A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer's Disease.

Autor: Natalie Ness, Simon R Schultz

Publikováno v: PLoS Computational Biology, Vol 17, Iss 6, p e1009115 (2021)

Alzheimer's Disease (AD) is characterized by progressive neurodegeneration and cognitive impairment. Synaptic dysfunction is an established early symptom, which correlates strongly with cognitive decline, and is hypothesised to mediate the diverse ne

Externí odkaz: https://doaj.org/article/56a081e14033483d9fa2b0f0f17657fe

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

Autor: Polona Jager, Gerald Moore, Padraic Calpin, Xhuljana Durmishi, Irene Salgarella, Lucy Menage, Yoshiaki Kita, Yan Wang, Dong Won Kim, Seth Blackshaw, Simon R Schultz, Stephen Brickley, Tomomi Shimogori, Alessio Delogu

Publikováno v: eLife, Vol 10 (2021)

The ubiquitous presence of inhibitory interneurons in the thalamus of primates contrasts with the sparsity of interneurons reported in mice. Here, we identify a larger than expected complexity and distribution of interneurons across the mouse thalamu

Externí odkaz: https://doaj.org/article/5eabf25104604dd29e3e94cb4f9e7ca9

Single-Neuron Level One-Photon Voltage Imaging With Sparsely Targeted Genetically Encoded Voltage Indicators

Autor: Peter Quicke, Chenchen Song, Eric J. McKimm, Milena M. Milosevic, Carmel L. Howe, Mark Neil, Simon R. Schultz, Srdjan D. Antic, Amanda J. Foust, Thomas Knöpfel

Publikováno v: Frontiers in Cellular Neuroscience, Vol 13 (2019)

Voltage imaging of many neurons simultaneously at single-cell resolution is hampered by the difficulty of detecting small voltage signals from overlapping neuronal processes in neural tissue. Recent advances in genetically encoded voltage indicator (

Externí odkaz: https://doaj.org/article/6a0044e1d29140aab159ccbfbb0217e9

Neuronal gain modulability is determined by dendritic morphology: A computational optogenetic study.

Autor: Sarah Jarvis, Konstantin Nikolic, Simon R Schultz

Publikováno v: PLoS Computational Biology, Vol 14, Iss 3, p e1006027 (2018)

The mechanisms by which the gain of the neuronal input-output function may be modulated have been the subject of much investigation. However, little is known of the role of dendrites in neuronal gain control. New optogenetic experimental paradigms ba

Externí odkaz: https://doaj.org/article/c7e2a12c293143d0b36584c5d13a809c

Neuronal signature of spatial decision-making during navigation by freely moving rats using calcium imaging

Autor: Francesco Gobbo, Rufus Mitchell-Heggs, Dorothy Tse, Meera Al Omrani, Patrick A. Spooner, Simon R. Schultz, Richard G. M. Morris

Publikováno v: Gobbo, F, Mitchell-Heggs, R, Tse, D, Al-Omrani, M, Spooner, P, Shultz, S R & Morris, R 2022, ' Neuronal signature of spatial decision-making during navigation by freely moving rats using calcium imaging ', Proceedings of the National Academy of Sciences, vol. 119, no. 44, e2212152119 . https://doi.org/10.1073/pnas.2212152119

A challenge in spatial memory is understanding how place cell firing contributes to decision-making in navigation. A spatial recency task was created in which freely moving rats first became familiar with a spatial context over several days and there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052e00b5b046643e6d51edd1357205ed
https://hdl.handle.net/20.500.11820/4ba36d4b-ac33-4435-a62e-a45db0334b40