Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Simon R Myers"'
Publikováno v:
eLife, Vol 12 (2023)
Causal loss-of-function (LOF) variants for Mendelian and severe complex diseases are enriched in 'mutation intolerant' genes. We show how such observations can be interpreted in light of a model of mutation-selection balance and use the model to rela
Externí odkaz:
https://doaj.org/article/7cfc56c5bf724df09e38c99b0144778c
Autor:
Daniel Wells, Emmanuelle Bitoun, Daniela Moralli, Gang Zhang, Anjali Hinch, Julia Jankowska, Peter Donnelly, Catherine Green, Simon R Myers
Publikováno v:
eLife, Vol 9 (2020)
During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3
Externí odkaz:
https://doaj.org/article/d1a82872483147549421c34c8c933946
Autor:
Min Jung, Daniel Wells, Jannette Rusch, Suhaira Ahmad, Jonathan Marchini, Simon R Myers, Donald F Conrad
Publikováno v:
eLife, Vol 8 (2019)
To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals. Here we introduce a model-based factor
Externí odkaz:
https://doaj.org/article/3f8ed4cb8f4f4c0aa569cdb357e27872
Autor:
Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J Ross Chapman, A Radu Aricescu, Simon R Myers
Publikováno v:
eLife, Vol 6 (2017)
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM
Externí odkaz:
https://doaj.org/article/646223caf7b14c82b8a670cb7ca40d0e
Publikováno v:
Archives of Plastic Surgery, Vol 41, Iss 03, Pp 213-217 (2014)
The widespread use of microsurgery in numerous surgical fields has increased the need for basic microsurgical training outside of the operating room. The traditional start of microsurgical training has been in undertaking a 5-day basic microsurgery c
Externí odkaz:
https://doaj.org/article/a6f5d0b380084992a67c7d6fb621dbd7
Autor:
Clement Chi Ming Leung, Ali M Ghanem, Pierluigi Tos, Mihai Ionac, Stefan Froschauer, Simon R Myers
Publikováno v:
Archives of Plastic Surgery, Vol 40, Iss 4, Pp 303-311 (2013)
With an increasing emphasis on microsurgery skill acquisition through simulated training, the need has been identified for standardised training programmes in microsurgery. We have reviewed microsurgery training courses available across the six conti
Externí odkaz:
https://doaj.org/article/32161be3470943b4a14d5972e856f00d
Autor:
Amy L Williams, Giulio Genovese, Thomas Dyer, Nicolas Altemose, Katherine Truax, Goo Jun, Nick Patterson, Simon R Myers, Joanne E Curran, Ravi Duggirala, John Blangero, David Reich, Molly Przeworski, on behalf of the T2D-GENES Consortium
Publikováno v:
eLife, Vol 4 (2015)
Although the past decade has seen tremendous progress in our understanding of fine-scale recombination, little is known about non-crossover (NCO) gene conversion. We report the first genome-wide study of NCO events in humans. Using SNP array data fro
Externí odkaz:
https://doaj.org/article/16ae6f379cf3443e882d52a9a291051f
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004503 (2014)
The pseudoautosomal region (PAR) is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and
Externí odkaz:
https://doaj.org/article/48be570de0ab41d5a3361bee3709eeec
Autor:
Graham Coop, Simon R Myers
Publikováno v:
PLoS Genetics, Vol 3, Iss 3, p e35 (2007)
There is strong evidence that hotspots of meiotic recombination in humans are transient features of the genome. For example, hotspot locations are not shared between human and chimpanzee. Biased gene conversion in favor of alleles that locally disrup
Externí odkaz:
https://doaj.org/article/64a56a11b9de4f85816ec69857fe2fd5
Autor:
Ran Li, Emmanuelle Bitoun, Nicolas Altemose, Robert W. Davies, Benjamin Davies, Simon R. Myers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
During meiotic recombination, genetic information is transferred or exchanged between parental chromosome copies. Using a large hybrid mouse pedigree, the authors generated high-resolution maps of these transfer/exchange events and discovered new pro
Externí odkaz:
https://doaj.org/article/aa2b3f319d0b4ff9a7259cef1a6a8cbc