Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs

Autor: Simon R. Green, Susan H. Davis, Sebastian Damerow, Curtis A. Engelhart, Michael Mathieson, Beatriz Baragaña, David A. Robinson, Jevgenia Tamjar, Alice Dawson, Fabio K. Tamaki, Kirsteen I. Buchanan, John Post, Karen Dowers, Sharon M. Shepherd, Chimed Jansen, Fabio Zuccotto, Ian H. Gilbert, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Maria Osuna-Cabello, Esther Pérez-Herrán, María José Rebollo, Laura Guijarro López, Patricia Casado Castro, Isabel Camino, Heather C. Kim, James M. Bean, Navid Nahiyaan, Kyu Y. Rhee, Qinglan Wang, Vee Y. Tan, Helena I. M. Boshoff, Paul J. Converse, Si-Yang Li, Yong S. Chang, Nader Fotouhi, Anna M. Upton, Eric L. Nuermberger, Dirk Schnappinger, Kevin D. Read, Lourdes Encinas, Robert H. Bates, Paul G. Wyatt, Laura A. T. Cleghorn

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Tuberculosis is a major cause of mortality, and the rise of drug-resistant strains of Mycobacterium tuberculosis requires the urgent development of safe and effective treatments. In this work, the authors develop a compound against lysyl-tRNA synthet

Externí odkaz: https://doaj.org/article/3aefb9dc25794e5b8cda7dfd998654ed

Achievement of the Planetary Defense Investigations of the Double Asteroid Redirection Test (DART) Mission

Autor: Nancy L. Chabot, Andrew S. Rivkin, Andrew F. Cheng, Olivier S. Barnouin, Eugene G. Fahnestock, Derek C. Richardson, Angela M. Stickle, Cristina A. Thomas, Carolyn M. Ernst, R. Terik Daly, Elisabetta Dotto, Angelo Zinzi, Steven R. Chesley, Nicholas A. Moskovitz, Brent W. Barbee, Paul Abell, Harrison F. Agrusa, Michele T. Bannister, Joel Beccarelli, Dmitriy L. Bekker, Megan Bruck Syal, Bonnie J. Buratti, Michael W. Busch, Adriano Campo Bagatin, Joseph P. Chatelain, Sidney Chocron, Gareth S. Collins, Luca Conversi, Thomas M. Davison, Mallory E. DeCoster, J. D. Prasanna Deshapriya, Siegfried Eggl, Raymond C. Espiritu, Tony L. Farnham, Marin Ferrais, Fabio Ferrari, Dora Föhring, Oscar Fuentes-Muñoz, Igor Gai, Carmine Giordano, David A. Glenar, Edward Gomez, Dawn M. Graninger, Simon F. Green, Sarah Greenstreet, Pedro H. Hasselmann, Isabel Herreros, Masatoshi Hirabayashi, Marek Husárik, Simone Ieva, Stavro L. Ivanovski, Samuel L. Jackson, Emmanuel Jehin, Martin Jutzi, Ozgur Karatekin, Matthew M. Knight, Ludmilla Kolokolova, Kathryn M. Kumamoto, Michael Küppers, Fiorangela La Forgia, Monica Lazzarin, Jian-Yang Li, Tim A. Lister, Ramin Lolachi, Michael P. Lucas, Alice Lucchetti, Robert Luther, Rahil Makadia, Elena Mazzotta Epifani, Jay McMahon, Gianmario Merisio, Colby C. Merrill, Alex J. Meyer, Patrick Michel, Marco Micheli, Alessandra Migliorini, Kate Minker, Dario Modenini, Fernando Moreno, Naomi Murdoch, Brian Murphy, Shantanu P. Naidu, Hari Nair, Ryota Nakano, Cyrielle Opitom, Jens Ormö, J. Michael Owen, Maurizio Pajola, Eric E. Palmer, Pasquale Palumbo, Paolo Panicucci, Laura M. Parro, Jason M. Pearl, Antti Penttilä, Davide Perna, Elisabeta Petrescu, Petr Pravec, Sabina D. Raducan, K. T. Ramesh, Ryan Ridden-Harper, Juan L. Rizos, Alessandro Rossi, Nathan X. Roth, Agata Rożek, Benjamin Rozitis, Eileen V. Ryan, William H. Ryan, Paul Sánchez, Toni Santana-Ros, Daniel J. Scheeres, Peter Scheirich, Cem Berk Senel, Colin Snodgrass, Stefania Soldini, Damya Souami, Thomas S. Statler, Rachel Street, Timothy J. Stubbs, Jessica M. Sunshine, Nicole J. Tan, Gonzalo Tancredi, Calley L. Tinsman, Paolo Tortora, Filippo Tusberti, James D. Walker, C. Dany Waller, Kai Wünnemann, Marco Zannoni, Yun Zhang

Publikováno v: The Planetary Science Journal, Vol 5, Iss 2, p 49 (2024)

NASA's Double Asteroid Redirection Test (DART) mission was the first to demonstrate asteroid deflection, and the mission's Level 1 requirements guided its planetary defense investigations. Here, we summarize DART's achievement of those requirements.

Externí odkaz: https://doaj.org/article/0a519bcd35754cc49681152142d32c4f

Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site

Autor: Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis

Externí odkaz: https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e

VLT/MUSE Characterization of Dimorphos Ejecta from the DART Impact

Autor: Brian P. Murphy, Cyrielle Opitom, Colin Snodgrass, Matthew M. Knight, Jian-Yang Li, Nancy L. Chabot, Andrew S. Rivkin, Simon F. Green, Paloma Guetzoyan, Daniel Gardener, Julia de León

Publikováno v: The Planetary Science Journal, Vol 4, Iss 12, p 238 (2023)

We have observed the Didymos-Dimorphos binary system with the MUSE integral field unit spectrograph mounted at the Very Large Telescope before and after DART impact and captured the ensuing ejecta cone, debris cloud, and tails at subarcsecond resolut

Externí odkaz: https://doaj.org/article/faa94491095a47989c0ff2369b8c99f0

Ischemic Stroke Injury Is Reduced in Mice Lacking a Functional NADPH Oxidase

Autor: Joanne Mathias, G. Roger Thomas, Simon P. Green, John T. Curnutte, Walter C. Darbonne, Julie Rae, Claire E. Walder, Mary C. Dinauer

Publikováno v: Stroke. 28:2252-2258

Background and Purpose Free radicals account for a significant proportion of the brain damage that occurs during ischemic stroke. Using mutant mice (X-CGD) with a dysfunctional phagocytic NADPH oxidase, we investigated the role of this superoxide-gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a946406d5114b6161cbca5d9f892f2
https://doi.org/10.1161/01.str.28.11.2252