Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Simon P. Langdon"'
Autor:
Sarah J. Taylor, Robert L. Hollis, Charlie Gourley, C. Simon Herrington, Simon P. Langdon, Mark J. Arends
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDNA damage repair is frequently dysregulated in high grade serous ovarian cancer (HGSOC), which can lead to changes in chemosensitivity and other phenotypic differences in tumours. RFWD3, a key component of multiple DNA repair and maintenan
Externí odkaz:
https://doaj.org/article/0f37cae0814847a1b8d645d8c736be1e
Autor:
Kate M. Moore, Vera Cerqueira, Kenneth G. MacLeod, Peter Mullen, Richard L. Hayward, Simon Green, David J. Harrison, David A. Cameron, Simon P. Langdon
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1, Pp 97-116 (2022)
Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation. Methods: The MCF7 breast cancer model is sensitive to estrogens and anti-estrog
Externí odkaz:
https://doaj.org/article/1befcc865c8d466aa9837be2e933674b
Autor:
Mark Gray, Arran K. Turnbull, Carol Ward, James Meehan, Carlos Martínez-Pérez, Maria Bonello, Lisa Y. Pang, Simon P. Langdon, Ian H. Kunkler, Alan Murray, David Argyle
Publikováno v:
Radiation Oncology, Vol 14, Iss 1, Pp 1-19 (2019)
Abstract Background Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation by cells that have dev
Externí odkaz:
https://doaj.org/article/f86ee81a892849e88ed5db0ce297194d
Autor:
Edward J. Jarman, Carol Ward, Arran K. Turnbull, Carlos Martinez-Perez, James Meehan, Chrysi Xintaropoulou, Andrew H. Sims, Simon P. Langdon
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-18 (2019)
Abstract Background Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whos
Externí odkaz:
https://doaj.org/article/923a851c858a45a7b0788fc90b57314e
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 2 (2021)
Aim: Nuclear factor erythroid 2-related factor 2 (NRF2) is a key component in the cell’s response to oxidative and electrophilic stress and is a transcription factor regulating the expression of a collection of anti-oxidative and cytoprotective gen
Externí odkaz:
https://doaj.org/article/2b3b888a450a4c6abc381c6ffe28e8fd
Autor:
James Meehan, Mark Gray, Carlos Martínez-Pérez, Charlene Kay, Lisa Y. Pang, Jennifer A. Fraser, Amy V. Poole, Ian H. Kunkler, Simon P. Langdon, David Argyle, Arran K. Turnbull
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Radiotherapy remains an important treatment modality in nearly two thirds of all cancers, including the primary curative or palliative treatment of breast cancer. Unfortunately, largely due to tumor heterogeneity, tumor radiotherapy response rates ca
Externí odkaz:
https://doaj.org/article/f1ccff91ed624c99bba0f0182c1ae428
Autor:
Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O. Michie, Alistair R. W. Williams, Tzyvia Rye, Charlie Gourley, Simon P. Langdon
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular components (GLUT1, HKI
Externí odkaz:
https://doaj.org/article/1b6941182481481888f6c50266b13ad2
Autor:
Simon P. Langdon
Publikováno v:
Cancers, Vol 12, Iss 10, p 2744 (2020)
Estrogen receptor signaling plays
Externí odkaz:
https://doaj.org/article/fa4e7ba9058849679430a6a17061b8c4
Publikováno v:
Cancers, Vol 12, Iss 6, p 1647 (2020)
The estrogen receptor (ER) has functionality in selected ovarian cancer subtypes and represents a potential target for therapy. The majority (>80%) of high grade serous, low grade serous and endometrioid carcinomas and many granulosa cell tumors expr
Externí odkaz:
https://doaj.org/article/8bf703427cd940ebbfc6ba000c66e920
Autor:
Alexey Goltsov, Yusuf Deeni, Hilal S. Khalil, Tero Soininen, Stylianos Kyriakidis, Huizhong Hu, Simon P. Langdon, David J. Harrison, James Bown
Publikováno v:
Cells, Vol 3, Iss 2, Pp 563-591 (2014)
The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to sin
Externí odkaz:
https://doaj.org/article/6972b56a5276465a9c6d42ba5abc98ed