Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Simon P. Pearce"'
Autor:
Robert E. Hynds, Ariana Huebner, David R. Pearce, Mark S. Hill, Ayse U. Akarca, David A. Moore, Sophia Ward, Kate H. C. Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A. Wilson, Oriol Pich, Carlos Martínez-Ruiz, A. S. Md Mukarram Hossain, Simon P. Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak Chandrasekharan, Krishna K. Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E. Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J. Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A. J. Crosbie, Caroline Dive, Sergio A. Quezada, Sam M. Janes, Mariam Jamal-Hanjani, Teresa Marafioti, TRACERx consortium, Nicholas McGranahan, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled in the TRACERx study. Multi-regio
Externí odkaz:
https://doaj.org/article/15a9cb6171ca46d4a07fbfbe6bf74b76
Autor:
Alicia-Marie Conway, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Francesca Chemi, Dan Slane-Tan, Saba Ferdous, A. S. Md Mukarram Hossain, Katarzyna Kamieniecka, Daniel J. White, Claire Mitchell, Alastair Kerr, Matthew G. Krebs, Gerard Brady, Caroline Dive, Natalie Cook, Dominic G. Rothwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Cancers of Unknown Primary (CUP) remains a diagnostic and therapeutic challenge due to biological heterogeneity and poor responses to standard chemotherapy. Predicting tissue-of-origin (TOO) molecularly could help refine this diagnosis, with
Externí odkaz:
https://doaj.org/article/d4bcd616a1c54d2c97e8ef0bccad3ec9
Autor:
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (C
Externí odkaz:
https://doaj.org/article/a99beedee95f4504bd782063edbc7711
Autor:
Michael Cole, James Wason, Jenn Walker, Naomi McGregor, Rebecca H Maier, Simon H Pearce, Penny Bradley, Faye Wolstenhulme, Irena Bibby, Lydia Grixti
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Severe Graves’ disease is a life-changing condition with poor outcomes from currently available treatments. It is caused by directly pathogenic thyroid-stimulating hormone receptor-stimulating antibodies (TRAb), which are secreted from
Externí odkaz:
https://doaj.org/article/f7324f0310e148c3acfe10c7bc2b9885
Autor:
Robert D. Morgan, Andrew R. Clamp, Daniel J. White, Marcus Price, George J. Burghel, W. David J. Ryder, Reem D. Mahmood, Alexander D. Murphy, Jurjees Hasan, Claire L. Mitchell, Zena Salih, Chelsey Wheeler, Emma Buckley, Joanna Truelove, Georgia King, Yasmina Ainaoui, Sanjeev S. Bhaskar, Joseph Shaw, D. Gareth R. Evans, Bedirhan Kilerci, Simon P. Pearce, Gerard Brady, Caroline Dive, James P.B. O'Connor, Andrew J. Wallace, Dominic G. Rothwell, Richard J. Edmondson, Gordon C. Jayson
Publikováno v:
Clinical Cancer Research. :OF1-OF10
Purpose: A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.
Autor:
Francesca Chemi, Simon P. Pearce, Alexandra Clipson, Steven M. Hill, Alicia-Marie Conway, Sophie A. Richardson, Katarzyna Kamieniecka, Rebecca Caeser, Daniel J. White, Sumitra Mohan, Victoria Foy, Kathryn L. Simpson, Melanie Galvin, Kristopher K. Frese, Lynsey Priest, Jacklynn Egger, Alastair Kerr, Pierre P. Massion, John T. Poirier, Gerard Brady, Fiona Blackhall, Dominic G. Rothwell, Charles M. Rudin, Caroline Dive
Publikováno v:
Nature Cancer. 3:1260-1270
Small cell lung cancer (SCLC) is characterized by morphologic, epigenetic and transcriptomic heterogeneity. Subtypes based upon predominant transcription factor expression have been defined that, in mouse models and cell lines, exhibit potential diff
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
BRCA2 reversion mutation detected in cell-free circulating DNA from patient 16.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8190683682e17f23bf7a91a183e796
https://doi.org/10.1158/1078-0432.22490383.v1
https://doi.org/10.1158/1078-0432.22490383.v1
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Purpose:A single maintenance course of a PARP inhibitor (PARPi) improves progression-free survival (PFS) in germline BRCA1/2-mutant high-grade serous ovarian cancer (gBRCAm-HGSOC). The feasibility of a second maintenance course of PARPi was unknown.P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::383a4bd467a2e8ab9634c5efb3f01674
https://doi.org/10.1158/1078-0432.c.6533146
https://doi.org/10.1158/1078-0432.c.6533146
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Supplementary Methodology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac4b273d975d5742c671ed36cc435ae
https://doi.org/10.1158/1078-0432.22490380
https://doi.org/10.1158/1078-0432.22490380
Autor:
Gordon C. Jayson, Richard J. Edmondson, Dominic G. Rothwell, Andrew J. Wallace, James P.B. O'Connor, Caroline Dive, Gerard Brady, Simon P. Pearce, Bedirhan Kilerci, D. Gareth R. Evans, Joseph Shaw, Sanjeev S. Bhaskar, Yasmina Ainaoui, Georgia King, Joanna Truelove, Emma Buckley, Chelsey Wheeler, Zena Salih, Claire L. Mitchell, Jurjees Hasan, Alexander D. Murphy, Reem D. Mahmood, W. David J. Ryder, George J. Burghel, Marcus Price, Daniel J. White, Andrew R. Clamp, Robert D. Morgan
Liquid biopsy time points.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6c35925d33a5ace1475cad8e3ca56f
https://doi.org/10.1158/1078-0432.22490371
https://doi.org/10.1158/1078-0432.22490371