain tumours. It has been recently reported that erythropoietin (EPO) and its receptor (EPOR) are involved in glioma growth. We now i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61e7fe2fb756e484b258943d4583d38
https://doi.org/10.18632/oncotarget.2937

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Targeting the erythropoietin receptor on glioma cells reduces tumour growth

Autor: Simon Roussel, Léna Marteau, Edwige Petit, Myriam Bernaudin, Jean-François Bernaudin, Jean-Sébastien Guillamo, Emmanuèle Lechapt-Zalcman, Elodie A. Pérès, Samuel Valable

Publikováno v: Experimental Cell Research. 317:2321-2332

Hypoxia has been shown to be one of the major events involved in EPO expression. Accordingly, EPO might be expressed by cerebral neoplastic cells, especially in glioblastoma, known to be highly hypoxic tumours. The expression of EPOR has been describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc1e1e8db93147380582a4c9f7c3680
https://doi.org/10.1016/j.yexcr.2011.06.011

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Diffusion Tensor MRI Reveals Chronic Alterations in White Matter Despite the Absence of a Visible Ischemic Lesion on Conventional MRI

Autor: Ebeline Bihel, Omar Touzani, Jérôme Toutain, Simon Roussel, Myriam Bernaudin

Publikováno v: Stroke. 42:1412-1419

Background and Purpose— The impact of stroke on white matter is poorly described in preclinical investigations mainly based on rodents with a low white (WM)/gray matter ratio. Using diffusion tensor imaging, we evaluated WM alterations and correlat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3ed9fcd02e4d45f30923b7dba43466
https://doi.org/10.1161/strokeaha.110.596650

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Detection and quantification of remote microglial activation in rodent models of focal ischaemia using the TSPO radioligand CLINDE

Autor: Didier Divoux, Sylvie Bodard, Edwige Petit, Sylvie Chalon, Myriam Bernaudin, Simon Roussel, Jérôme Toutain, Denis Guilloteau, Nicolas Arlicot, Andrew Katsifis

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 37:2371-2380

Neuroinflammation is involved in stroke pathophysiology and might be imaged using radioligands targeting the 18 kDa translocator protein (TSPO). We studied microglial reaction in brain areas remote from the primary lesion site in two rodent models of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c40614ad0ead19c02af7b190f321d5
https://doi.org/10.1007/s00259-010-1598-7

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Impact of Genetic and Renovascular Chronic Arterial Hypertension on the Acute Spatiotemporal Evolution of the Ischemic Penumbra: A Sequential Study with MRI in the Rat

Autor: Omar Touzani, Jérôme Toutain, Annelise Letourneur, Myriam Bernaudin, Simon Roussel

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 31:504-513

Although chronic arterial hypertension (CAH) increases the risk of stroke and the severity of the resultant lesion, it is rarely integrated in preclinical studies. Here, we analyzed the impact of CAH on the acute spatiotemporal evolution of the ische

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2c1ec32e7dca57b32e37cab5f8a17c
https://doi.org/10.1038/jcbfm.2010.118

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Permanent or Transient Chronic Ischemic Stroke in the Non-Human Primate: Behavioral, Neuroimaging, Histological, and Immunohistochemical Investigations

Autor: Omar Touzani, Jérôme Toutain, Annelise Letourneur, Ricardo Insausti, Palma Pro-Sistiaga, Ebeline Bihel, Simon Roussel, Myriam Bernaudin, Romaric Saulnier

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 30:273-285

Using multimodal magnetic resonance imaging (MRI), behavioral, and immunohistochemical analyses, we examined pathological changes at the acute, sub-acute, and chronic stages, induced by permanent or temporary ischemia in the common marmoset. Animals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5126d155a2759871032a60675c045735
https://doi.org/10.1038/jcbfm.2009.209

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Chronic arterial hypertension impedes glioma growth: a multiparametric MRI study in the rat

Autor: Eric T. MacKenzie, Omar Touzani, Fabien Fillesoye, Annelise Letourneur, Jérôme Toutain, Edwige Petit, Myriam Bernaudin, Samuel Valable, Simon Roussel

Publikováno v: Hypertension Research
Hypertension Research, 2015, 38 ((11)), pp.723-32. ⟨10.1038/hr.2015.66⟩
Hypertension Research, Nature Publishing Group, 2015, 38 ((11)), pp.723-32. 〈10.1038/hr.2015.66〉
Hypertension Research, Nature Publishing Group, 2015, 38 ((11)), pp.723-32. ⟨10.1038/hr.2015.66⟩

International audience; Glioblastoma is the most aggressive brain tumor and is almost always fatal. These tumors are highly vascularized and angiogenesis is one of the pre-eminent mechanisms underlying their growth. Chronic arterial hypertension (CAH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53935ecddc010fcd1d330a158faea59c
https://hal.science/hal-01587404

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