Entropic bonding of the type 1 pilus from experiment and simulation

Autor: Fabiano Corsetti, Alvaro Alonso-Caballero, Simon Poly, Raul Perez-Jimenez, Emilio Artacho

Publikováno v: Royal Society Open Science, Vol 7, Iss 4 (2020)

The type 1 pilus is a bacterial filament consisting of a long coiled proteic chain of subunits joined together by non-covalent bonding between complementing β-strands. Its strength and structural stability are critical for its anchoring function in

Externí odkaz: https://doaj.org/article/5a2c1149b48d4ba18f0539c55ff9c3e2

Hyperspectral infrared nanoimaging of organic samples based on Fourier transform infrared nanospectroscopy

Autor: Iban Amenabar, Simon Poly, Monika Goikoetxea, Wiwat Nuansing, Peter Lasch, Rainer Hillenbrand

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

In hyperspectral imaging a broadband spectrum is recorded at each pixel, which creates information-rich images. Here, the authors combine this concept with Fourier transform infrared nanospectroscopy to achieve 5,000-pixel, nanoscale-resolution image

Externí odkaz: https://doaj.org/article/518d239fcb1e428dae8d88adc9daf652

Mechanical architecture and folding of E. coli type 1 pilus domains

Autor: Simon Poly, Emilio Artacho, Jörg Schönfelder, Raul Perez-Jimenez, Fabiano Corsetti, David De Sancho, Alvaro Alonso-Caballero

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications

Uropathogenic Escherichia coli attach to tissues using pili type 1. Each pilus is composed by thousands of coiled FimA domains followed by the domains of the tip fibrillum, FimF-FimG-FimH. The domains are linked by non-covalent β-strands that must r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2318b774d85c897415c0e158142c155b
http://link.springer.com/article/10.1038/s41467-018-05107-6

Implications of protein structure instability: From physiological to pathological secondary structure

Autor: Igor B. Bronstein, Simon Poly, Alyona Sukhanova, Anton A. Shemetov, Igor Nabiev

Publikováno v: Biopolymers
Biopolymers, Wiley, 2012, 97 (8), pp.577-588. ⟨10.1002/bip.22055⟩

Proteins are folded during their synthesis; this process may be spontaneous or assisted. Both phenomena are carefully regulated by the “housekeeping” mechanism and molecular chaperones to avoid the appearance of misfolded proteins. Unfolding proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097c71fff84251b7c09c78bd49445228

Quantum dots induce charge-specific amyloid-like fibrillation of insulin at physiological conditions

Autor: Anton A. Shemetov, Simon Poly, Alyona Sukhanova, Igor Nabiev

Publikováno v: Proceedings of SPIE, the International Society for Optical Engineering
Proceedings of SPIE, the International Society for Optical Engineering, SPIE, The International Society for Optical Engineering, 2012, Nanosystems in Engineering and Medicine, 8548, pp.85485F. ⟨10.1117/12.946606⟩
Nanosystems in Engineering and Medicine

International audience; Agglomeration of some proteins may give rise to aggregates that have been identified as the main cause of amyloid diseases. For example, fibrillation of insulin is related to diabetes mellitus. Quantum dots (QDs) are of specia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aea1c349af8eaebe9274b44eb8e7612
https://doi.org/10.1117/12.946606