Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simon R. Hutchings"'
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 88:1035-1041
We examined the effects of hind limb unloading (HLU, 14 days) on constriction of carotid and iliac arterial beds in vivo in thiobutabarbital-anaesthetized rats and isolated carotid and iliac arteries in vitro. Both control and HLU rats had similar ar
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 373:451-456
The venous system plays a crucial role in regulating cardiac output and blood pressure. Although the relationship between obesity and hypertension is well recognized, little is known about the effect of obesity on venous function. We examined if 16-w
Publikováno v:
European Journal of Pharmacology. 508:205-210
We examined if administration of an antioxidant compound protects against the development of insulin resistance and hypertension. Male rats were assigned randomly into four groups, and treated for 12 weeks with normal chow, normal chow plus N-acetylc
Publikováno v:
British Journal of Pharmacology. 143:303-317
The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) currents in the function of the rat aorta was investigated using specific BK(Ca) and K(V) channel inhibitors in single rat aortic myocytes (RAMs) with patch-
Inducible nitric oxide synthase depresses cardiac contractile function in Zucker diabetic fatty rats
Publikováno v:
European journal of pharmacology. 579(1-3)
Cardiac contractile dysfunction is a common occurrence in type 2 diabetes. The aim was to examine if inducible nitric oxide synthase (iNOS) causes cardiac dysfunction in Zucker diabetic fatty (ZDF) rats, a model of type 2 diabetes. ZDF and Zucker lea
Publikováno v:
European journal of pharmacology. 528(1-3)
Excess production of nitric oxide by inducible nitric oxide synthase (iNOS) has been implicated in cardiovascular dysfunction associated with the acute phase of diabetes mellitus. We examined if the selective nitric oxide scavenger, AMD6221 (rutheniu
Publikováno v:
British journal of pharmacology. 143(2)
The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) currents in the function of the rat aorta was investigated using specific BK(Ca) and K(V) channel inhibitors in single rat aortic myocytes (RAMs) with patch-