Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Simon R. Smukler"'
Autor:
Sarah Abdullah, Simon R. Smukler, Hamed S. Najafabadi, Derek van der Kooy, Margot Arntfield, Rozita Razavi
Publikováno v:
Diabetes. 64:1311-1323
Endogenous pancreatic multipotent progenitors (PMPs) are ideal candidates for regenerative approaches to compensate for β-cell loss since their β-cell–producing capacities as well as strategic location would eliminate unnecessary invasive manipul
Publikováno v:
International Journal of Audiology. 54:984-986
To determine the prevalence of hearing protection use among attendees of Rock and Roll concerts at baseline and in concerts where earplugs are provided for free at concert venue entrances.Six concerts performed at two music venues in Toronto, Canada
Autor:
Raewyn M. Seaberg, Derek van der Kooy, Rosemary Ahrens, Feihan Dai, Paul E. Fraser, Simon R. Smukler, Rozita Razavi, Phillip Karpowicz, Margot Arntfield, Simon Ming-Yuen Lee, Michael B. Wheeler, George Bikopoulos
Publikováno v:
Biological Sciences Publications
Summary The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived multipotent precursor (PMP) cells in the mouse with the intriguing capacity to generate prog
Publikováno v:
Developmental Biology. 278(1):71-85
Recent reports of stem cell plasticity have led to the suggestion that there are few intrinsic differences between precursor cells, and that environment dictates fundamental cellular properties such as differentiation potential. This suggestion has b
Autor:
Fang Cai, Lulzim Shkreta, Denise D. Belsham, Hong Cui, Anne Marie F. Salapatek, Simon R. Smukler
Publikováno v:
Endocrinology. 145:393-400
Knowledge of how the brain achieves its diverse central control of basic physiology is severely limited by the virtual absence of appropriate cell models. Isolation of clonal populations of unique peptidergic neurons from the hypothalamus will facili
Exogenous Nitric Oxide and Endogenous Glucose-Stimulated β-Cell Nitric Oxide Augment Insulin Release
Publikováno v:
Diabetes. 51:3450-3460
The role nitric oxide (NO) plays in physiological insulin secretion has been controversial. Here we present evidence that exogenous NO stimulates insulin secretion, and that endogenous NO production occurs and is involved in the regulation of insulin
Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
Publikováno v:
The Journal of Cell Biology
The mechanisms governing the emergence of the earliest mammalian neural cells during development remain incompletely characterized. A default mechanism has been suggested to underlie neural fate acquisition; however, an instructive process has also b
Autor:
Raewyn M. Seaberg, Grigori Enikolopov, Michael B. Wheeler, Zeenat Asghar, Simon R. Smukler, Derek van der Kooy, Gregory S. Korbutt, Timothy J. Kieffer
Publikováno v:
Nature biotechnology. 22(9)
The clonal isolation of putative adult pancreatic precursors has been an elusive goal of researchers seeking to develop cell replacement strategies for diabetes. We report the clonal identification of multipotent precursor cells from the adult mouse
Autor:
Sabine Sewing, Jing Wang, Catherine B. Chan, Patrick E. MacDonald, Anne Marie F. Salapatek, George Sakellaropoulos, Simon R. Smukler, Jamie W. Joseph, Michael B. Wheeler, Robert G. Tsushima, Monique C. Saleh, Jianli Wang
Publikováno v:
The Journal of biological chemistry. 277(47)
Voltage-dependent (Kv) outward K(+) currents repolarize beta-cell action potentials during a glucose stimulus to limit Ca(2+) entry and insulin secretion. Dominant-negative "knockout" of Kv2 family channels enhances glucose-stimulated insulin secreti
Autor:
Xiao Fang Ha, Simon R. Smukler, Herbert Y. Gaisano, Patrick E. MacDonald, Jing Wang, Michael B. Wheeler, Peter H. Backx, Ann Marie F. Salapatek, Anthony M. Sun
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 15(8)
In pancreatic β-cells, voltage-dependent K+ (Kv) channels are potential mediators of repolarization, closure of Ca2+ channels, and limitation of insulin secretion. The specific Kv channels expressed in β-cells and their contribution to the delayed