Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Simon Peter Tickle"'
Autor:
Bernie Sweeney, Dimitris Josephides, Maeva Vallet, Zachary Owen, Clive A. Smith, Simon Peter Tickle, Raphael Ruis, Liu Xin, Xin Li, William F. Young, Darren Matthews, William Whitley, Elena Shvets, Giuseppe Benazzi, Benedict Mackworth, Matthew Hinchliffe, Rehak Marian, Daniel John Lightwood, Craig Frank F, Robert Salter, Drew Geere, David R. Holmes, Davoli Serena A, Frank Gesellchen, Sinan Gokkaya, James White, Dale Starkie
Publikováno v:
SLAS technology. 25(2)
The primary goal of bioprocess cell line development is to obtain high product yields from robustly growing and well-defined clonal cell lines in timelines measured in weeks rather than months. Likewise, high-throughput screening of B cells and hybri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcee3d53e993afd79ebb08ed624ea42e
https://pubmed.ncbi.nlm.nih.gov/31941402
https://pubmed.ncbi.nlm.nih.gov/31941402
Autor:
Louise Howells, Victoria O’Dowd, Daniel John Lightwood, Kevin Whale, Dale Starkie, Simon Peter Tickle, Mark Saunders, David K.H. Lee
Publikováno v:
Journal of biomolecular screening. 20(4)
For a therapeutic antibody to succeed, it must meet a range of potency, stability, and specificity criteria. Many of these characteristics are conferred by the amino acid sequence of the heavy and light chain variable regions and, for this reason, ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bb5c89eb32dfaa3000bd0682136df7
https://pubmed.ncbi.nlm.nih.gov/25548140
https://pubmed.ncbi.nlm.nih.gov/25548140
Autor:
John Robert Porter, Neville Willmott, Andrew Mountain, Tetsuro Kubota, Xiaoen Wang, Robert M. Hoffman, Andrew T. Millican, Zili An, A. R. Moossa, Andrew J. P. Docherty, Surinder K. Chander, Richard Morphy, R. Ola Epemolu, Simon Peter Tickle
Publikováno v:
Clinical and Experimental Metastasis. 15:184-195
In this study, we describe the activity of CT1746, an orally-active synthetic MMP inhibitor that has a greater specificity for gelatinase A, gelatinase B and stromelysin than for interstitial collagenase and matrilysin, in a nude mouse model that bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71608d7b9c12bcd864f7edacf0ed1573
https://doi.org/10.1023/a:1018461112732
https://doi.org/10.1023/a:1018461112732
Autor:
Karen Zinkewich-Peotti, John F. DiJoseph, Erwin R. Boghaert, Simon Peter Tickle, Nitin K. Damle, Douglas Armellino, Kiran Khandke, Neil Weir, Hamann Philip Ross, Sue Stephens, Andrew George Popplewell, Heather Margaret Ladyman, Alastair David Griffiths Lawson, Arthur Kunz
Publikováno v:
Cancer immunology, immunotherapy : CII. 54(1)
Antibody-targeted chemotherapy with immunoconjugates of calicheamicin is a clinically validated strategy in cancer therapy. This study describes the selection of a murine anti-CD22 mAb, m5/44, as a targeting agent, its conjugation to a derivative of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5daede248e00657815394d7eabc6fb
https://pubmed.ncbi.nlm.nih.gov/15693135
https://pubmed.ncbi.nlm.nih.gov/15693135
Autor:
Simon Peter Tickle, Andrew J. P. Docherty, Ute M. Moll, Hosein M. Zarrabi, William G. Stetler-Stevenson, Terry S. Baker, Stanley Zucker, Rita Marie Lysik
Publikováno v:
Annals of the New York Academy of Sciences. 732
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1f7961116d4a6b93ba1cab0976df95
https://pubmed.ncbi.nlm.nih.gov/7978797
https://pubmed.ncbi.nlm.nih.gov/7978797
Autor:
Mark I. Cockett, Simon Peter Tickle, James O'Connell, Andrew J. P. Docherty, Janeen M. Scothern, Frances Willenbrock, Gillian Murphy, Stanley Zucker, Thomas Crabbe
Publikováno v:
Biochemistry. 33(21)
Human gelatinase A, a member of the matrix metalloproteinase family, is secreted from cells as the M(r) 72,000 latent precursor, progelatinase A. The autolytic removal of an N-terminal propeptide generates the M(r) 66,000 active form. Mutants of reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fec372546eb4f344b2438cd82601d1
https://pubmed.ncbi.nlm.nih.gov/7911325
https://pubmed.ncbi.nlm.nih.gov/7911325
Autor:
Simon Peter Tickle, Andrew J. P. Docherty, Gillian Murphy, Jayne B. Hipkiss, Alastair David Griffiths Lawson, Susan Cooksley, Eileen Holmes-Ievers
Publikováno v:
Matrix (Stuttgart, Germany). 10(5)
Immunoassays have been developed for human collagenase, stromelysin, tissue inhibitor of metalloproteinases (TIMP) and TIMP complexed with both of the active enzymes. Selection of antibodies of defined specificity enabled measurement of both the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da9cd671976bf518c1d7dd85e19d700
https://pubmed.ncbi.nlm.nih.gov/1964712
https://pubmed.ncbi.nlm.nih.gov/1964712