Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Simon P Mackay"'
Autor:
Qosay Al-Balas, Nahoum G Anthony, Bilal Al-Jaidi, Amani Alnimr, Grainne Abbott, Alistair K Brown, Rebecca C Taylor, Gurdyal S Besra, Timothy D McHugh, Stephen H Gillespie, Blair F Johnston, Simon P Mackay, Geoffrey D Coxon
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5617 (2009)
BACKGROUND:Tuberculosis (TB) is a disease which kills two million people every year and infects approximately over one-third of the world's population. The difficulty in managing tuberculosis is the prolonged treatment duration, the emergence of drug
Externí odkaz:
https://doaj.org/article/413cd2c2511c4f40966985336191077d
Autor:
Christopher Riley, Usama Ammar, Aisha Alsfouk, Nahoum G. Anthony, Jessica Baiget, Giacomo Berretta, David Breen, Judith Huggan, Christopher Lawson, Kathryn McIntosh, Robin Plevin, Colin J. Suckling, Louise C. Young, Andrew Paul, Simon P. Mackay
Publikováno v:
Molecules, Vol 29, Iss 15, p 3515 (2024)
The inhibitory-kappaB kinases (IKKs) IKKα and IKKβ play central roles in regulating the non-canonical and canonical NF-κB signalling pathways. Whilst the proteins that transduce the signals of each pathway have been extensively characterised, the
Externí odkaz:
https://doaj.org/article/e3e2e03e3b834ed6981a0d5113267e5c
Autor:
Dimitrios A. Skoufias, Frank Kozielski, Simon P. Mackay, Shozeb Haider, Fangzhu Lin, Sandeep K. Talapatra, Rose-Laure Indorato
Time lapse imaging of untreated U2OS cells followed for 16h. Cells divide normally.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc866198baf92c0081139b302a3f115e
https://doi.org/10.1158/1535-7163.22509868
https://doi.org/10.1158/1535-7163.22509868
Autor:
Dimitrios A. Skoufias, Frank Kozielski, Simon P. Mackay, Shozeb Haider, Fangzhu Lin, Sandeep K. Talapatra, Rose-Laure Indorato
Molecular dynamics simulations of the Eg5(D130A)-Arry-520 complex.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e816c146c2d5519c7ac1701cb4cab3f
https://doi.org/10.1158/1535-7163.22509823
https://doi.org/10.1158/1535-7163.22509823
Autor:
Dimitrios A. Skoufias, Frank Kozielski, Simon P. Mackay, Shozeb Haider, Fangzhu Lin, Sandeep K. Talapatra, Rose-Laure Indorato
Arry-520 is an advanced drug candidate from the Eg5 inhibitor class undergoing clinical evaluation in patients with relapsed or refractory multiple myeloma. Here, we show by structural analysis that Arry-520 binds stoichiometrically to the motor doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8658ffd7e7127ff5b22cc8e9e92334dd
https://doi.org/10.1158/1535-7163.c.6539407.v1
https://doi.org/10.1158/1535-7163.c.6539407.v1
Autor:
Dimitrios A. Skoufias, Frank Kozielski, Simon P. Mackay, Shozeb Haider, Fangzhu Lin, Sandeep K. Talapatra, Rose-Laure Indorato
SV1-SV6: Time lapse imaging of untreated, Arry-520 and ispinesib treated naive U2OS cells, Eg5(D130) and Eg5(L214) expressing U2OS cells followed for 16h. SV7-SV12: Molecular dynamics simulations of either Eg5(WT), or Eg5(D130) or Eg5(L214) motor dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1855f5c63102b4238bd43f7be5c78df1
https://doi.org/10.1158/1535-7163.22509877
https://doi.org/10.1158/1535-7163.22509877
Autor:
Dimitrios A. Skoufias, Frank Kozielski, Simon P. Mackay, Shozeb Haider, Fangzhu Lin, Sandeep K. Talapatra, Rose-Laure Indorato
Table S1: Crystallographic table of data corresponding to the Eg5-Arry-520 complexes. Figure S1: Interactions of the inhibitor and conformational changes upon inhibitor binding. Figure S2: Surface representation of the allosteric inhibitor-binding po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1039447504df500c420ed42e4c047371
https://doi.org/10.1158/1535-7163.22509871.v1
https://doi.org/10.1158/1535-7163.22509871.v1
Autor:
Sabin Llona-Minguez, Simon P. Mackay
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1333-1338 (2014)
A convergent and stereoselective synthesis of chiral cyclopentyl- and cyclohexylamine derivatives of nucleoside Q precursor (PreQ0) has been accomplished. This synthetic route allows for an efficient preparation of 4-substituted analogues with intere
Externí odkaz:
https://doaj.org/article/f6a5198eb26f4f25862d9823e031a2fd
Autor:
Marco Haselager, Rachel Thijssen, Arnon P. Kater, Christopher West, Roel J. W. van Kampen, Elaine Willmore, Simon P. Mackay, Eric Eldering, Louise C. Young
Publikováno v:
Cell Death and Differentiation
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
Cell death and differentiation, 28(5), 1658-1668. Nature Publishing Group
In chronic lymphocytic leukemia (CLL), the lymph node (LN) microenvironment delivers critical survival signals by inducing the expression of anti-apoptotic Bcl-2 members Bcl-XL, Bfl-1, and Mcl-1, resulting in apoptosis blockade. We determined previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd804475140f3409a2804c3a88a8de7
http://europepmc.org/articles/PMC8167103
http://europepmc.org/articles/PMC8167103
Autor:
Thomas A. Burley, Emma Kennedy, Georgia Broad, Melanie Boyd, David Li, Timothy Woo, Christopher West, Eleni E. Ladikou, Iona Ashworth, Christopher Fegan, Rosalynd Johnston, Simon Mitchell, Simon P. Mackay, Andrea G. S. Pepper, Chris Pepper
Publikováno v:
Cancers; Volume 14; Issue 6; Pages: 1489
In this study, we evaluated an NF-κB inducing kinase (NIK) inhibitor, CW15337, in primary chronic lymphocytic leukemia (CLL) cells, CLL and multiple myeloma (MM) cell lines and normal B- and T-lymphocytes. Basal NF-κB subunit activity was character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6226df78d8c7a92096c67c5e3c187033
https://strathprints.strath.ac.uk/80165/1/Burley_etal_Cancers_2022_Targeting_the_non_canonical_NF_B_pathway_in_chronic_lymphocytic_leukemia.pdf
https://strathprints.strath.ac.uk/80165/1/Burley_etal_Cancers_2022_Targeting_the_non_canonical_NF_B_pathway_in_chronic_lymphocytic_leukemia.pdf