Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Simon Plummer"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
In vivo treatment of rats with phenobarbital (PB) induces liver enzyme induction associated with hepatocyte hypertrophy. In the present study we used a novel microTMA technology coupled with artificial intelligence (AI) driven image analysis and prot
Externí odkaz:
https://doaj.org/article/e8d8f42f4cd447d2ac25a39e8d006d94
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Simon Plummer, Bobby Beaumont, Matthew Elcombe, Stephanie Wallace, Jayne Wright, Elizabeth F Mcinnes, Richard A Currie, David Cowie
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 155-161 (2021)
Species differences in hepatic metabolism of thyroxine (T4) by uridine diphosphate glucuronosyl transferase (UGT) and susceptibility to thyroid hormone imbalance could underlie differences in thyroid carcinogenesis caused by hepatic enzyme inducers i
Externí odkaz:
https://doaj.org/article/df6e7a9cd963474aa45fe0574be13157
Autor:
Simon Plummer, Bobby Beaumont, Stephanie Wallace, Graeme Ball, Jayne Wright, Liz McInnes, Richard Currie, Rich Peffer, David Cowie
Publikováno v:
Toxicology Reports, Vol 6, Iss , Pp 998-1005 (2019)
Characterisation of the mode of action (MOA) of constitutive androstane receptor (CAR)-mediated rodent liver tumours involves measurement 5 key events including activation of the CAR receptor, altered gene expression, hepatocellular proliferation, cl
Externí odkaz:
https://doaj.org/article/34784676fbeb4bbebd439dbf29108d12
Autor:
Michael Römer, Johannes Eichner, Ute Metzger, Markus F Templin, Simon Plummer, Heidrun Ellinger-Ziegelbauer, Andreas Zell
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97640 (2014)
In the area of omics profiling in toxicology, i.e. toxicogenomics, characteristic molecular profiles have previously been incorporated into prediction models for early assessment of a carcinogenic potential and mechanism-based classification of compo
Externí odkaz:
https://doaj.org/article/fbc0923c72014ff8b57a46859d6857ea
Autor:
François Chauvigné, Simon Plummer, Laurianne Lesné, Jean-Pierre Cravedi, Nathalie Dejucq-Rainsford, Alexis Fostier, Bernard Jégou
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27172 (2011)
Exposure to phthalates in utero alters fetal rat testis gene expression and testosterone production, but much remains to be done to understand the mechanisms underlying the direct action of phthalate within the fetal testis. We aimed to investigate t
Externí odkaz:
https://doaj.org/article/eea6dfa2745f42329468c6f20b6b2a9d
Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues
Autor:
Elizabeth F. McInnes, Stephanie Wallace, David Cowie, Simon Plummer, Matthew Elcombe, Richard A. Currie, Bobby Beaumont, Jayne Wright
Publikováno v:
Toxicology Reports, Vol 8, Iss, Pp 155-161 (2021)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Highlights • Species differences in UGT induction could mediate thyroid cancer susceptibility. • The effect of CAR activators on rat thyroid carcinogenesis could be partly explained by differential induction of Ugt 2b17.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14832b7cdf9942079952c6c70ad2ff80
https://doi.org/10.1016/j.toxrep.2020.12.019
https://doi.org/10.1016/j.toxrep.2020.12.019
Autor:
Liz McInnes, Bobby Beaumont, Graeme Ball, Simon Plummer, David Cowie, Rich Peffer, Stephanie Wallace, Jayne Wright, Richard A. Currie
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 6, Iss, Pp 998-1005 (2019)
Toxicology Reports, Vol 6, Iss, Pp 998-1005 (2019)
Highlights • The first demonstration of phenobarbital-induced hepatocyte proliferation in 3D liver microtissue models. • Integration of quantitative histopathology data with genomics (transcriptomics/proteomics). • In vitro cross-species risk a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9162883e86b9f1e4829015243f202ca
https://doi.org/10.1016/j.toxrep.2019.09.010
https://doi.org/10.1016/j.toxrep.2019.09.010
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 5, Iss, Pp 309-313 (2018)
Toxicology Reports, Vol 5, Iss, Pp 309-313 (2018)
An increased incidence of liver tumours in the long term rodent bioassay is not an uncommon finding, invariably as a result of a non-genotoxic mode of action. Non-genotoxic liver carcinogenesis has been found to involve activation of certain nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed1c47dd7bcf3b3e0c72a8c8ae2c3a2
http://europepmc.org/articles/PMC5856664
http://europepmc.org/articles/PMC5856664
Autor:
Alfredo Quinones-Hinojosa, Simon Plummer, Thomas Hartung, Roslyn Lloyd, Paula Schiapparelli, David Pamies, Stephanie Wallace, Graeme Ball
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific reports, vol. 9, no. 1, pp. 1407
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific reports, vol. 9, no. 1, pp. 1407
A high throughput histology (microTMA) platform was applied for testing drugs against tumors in a novel 3D heterotypic glioblastoma brain sphere (gBS) model consisting of glioblastoma tumor cells, iPSC-derived neurons, glial cells and astrocytes grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6dc248e30894a8dad04f75bea2f4ea
http://europepmc.org/articles/PMC6363784
http://europepmc.org/articles/PMC6363784
Autor:
Anja Rode, Clifford R. Elcombe, Simon Plummer, Nico Scheer, C. Roland Wolf, Ortwin Vogel, Jillian Ross, Conrad C. Bower, Colin J. Henderson
Publikováno v:
Toxicological Sciences. 116:452-466
Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab214a64c0ee77068479080c40b5173
https://doi.org/10.1093/toxsci/kfq118
https://doi.org/10.1093/toxsci/kfq118