Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Simon R. Levinson"'
Autor:
Noa Liscovitch-Brauer, Simon R. Levinson, Juan Felipe Diaz Quiroz, Eli Eisenberg, Isabel C. Vallecillo-Viejo, Joshua J. C. Rosenthal, Kavita J. Rangan, Maria Fernanda Montiel-Gonzalez, Sonya E. Nemes
Publikováno v:
Nucleic Acids Research
In eukaryotic cells, with the exception of the specialized genomes of mitochondria and plastids, all genetic information is sequestered within the nucleus. This arrangement imposes constraints on how the information can be tailored for different cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a905d5f9b38883ed4dc569cc953d71
https://doi.org/10.1093/nar/gkaa172
https://doi.org/10.1093/nar/gkaa172
Publikováno v:
Journal of Comparative Neurology. 522:4057-4073
Among sodium channel isoforms, Nav1.6 is selectively expressed at nodes of Ranvier in both the CNS and the PNS. However, non-Nav1.6 isoforms such as Nav1.2 are also present at the CNS nodes in early development but gradually diminish later. It has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba34bbd884c2a58837e8dcac542982e2
https://doi.org/10.1002/cne.23656
https://doi.org/10.1002/cne.23656
Publikováno v:
Muscle & Nerve. 46:155-165
Here we review recent research into the mechanisms of chronic pain that has focused on neuronal sodium channels, a target of classic analgesic agents. We first discuss evidence that specific sodium channel isoforms are essential for the detection and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67aebf87d595c6c04c19aa0c2fac4954
https://doi.org/10.1002/mus.23314
https://doi.org/10.1002/mus.23314
Publikováno v:
Neuroscience. 169:1881-1887
Studies show a change in sodium channel (NaCh) expression after inflammatory lesions, and this change is implicated in the generation of pain states. We are using the extracted human tooth to study NaCh expression and here examine the expression of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768165abd24a4e46805f7a6f8846ff03
https://doi.org/10.1016/j.neuroscience.2010.06.044
https://doi.org/10.1016/j.neuroscience.2010.06.044
Autor:
Barbara Carruthers, Sally N. Lawson, Simon R. Levinson, Richard A. Newton, Laiche Djouhri, Carol Berry
Publikováno v:
The Journal of Physiology. 546:565-576
The TTX-sensitive Na(v)1.7 (PN1) Na(+) channel alpha subunit protein is expressed mainly in small dorsal root ganglion (DRG) neurones. This study examines immunocytochemically whether it is expressed exclusively or preferentially in nociceptive prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e19d92d21a91e372014aadea88ac5e
https://doi.org/10.1113/jphysiol.2002.026559
https://doi.org/10.1113/jphysiol.2002.026559
Publikováno v:
Acta pharmacologica Sinica. 36(7)
Methyl eugenol is a major active component extracted from the Chinese herb Asari Radix et Rhizoma, which has been used to treat toothache and other pain. Previous in vivo studies have shown that methyl eugenol has anesthetic and antinociceptive effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44de1a0fcac8c8ca416fdcea69f0cea
https://pubmed.ncbi.nlm.nih.gov/26051112
https://pubmed.ncbi.nlm.nih.gov/26051112
Publikováno v:
The Journal of comparative neurology. 522(18)
Among sodium channel isoforms, Nav 1.6 is selectively expressed at nodes of Ranvier in both the CNS and the PNS. However, non-Nav 1.6 isoforms such as Nav 1.2 are also present at the CNS nodes in early development but gradually diminish later. It has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d7e77748ffa2ea324f9da9139c820dbf
https://pubmed.ncbi.nlm.nih.gov/25048219
https://pubmed.ncbi.nlm.nih.gov/25048219
Autor:
Anthony Wynshaw-Boris, David Ditto, Anne Dell, Howard R. Morris, Nissi Varki, Dzung T. Le, Jeffrey M. Long, Yan Wang, Jamey D. Marth, Jaak Jaeken, Mark Sutton-Smith, Jenny Tan, Harry Schachter, Simon R. Levinson, Maria Panico, Robert M. Campbell
Publikováno v:
Glycobiology. 11:1051-1070
The congenital disorders of glycosylation (CDGs) are recent additions to the repertoire of inherited human genetic diseases. Frequency of CDGs is unknown since most cases are believed to be misdiagnosed or unrecognized. With few patients identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce73e2974d50fda48009f0443cfa581c
https://doi.org/10.1093/glycob/11.12.1051
https://doi.org/10.1093/glycob/11.12.1051
Autor:
Christopher M. Davenport, Anatoly Shcherbatko, Simon R. Levinson, Paul Brehm, Gail Mandel, Joan C. Speh
Publikováno v:
American Journal of Physiology-Cell Physiology. 280:C677-C688
Fully grown oocytes of Xenopus laevis undergo resumption of the meiotic cycle when treated with the steroid hormone progesterone. Previous studies have shown that meiotic maturation results in profound downregulation of specific endogenous membrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c183971cdfe9db68a6d6fad7096f8b
https://doi.org/10.1152/ajpcell.2001.280.3.c677
https://doi.org/10.1152/ajpcell.2001.280.3.c677
Autor:
Peter Shrager, Matthew N. Rasband, Udo Bartsch, Horst Bluethmann, Yolande Lang, Philipp Weber, Simon R. Levinson, Richard U. Margolis, Dirk Montag, R Czaniera, Melitta Schachner
Publikováno v:
The Journal of Neuroscience. 19:4245-4262
Tenascin-R (TN-R), an extracellular matrix glycoprotein of the CNS, localizes to nodes of Ranvier and perineuronal nets and interactsin vitrowith other extracellular matrix components and recognition molecules of the immunoglobulin superfamily. To ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2b4e43fc7baafc76442f9d47e55ecb
https://doi.org/10.1523/jneurosci.19-11-04245.1999
https://doi.org/10.1523/jneurosci.19-11-04245.1999