Výsledky vyhledávání - "Simon Rosenfeld"

From Faulty Biochemical Assumptions to Poor Diagnostic Performance: Reflections on the Failure of DNA Microarrays to Become a Reliable Clinical Diagnostic Tool

Autor: Simon Rosenfeld

Publikováno v: British Journal of Medicine and Medical Research. 4:4511-4522

Since their inception about two decades ago, DNA microarrays have been considered as a great hope in translational research and personalized medicine. Although DNA microarrays for gene expression profiling proved to be an indispensable tool in the la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bc9d6d29414a95a48d378c2e719301e
https://doi.org/10.9734/bjmmr/2014/9661

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The emerging medical ecology of the human gut microbiome

Autor: Simon Rosenfeld, John W. Pepper

Publikováno v: Trends in Ecology & Evolution. 27:381-384

It is increasingly clear that the human gut microbiome has great medical importance, and researchers are beginning to investigate its basic biology and to appreciate the challenges that it presents to medical science. Several striking new empirical r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd5aa33941bd80d5d25075c81cdb195
https://doi.org/10.1016/j.tree.2012.03.002

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Critical Self-Organized Self-Sustained Oscillations in Large Regulatory Networks: Towards Understanding the Gene Expression Initiation

Autor: Simon Rosenfeld

Publikováno v: Gene Regulation and Systems Biology, Vol 2011, Iss 5, Pp 27-40 (2011)
Gene Regulation and Systems Biology
Gene Regulation and Systems Biology, Vol 5 (2011)

In this paper, a new model of self-organized criticality is introduced. This model, called the gene expression paradigm, is motivated by the problem of gene expression initiation in the newly-born daughter cells after mitosis. The model is fundamenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15d82cb9a557bb33237093f198d97ef
http://www.la-press.com/critical-self-organized-self-sustained-oscillations-in-large-regulator-a2554

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Patterns of Stochastic Behavior in Dynamically Unstable High-Dimensional Biochemical Networks

Autor: Simon Rosenfeld

Publikováno v: Gene Regulation and Systems Biology, Vol 3, Pp 1-10 (2009)
Gene Regulation and Systems Biology, Vol 2009, Iss 3, Pp 1-10 (2009)
Gene Regulation and Systems Biology
Gene Regulation and Systems Biology, Vol 3 (2009)

The question of dynamical stability and stochastic behavior of large biochemical networks is discussed. It is argued that stringent conditions of asymptotic stability have very little chance to materialize in a multidimensional system described by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62aac54c66f3771fd9a9ee833238b0
http://www.la-press.com/patterns-of-stochastic-behavior-in-dynamically-unstable-high-dimension-a1300

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Origins of Stochasticity and Burstiness in High-Dimensional Biochemical Networks

Autor: Simon Rosenfeld

Publikováno v: EURASIP Journal on Bioinformatics and Systems Biology

Two major approaches are known in the field of stochastic dynamics of intracellular biochemical networks. The first one places the focus of attention on the fact that many biochemical constituents vitally important for the network functionality may b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8eacc6cc35fc811799d75a780578351
https://doi.org/10.1155/2009/362309

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Approximate bivariate gamma generator with prespecified correlation and different marginal shapes

Autor: Simon Rosenfeld

Publikováno v: ACM Transactions on Modeling and Computer Simulation. 18:1-20

A new algorithm is proposed for generating approximate bivariate gamma random samples with a prespecified correlation coefficient and different marginal shapes. A distinctive feature of this approach is computational simplicity and ease of control. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::210f0d9e21d19a02bff9f41ff80d57dc
https://doi.org/10.1145/1391978.1391982

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Stochastic cooperativity in non-linear dynamics of genetic regulatory networks

Autor: Simon Rosenfeld

Publikováno v: Mathematical Biosciences. 210:121-142

Two major approaches are known in the field of stochastic dynamics of genetic regulatory networks (GRN). The first one, referred here to as the Markov Process Paradigm (MPP), places the focus of attention on the fact that many biochemical constituent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4138baa26aeae480270bb8d45a9db5b8
https://doi.org/10.1016/j.mbs.2007.05.006

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Applications of comprehensive cancer progression models in the fight against cancer

Autor: Asad Umar, Sam Thiagalingam, Simon Rosenfeld

Publikováno v: Systems Biology of Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9195d032dd21c9dfa5698ea73d8a175
https://doi.org/10.1017/cbo9780511979811.030

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Critical Junction: Nonlinear Dynamics, Swarm Intelligence and Cancer Research

Autor: Simon Rosenfeld

Publikováno v: CIBCB

Complex biological systems manifest a large variety of emergent phenomena among which prominent roles belong to self-organization and swarm intelligence. Despite astoundingly wide repertoire of observed forms, there are comparatively simple rules gov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643a0a0ceb5c1c4706064a1dea30f26f
https://doi.org/10.15761/fgnamb.1000103

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