The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system.

Autor: Gregory James, Simon R Foster, Brian Key, Annemiek Beverdam

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74115 (2013)

The Slit/Robo axon guidance families play a vital role in the formation of neural circuitry within select regions of the developing mouse nervous system. Typically Slits signal through the Robo receptors, however they also have Robo-independent funct

Externí odkaz: https://doaj.org/article/e6a21efe0c714eeca86ceb366534216e

Vascular cells improve functionality of human cardiac organoids

Autor: Holly K. Voges, Simon R. Foster, Liam Reynolds, Benjamin L. Parker, Lynn Devilée, Gregory A. Quaife-Ryan, Patrick R.J. Fortuna, Ellen Mathieson, Rebecca Fitzsimmons, Mary Lor, Christopher Batho, Janice Reid, Mark Pocock, Clayton E. Friedman, Dalia Mizikovsky, Mathias Francois, Nathan J. Palpant, Elise J. Needham, Marina Peralta, Gonzalo del Monte-Nieto, Lynelle K. Jones, Ian M. Smyth, Neda R. Mehdiabadi, Francesca Bolk, Vaibhao Janbandhu, Ernestene Yao, Richard P. Harvey, James J.H. Chong, David A. Elliott, Edouard G. Stanley, Sophie Wiszniak, Quenten Schwarz, David E. James, Richard J. Mills, Enzo R. Porrello, James E. Hudson

Refereed/Peer-reviewed Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction, and utility in disease modeling. Herein w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998951ca54fee675a01326833731eca
https://hdl.handle.net/11541.2/34444

Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139

Autor: Lisa Pallareti, Tine F. Rath, Boris Trapkov, Tsonko Tsonkov, Anders Thorup Nielsen, Kasper Harpsøe, Patrick R. Gentry, Hans Bräuner-Osborne, David E. Gloriam, Simon R. Foster

Publikováno v: Pallareti, L, Rath, T F, Trapkov, B, Tsonkov, T, Nielsen, A T, Harpsøe, K, Gentry, P R, Bräuner-Osborne, H, Gloriam, D E & Foster, S R 2023, ' Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139 ', European Journal of Pharmacology, vol. 943, 175553 . https://doi.org/10.1016/j.ejphar.2023.175553

The orphan G protein-coupled receptor GPR139 is predominantly expressed in the central nervous system and has attracted considerable interest as a therapeutic target. However, the biological role of this receptor remains somewhat elusive, in part due

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df85ff1cb32d698c2e455b397ca2dea3
https://doi.org/10.1016/j.ejphar.2023.175553

Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2

Autor: Martin J. Stone, Anup Shah, Oded Kleifeld, Ralf B. Schittenhelm, Meritxell Canals, Cheng Huang, Simon R. Foster

Publikováno v: J Biol Chem

Leukocyte recruitment is a universal feature of tissue inflammation and regulated by the interactions of chemokines with their G protein–coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505094ce6d8180f3c2d2c90451084238
https://doi.org/10.1074/jbc.ra119.012026

Discovery of Potent Cyclic Sulfopeptide Chemokine Inhibitors via Reprogrammed Genetic Code mRNA Display

Autor: Daniel J Ford, Martin J. Stone, Minglong Liu, Ram Prasad Bhusal, Seino A. K. Jongkees, Richard J. Payne, Jason Johansen-Leete, Simon R. Foster, Hiroaki Suga, Toby Passioura

Publikováno v: Journal of the American Chemical Society. 142:9141-9146

Targeting chemokine signaling is an attractive avenue for the treatment of inflammatory disorders. Tyrosine sulfation is an important post-translational modification (PTM) that enhances chemokine-receptor binding and is also utilized by a number of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2acd49507c63ab60282b1e7f4aa829
https://doi.org/10.1021/jacs.0c03152