Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Simon P. Johnson"'
Autor:
Dimie Ogoina, Mahmmod Muazu Dalhat, Ballah Akawu Denue, Mildred Okowa, Nneka Marian Chika-Igwenyi, Sebastine Oseghae Oiwoh, Ekaete Alice Tobin, Hakeem Abiola Yusuff, Anastacia Okwudili Ojimba, Umenzekwe Chukwudi Christian, John-Tunde Aremu, Simji Samuel Gomerep, Kambai Lalus Habila, Sati Klein Awang, Olukemi Adekanmbi, Michael Iroezindu, Asukwo Onukak, Olanrewaju Falodun, Mogaji Sunday, Simon Mafuka Johnson, Abimbola Olaitan, Chizaram Onyeaghala, Datonye Alasia, Juliet Mmerem, Uche Unigwe, Vivian Kwaghe, Mukhtar Abdulmajid Adeiza
Publikováno v:
Emerging Infectious Diseases, Vol 30, Iss 9, Pp 1799-1808 (2024)
To investigate epidemiology of and risk factors for laboratory-confirmed mpox during the 2022 outbreak in Nigeria, we enrolled 265 persons with suspected mpox. A total of 163 (61.5%) were confirmed to have mpox; 137 (84.0%) were adults, 112 (68.7%) m
Externí odkaz:
https://doaj.org/article/0c05a64c2b48473fa691ccf1dd93eac1
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-8 (2024)
Abstract Background Lymphangioleiomyomatosis (LAM) is common in tuberous sclerosis complex (TSC) yet under recognised with management mostly based upon evidence obtained from patients with sporadic LAM. We performed a prospective audit of patients wi
Externí odkaz:
https://doaj.org/article/81ebfc6a88b641acb1299c3726a5b50b
Autor:
Sophia Zilber, Kasey Woleben, Simon C. Johnson, Carolina Fischinger Moura de Souza, Danielle Boyce, Kevin Freiert, Courtney Boggs, Souad Messahel, Melinda J. Burnworth, Titilola M. Afolabi, Saima Kayani
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-17 (2023)
Abstract Background Leigh Syndrome (LS) is a rare genetic neurometabolic disorder, that leads to the degeneration of the central nervous system and subsequently, early death. LS can be caused by over 80 mutations in mitochondrial or nuclear DNA. Pati
Externí odkaz:
https://doaj.org/article/fe68946950d14bbb98164e5360e9fb52
Autor:
Michael A. Portelli, Sangita Bhaker, Vincent Pang, David O. Bates, Simon R. Johnson, Andrew P. Mazar, Dominick Shaw, Christopher Brightling, Ian Sayers
Publikováno v:
Clinical and Translational Allergy, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Background Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. Object
Externí odkaz:
https://doaj.org/article/b98b2138b6a345bba5e4c156f9115f19
Autor:
Allison Hanaford, Simon C. Johnson
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-12 (2022)
Abstract Background Genetic mitochondrial diseases represent a significant challenge to human health. These diseases are extraordinarily heterogeneous in clinical presentation and genetic origin, and often involve multi-system disease with severe pro
Externí odkaz:
https://doaj.org/article/5548eef25fa543c1a226f5a3db5e5730
Publikováno v:
Antimicrobial Stewardship & Healthcare Epidemiology, Vol 3 (2023)
Abstract Background: As nurse practitioners and physician assistants (APPs) become more prevalent in delivering pediatric care, their involvement in antimicrobial stewardship efforts increases in importance. This project aimed to create and assess t
Externí odkaz:
https://doaj.org/article/8047aa13708c4caaa158d80a5c224f46
Autor:
Maurizio Chioccioli, Subhadeep Roy, Rachel Newell, Linda Pestano, Brent Dickinson, Kevin Rigby, Jose Herazo-Maya, Gisli Jenkins, Steward Ian, Gauri Saini, Simon R. Johnson, Rebecca Braybrooke, Guying Yu, Maor Sauler, Farida Ahangari, Shuizi Ding, Joseph DeIuliis, Nachelle Aurelien, Rusty L. Montgomery, Naftali Kaminski
Publikováno v:
EBioMedicine, Vol 85, Iss , Pp 104304- (2022)
Summary: Background: MicroRNAs are non-coding RNAs that negatively regulate gene networks. Previously, we reported that systemically delivered miR-29 mimic MRG-201 reduced fibrosis in animal models, supporting the consideration of miR-29-based therap
Externí odkaz:
https://doaj.org/article/0b9f4e10e633477c90233cf6675cf157
Autor:
Dorian M. Cheff, Alysson R. Muotri, Brent R. Stockwell, Edward E. Schmidt, Qitao Ran, Reena V. Kartha, Simon C. Johnson, Plavi Mittal, Elias S. J. Arnér, Kristen M. Wigby, Matthew D. Hall, Sanath Kumar Ramesh
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-15 (2021)
Abstract Background Extremely rare progressive diseases like Sedaghatian-type Spondylometaphyseal Dysplasia (SSMD) can be neonatally lethal and therefore go undiagnosed or are difficult to treat. Recent sequencing efforts have linked this disease to
Externí odkaz:
https://doaj.org/article/b03c183bb33b4ee8b5828e0234f4c132
Autor:
Julia C. Stokes, Rebecca L. Bornstein, Katerina James, Kyung Yeon Park, Kira A. Spencer, Katie Vo, John C. Snell, Brittany M. Johnson, Philip G. Morgan, Margaret M. Sedensky, Nathan A. Baertsch, Simon C. Johnson
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Symmetric, progressive, necrotizing lesions in the brainstem are a defining feature of Leigh syndrome (LS). A mechanistic understanding of the pathogenesis of these lesions has been elusive. Here, we report that leukocyte proliferation is causally in
Externí odkaz:
https://doaj.org/article/aee55270c21c4af99e428af868af6b62
Autor:
Rebecca Bornstein, Katerina James, Julia Stokes, Kyung Yeon Park, Ernst-Bernhard Kayser, John Snell, Angela Bard, Yihan Chen, Franck Kalume, Simon C. Johnson
Publikováno v:
Neurobiology of Disease, Vol 163, Iss , Pp 105594- (2022)
Genetic mitochondrial diseases are the most frequent cause of inherited metabolic disorders and one of the most prevalent causes of heritable neurological disease. Leigh syndrome is the most common clinical presentation of pediatric mitochondrial dis
Externí odkaz:
https://doaj.org/article/24a74f13f1394ae6aa92f6a8f0869eee